Acetaminophen is generally well tolerated and usually causes few if any, side effects. However, some mild adverse reactions may occur. Talk to your health care provider if these symptoms persist or become severe.
Common side effects reported from acetaminophen use include:
- Nausea
- Upset stomach
- Vomiting
- Loss of appetite
- Headache
- Dizziness or lightheadedness
- Sweating
Serious side effects include:
- Skin rash
- Swelling (mainly in the face, hands, ankles, legs, or feet)
- Hives
- Red, blistering, or peeling skin
- Insomnia
- Fatigue
- Difficulty breathing or swallowing
This is not a complete list of adverse reactions caused by acetaminophen. If you notice any symptoms of a severe adverse reaction, seek medical attention immediately. These are signs of a potentially life-threatening response to this medication and require urgent treatment from a health care provider.
Acetaminophen is widely available over the counter. If you have a history of adverse reactions to medication, are taking any medication or supplements, or are managing a medical condition, talk to a health care provider before taking acetaminophen. Specifically, tell your provider if you are taking anticoagulants, medication for seizures, medicines for mental health problems, or any other fever reducer or pain reliever. In addition, talk to a health care provider if you are pregnant, plan to become pregnant, or are breastfeeding before taking acetaminophen.
People who drink more than three alcoholic drinks a day should not use acetaminophen. Acetaminophen can interact with alcohol in the body, causing potentially serious side effects. If you regularly consume alcohol, talk to a health care provider before you take acetaminophen.