Buy sertraline (generic Zoloft) prescriptions and medications online for depression, anxiety, and more.

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Product Overview

Sertraline (generic Zoloft)

  • What is Sertraline?
    Sertraline (Generic Zoloft) is a prescription drug used to treat a range of mental health conditions, including depression, obsessive-compulsive disorder, panic attacks, post-traumatic stress disorder, and anxiety disorder.

    Talk to your doctor about whether Sertraline is right for you.

  • What are common side effects of Sertraline?
    While adverse reactions to sertraline are rare, some patients who take the drug may experience mild side effects, including nausea, diarrhea, dry mouth, insomnia, dizziness, fatigue, and drowsiness.

    Rare, more serious adverse events have been known to occur, including seizures, abnormal bleeding or bruising, hallucinations, fever, confusion, fast heartbeat, shivering, severe muscle stiffness or twitching, loss of coordination, vomiting, rash, hives, or trouble breathing. Call your doctor immediately if you are experiencing any of these symptoms.

    Though rare, sertraline and other antidepressants may sometimes increase suicidal thoughts or actions in patients under the age of 24. You should begin taking sertraline under the close supervision of a healthcare provider. If you are feeling suicidal, call the National Suicide Prevention Lifeline at 800-273-8255 or dial 911.

    This is not a complete list of side effects. For more information on adverse effects you may experience while taking sertraline, please visit the National Institutes of Health’s DailyMed webpage.

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Medically Reviewed By Dr. Allison Edwards, MD

Frequently asked questions about Sertraline

What is sertraline Hcl?

Sertraline is a prescription antidepressant medication.

Sertraline is used to treat depression because it increases the amount of serotonin in the brain. Serotonin is a chemical that the body produces to transmit messages between nerves. It’s thought to play an important role in regulating certain emotional behavior, like anxiety and aggression. Having the proper amount of serotonin available in your brain stabilizes your mood and makes you feel happy.

The CDC estimates that almost 19% of Americans exhibited some symptoms of depression in 2019. Often caused by chemical imbalances in the brain, depression is characterized by a persistently depressed mood and a loss of interest in your passions and hobbies.

What is sertraline Hcl used to treat?

The FDA has approved sertraline to treat a wide range of mental health disorders including major depressive disorder (MDD), obsessive-compulsive disorder (OCD), panic disorder, post-traumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD), and social anxiety disorder (SAD), and OCD in children and adolescents ages 6-17. Sertraline is also sometimes used to treat headaches and sexual problems.

How does sertraline Hcl work?

Sertraline works by blocking the reabsorption of serotonin in our brain cells. Serotonin is a hormone that is naturally produced and released by the brain. It is associated with feelings of happiness and helps stabilize your mood and outlook. Sometimes, your brain reabsorbs the serotonin too quickly after producing it, depriving the brain of the chemicals that, simply put, make it feel good. Sertraline works by blocking this overzealous reabsorption, which doctors call “reuptake,” to increase the amount of serotonin in circulation in your brain. It is believed that low levels of serotonin may cause depression and anxiety.

What are the most common side effects of sertraline Hcl?

The most common side effects while using sertraline include nausea, diarrhea, dry mouth, insomnia, dizziness, fatigue, and drowsiness. Tell your doctor if you have any side effects that bother you or that do not go away. While rare, some side effects can be serious. Call your doctor right away if you experience seizures, abnormal bleeding or bruising, hallucinations, fever, confusion, fast heartbeat, shivering, severe muscle stiffness or twitching, loss of coordination, vomiting, rash, hives, or trouble breathing.

This is not a complete list of possible side effects of sertraline. For more information, visit the National Institutes of Health’s DailyMed webpage.

WARNING: In short-term studies of major depressive disorder (MDD) and other psychiatric disorders, antidepressants showed an increased risk of suicidal thinking and behavior in children, adolescents, and young adults compared to placebo. Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. Patients of all ages who are started on antidepressant therapy should be monitored appropriately and observed closely for clinical worsening, suicidality, or unusual changes in behavior.

If you are experiencing suicidal thoughts, please immediately call the National Suicide Prevention Lifeline at 800-273-8255 or 911.

How long does it take for Sertraline Hcl to work?

You may see improvements in your sleep, energy, and appetite within the first 1-2 weeks of taking sertraline. However, it usually takes 4-6 weeks to feel the full effects of Sertraline.

Depression, anxiety, or obsessive-compulsive disorder can be recurrent conditions. It is important to take sertraline for as long as your doctor prescribes it. If you stop taking sertraline too soon, your symptoms may return. Do not stop taking sertraline without talking to your doctor.

What is the typical starting dose of Sertraline Hcl?

The usual starting dose for sertraline is 25 mg or 50 mg depending on the condition being treated. If the desired result is not achieved at this dosage, the doctor may increase the dosage in one to two-week intervals until an adequate response is achieved.

Sertraline is available in the United States in tablet, capsule, and liquid form and is generally taken once a day, either in the morning or evening. It can be taken with or without food. Use only as directed by your doctor or pharmacist.

Can I get Sertraline Hcl over-the-counter?

Sertraline Hcl is currently only available via prescription. This means the use of this drug must be authorized by a licensed health care provider.

Looking for a prescription? Good news! Providers on Sesame can write a prescription – or refill an existing one – during a virtual or in-person visit. Depending on the medication, you can arrange for same-day pickup at a pharmacy near you or order the medication to be delivered to your door for just $5. Book an online consultation with a real, licensed provider on Sesame today to determine whether or not sertraline is right for you.

Note that all prescriptions are at the discretion of your health care provider. Providers on Sesame cannot prescribe controlled substances.

Can I get Sertraline HCL online?

Yes! Sesame offers a fully integrated prescription service, which means you can get the medication you need delivered right to your door, starting at just $5 a month.

Talk to a provider on Sesame and get your online doctor prescription or refill ordered right away for fast and convenient pickup from a pharmacy of your choice.

Note that all prescriptions are at the discretion of your clinician.

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