The time it takes to feel the full effects of sertraline (Zoloft) can vary. Some people notice improvements after taking a depression and/or anxiety medication within a few weeks, while it may take a few months of consistent treatment for others.

It’s important to take sertraline exactly as prescribed, even if you don’t feel better right away. If you have concerns about your progress or side effects, talk with your healthcare provider before making any changes.

Avoid alcohol while taking sertraline (Zoloft), as it can worsen side effects like drowsiness, dizziness, or impaired judgment.

Be cautious with other medications that affect serotonin levels. That includes other SSRIs or SNRIs (e.g., fluoxetine, venlafaxine), tricyclic antidepressants, MAO inhibitors (MAOIs), certain migraine medications, some over-the-counter dietary supplements (e.g., St. John's wort), and dextromethorphan, commonly found in cough medicines.

Always check with your provider before starting any new medications or supplements while on sertraline.

Sertraline (Zoloft) may not be safe for everyone. Avoid sertraline if you have had an allergic reaction to the drug or any of its inactive ingredients in the past. It is generally not recommended for people taking other medications that increase serotonin levels, as it can increase their risk of serotonin syndrome.

Pregnant or breastfeeding individuals should only take sertraline if clearly needed and under close supervision. People with certain heart conditions, bleeding disorders, liver or kidney disease, or a history of glaucoma, seizures, diabetes, or bipolar disorder should discuss potential risks with their provider before starting sertraline.

If you forget to take a dose of sertraline (Zoloft), take it as soon as you remember. If it’s nearly time for your next scheduled dose, skip the missed one and continue with your normal routine. Do not take two doses at the same time.

Missing a dose once in a while is generally not dangerous, but regularly skipping doses can make the medication less effective. It may also cause withdrawal-like symptoms that include irritability, dizziness, or symptoms that look like the flu. Always follow your provider’s directions and reach out to them if you have any questions or concerns.

Taking a higher dose of sertraline (Zoloft) than prescribed can increase the risk of side effects. Symptoms may include stomach upset, restlessness, shakiness, disorientation, or changes in heart rate.

In more serious situations, excessive amounts of sertraline can trigger seizures, heart rhythm disturbances, or serotonin syndrome. If you believe you have taken too much sertraline or notice serious symptoms, seek emergency medical care right away.

Sertraline (Zoloft) is currently only available via prescription. This means the use of this drug must be authorized by a licensed healthcare provider.

If you're looking for a prescription for sertraline or Zoloft online, book a telehealth appointment to talk to a provider who can write a new prescription or refill an existing prescription. Depending on the medication, you can arrange for same-day pickup from a pharmacist near you.

Note that all prescriptions are at the discretion of your healthcare provider. Providers on Sesame cannot prescribe controlled substances.

You can request a refill of your sertraline (Zoloft) prescription online through a Sesame provider. Online prescription refill appointments on Sesame are available 24/7 in all 50 states. You can book these visits whenever you need to talk to a provider about a prescription refill as part of Mental Health Rx, Sesame’s online program for mental health medications.

Providers on Sesame can typically assist with refilling 1-2 existing prescriptions during a prescription refill appointment. If you require additional medication, your provider may require a longer or additional visit so that there is time to adequately review and assess your medication needs.

There are several other prescription options that are FDA-approved to support anxiety and/or depression treatment besides sertraline. These include:

• Escitalopram (Generic for Lexapro)
  
• Fluoxetine (Generic for Prozac)
  
• Buspirone (Generic for Buspar)
  
• Venlafaxine ER (Generic for Effexor XR)
  
• Duloxetine DR (Generic for Cymbalta)
  
• Citalopram (Generic for Celexa)
  
• Hydroxyzine Hydrochloride (Generic for Atarax)
  
• Paroxetine (Generic for Paxil)
  
• Doxepin (Generic for Silenor)
  

Each medication works differently, and the right choice depends on your symptoms, medical history, and response to treatment. Always talk with your healthcare provider before starting or switching medications. They can also help you compare treatments, for example, Zoloft vs. Prozac.