Prednisone is generally considered a safe medication for short-term use and most side effects tend to be rare and mild. Common side effects include loss of appetite, weight gain, confusion, excitement, restlessness, headache, nausea, acne, heartburn, increased sweating, and trouble sleeping. If these are mild, they may go away within a few days as your body gets used to the treatment. If they do not go away or worsen, consult your doctor.
Some side effects may be serious. Seek immediate medical attention if you experience severe allergic reactions, eye pain or vision problems, any signs of infections, seizures, depression, uncontrollable shaking, difficulty breathing or swallowing, or an irregular heartbeat.
Be sure to make your doctor aware of any known allergies as well as all prescription and non-prescription medications, vitamins, and supplements that you may be taking.
This is not a complete list of possible side effects. For more information on adverse effects you may experience while taking prednisone, visit the National Institutes of Health’s DailyMed webpage.