Medically reviewed by Jessica Swirble, PharmD
Last updated on 4/18/2024

Drug Information | Side Effects | Use & Dosage | Request a Prescription

The use of bupropion can lead to various side effects in some individuals.

Common mild side effects of bupropion use include:

• Nausea
  
• Dry mouth
  
• Sore throat
  
• Headache
  
• Constipation
  
• Insomnia or drowsiness
  
• Increased sweating
  
• Increased urination
  
• Anxiety or excitement
  
• Tremors (uncontrollable shaking)
  
• Changes in appetite or weight
  
• Dizziness
  
• Blurred vision
  
• Ringing in the ears
  
• Changes in taste
  
• Increased heart rate
  
  

More severe side effects of bupropion use can include:

• Seizures (especially at higher doses)
  
• Suicidal thoughts or behavior (especially in young adults)
  
• Agitation or restlessness
  
• Manic episodes (abnormally high energy, racing thoughts, reckless behavior)
  
• Hallucinations
  
• Irregular heartbeat
  
• Severe allergic reactions (rash, itching/swelling, severe dizziness, trouble breathing)
  
  

If you experience any severe side effects while taking bupropion, seek immediate medical attention.

Inform your healthcare provider about any existing medical conditions, allergies, or other medications you are taking before starting treatment with bupropion. This includes prescription drugs, over-the-counter medications, and dietary supplements, as they may interact with bupropion.

Tell your provider if you are taking these medications or supplements:

• MAO inhibitors (e.g., selegiline, phenelzine)
  
• Other antidepressants (e.g., SSRIs, SNRIs, tricyclic antidepressants)
  
• Antipsychotics
  
• Anti-seizure medications
  
• Blood thinners (e.g., warfarin)
  
• Stimulants
  
• Herbal supplements (e.g., St. John's wort)
  
  

Mention medical conditions such as:

• History of seizures or epilepsy
  
• Bipolar disorder or mania
  
• Eating disorders
  
• Liver or kidney disease
  
• High blood pressure
  
• Heart disease
  
• Diabetes
  
• Glaucoma
  
• Alcohol or substance use disorder
  
  

If you are pregnant, planning to become pregnant, or breastfeeding, consult your healthcare provider before using bupropion to assess potential risks and benefits.

Take bupropion exactly as prescribed by your healthcare provider. Do not increase or decrease the dosage without consulting them.

It may take several weeks for bupropion to take full effect. Continue taking the medication even if you do not immediately feel better.

Avoid alcohol while taking bupropion, as it may worsen certain side effects and increase the risk of seizures.

Do not suddenly stop taking bupropion without your healthcare provider's guidance, as it may cause withdrawal symptoms.

In case of a bupropion overdose, seek immediate medical attention. Symptoms may include seizures, hallucinations, rapid heart rate, fainting, and loss of consciousness. If you suspect an overdose, contact the poison control helpline at 1-800-222-1222 or call emergency services.