Prednisone can cause side effects, especially when taken long-term. Common side effects include increased appetite and prednisone-related weight gain due to fluid retention, irritability, restlessness, or feeling unusually energetic, as well as headache, nausea, acne, heartburn, increased sweating, and trouble sleeping. Over time, corticosteroids can affect bone health.
While taking prednisone, it is advised to avoid live vaccines and excessive alcohol. Prednisone can interact with certain medications and supplements, including St. John’s wort, birth control pills, blood thinners, diuretics, and other anti-inflammatory drugs.
Contact a healthcare provider right away if you experience serious side effects, including signs of infection, vision changes or eye pain, severe mood changes or depression, uncontrollable shaking, difficulty breathing or swallowing, or an irregular heartbeat.
Prednisone may not be safe for everyone. People with uncontrolled infections, certain fungal infections, or a known allergy to corticosteroids should not take it. Those with chronic conditions such as diabetes, high blood pressure, or heart disease should consult a provider to ensure the medication is safe and monitored appropriately.
If you have questions about side effects, precautions, or whether prednisone is right for you, connect with a licensed provider through Sesame. Be sure to tell your provider if you are pregnant, breastfeeding, or planning to become pregnant before starting treatment.