Get a ondansetron (generic Zofran) prescription online for nausea and vomiting

Prevent nausea and vomiting with FDA-approved ondansetron (generic Zofran). Talk to a doctor about an online prescription and pick up at your local pharmacy today.

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Product Overview

Ondansetron (generic Zofran)

What is ondansetron?
Ondansetron (generic Zofran) is a prescription medication typically given to patients undergoing chemotherapy, radiation therapy, or surgery to prevent nausea and vomiting.
What are common side effects of ondansetron?
While adverse reactions to ondansetron are uncommon, some patients who take the drug may experience mild side effects, including headache, constipation, weakness, tiredness, chills, and drowsiness.

Rare, more serious adverse events have also been known to occur, including irregular heartbeats. If you are concerned that ondansetron may be causing you to experience any number of adverse side effects, please contact your doctor or clinician.

This is not a complete list of side effects. If you are concerned about additional side effects, please contact your provider directly.

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Medically Reviewed By Dr. Allison Edwards, MD

Frequently asked questions about ondansetron

What is ondansetron?

Ondansetron (generic Zofran) is a prescription medication typically given to patients undergoing chemotherapy, radiation therapy, or surgery to prevent nausea and vomiting.

What is ondansetron used to treat?

Ondansetron is used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, and surgery. It is typically given before the therapy or operation to prevent the feelings of nausea and vomiting from occurring. It is estimated that 70-80% of people undergoing chemotherapy or radiation therapy will experience nausea or vomiting. Nausea and vomiting are common side effects of anesthesia used in surgeries. When taken before surgery, ondansetron can help reduce the risk of this side effect.

How does ondansetron work?

Ondansetron is in the class of medications called serotonin 5-HT₃ receptor antagonists. It works on the body’s natural chemicals that are responsible for the nausea.

Chemotherapy and radiation therapy cause the release of serotonin 5-HT₃, a neurotransmitter in the central nervous system that triggers the nerves that bring about the vomiting reflex. Serotonin 5-HT₃ receptor antagonist medication- such as Ondansetron- blocks serotonin from reaching the nerves. This prevents feelings of nausea or the need to vomit.

What are common side effects of ondansetron?

While adverse reactions to ondansetron are uncommon, some patients who take the drug may experience mild side effects, including:

headache
constipation
weakness
tiredness
chills
drowsiness

If any of the side effects above are severe or do not go away, you should contact your doctor. Rare, more serious side effects may occur. If you experience any symptoms listed below, contact your doctor right away.

blurred vision or vision loss
Rash or hives
swelling of the eyes, face, lips, tongue, throat, hands, feet, ankles, or lower legs
difficulty breathing or swallowing
chest pain
seizures Because ondansetron can cause drowsiness and dizziness, especially when you first start taking it, it is advised to avoid driving or operating machinery until you know how the drug may affect you. This is not a complete list of ondansetron’s side effects. For more information on advice effects associated with ondansetron, please visit the National Institutes of Health’s DailyMed webpage.

How long does it take for ondansetron to work?

Ondansetron typically takes 30-60 minutes to work.

What is a typical starting dose of ondansetron?

Ondansetron is prescribed as a film-coated tablet.

Adults with cancer are typically given 24 mg 30 minutes before the start of chemotherapy. Additional doses are sometimes given after the chemotherapy if needed.

For more moderate post-chemotherapy nausea and vomiting, 8 mg is given 30 minutes before starting cancer treatment. The 8 mg dose is taken again 8 hours after the first dose. Then, the dose is 8 mg every 12 hours for 1 to 2 days.

Patients undergoing radiotherapy are typically given 8 mg 1-2 hours before radiotherapy.

Patients undergoing surgery are typically given 16 mg 1 hour before receiving anesthesia.

Can I get ondansetron over-the-counter?

Ondansetron is currently only available via prescription. This means the use of this drug must be authorized by a licensed health care provider.

Providers on Sesame can write a prescription – or refill an existing one – during a virtual or in-person visit. Depending on the medication, you can arrange for same-day pickup at a pharmacy near you. Book an online consultation with a real, licensed provider on Sesame today to determine whether or not ondansetron is right for you.

Note that all prescriptions are at the discretion of your health care provider. Providers on Sesame cannot prescribe controlled substances.

Can I get ondansetron online?

Yes! Talk to a provider on Sesame and get your online doctor prescription or refill ordered right away for fast and convenient pickup from a pharmacy of your choice.

Note that all prescriptions are at the discretion of your clinician.