If you are interested in taking letrozole, the first step is to schedule an appointment with a Sesame provider. Browse the website and choose a provider. Some providers are available for same-day appointments.

During the appointment, your provider will discuss your health history, current medications, and current health concerns. Together, you will develop a treatment plan to determine if letrozole is a good choice for you.

Letrozole can be used to treat infertility. It can induce ovulation in women with PCOS or unexplained infertility.

Letrozole is also prescribed to treat hormone receptor–positive breast cancer. It may be prescribed after surgery to prevent the cancer from coming back. It can also be used after 5 years of tamoxifen therapy or to shrink an advanced tumor.

The price of letrozole can vary by pharmacy, location, whether you are purchasing a brand-name or generic version, and the quantity. Generic medications are cheaper than the brand-name versions. It is also sometimes cheaper to purchase a 3-month supply of medication. This may cost more initially, but it will be cheaper over the long term.

It is important to shop around, as pharmacies may offer different prices. The best price may even be at an online pharmacy.

No, you cannot buy letrozole over the counter. It is available by prescription only from a licensed provider.

Need a letrozole refill or prescription? A Sesame provider can provide you with a prescription after an appointment. Simply schedule a same-day appointment online and get started on your treatment.

All prescriptions are at the discretion of the provider.

When used for infertility, letrozole should cause ovulation about 5–10 days after the last pill. To know if you are ovulating, you can use ovulation predictor kits as well as basal body temperature monitoring.

Ovulation predictor kits are used to test the level of luteinizing hormone (LH) in the urine. LH levels surge about 24–36 hours before ovulation. These tests should be used starting around day 10 of your monthly cycle and should be used around the same time daily.

Basal body temperature monitoring uses a basal thermometer to test your daily temperature as soon as you wake up. You should take your temperature before getting out of bed, talking, or drinking water. It is best if the timing is consistent and you have at least 3 hours of uninterrupted sleep. Ovulation causes a slight increase in your basal body temperature. The 2–3 days before the temperature rise are when you are the most fertile.

Another sign of ovulation is a change in cervical mucus. Just before ovulation, mucus secretions increase and become clearer, wet, and slippery. After ovulation occurs, secretions may lessen and become thicker and cloudier.

A study that compared letrozole use to clomiphene use in women with PCOS showed that letrozole had better results. While both groups had comparable ovulation rates, those who took letrozole were more likely to get pregnant and give birth.

Those who took clomiphene had more hot flashes, while those in the letrozole group experienced more fatigue and dizziness.