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Celecoxib

Common Brand Names: Celebrex

Drug Information

Medically reviewed by Jessica Swirble, PharmD
Last updated on April 18, 2025

Drug Information | Side Effects | Use & Dosage | Request an Online Prescription

Quick facts:

  • Brand Name: Celebrex
  • Generic Name: Celecoxib
  • Uses: Treatment for pain, inflammation, and stiffness
  • Drug Class: COX-2 inhibitor nonsteroidal anti-inflammatory drug (NSAID)
  • Availability: Prescription only
  • Generic Status: Yes
  • Controlled Substance: No

What is celecoxib?

Celecoxib is a prescription medication used to treat pain, inflammation, and stiffness caused by various types of arthritis. It’s also used to treat these symptoms in children with juvenile rheumatoid arthritis.

In addition to its use in treating symptoms caused by different forms of arthritis, celecoxib may be prescribed to reduce pain and discomfort caused by menstruation, surgery, or injury.

What is celecoxib used to treat?

Celecoxib is prescribed to reduce pain, inflammation, and stiffness caused by various types of arthritis.

This includes:

  • Rheumatoid arthritis: An autoimmune condition in which the nervous system attacks joint tissue, causing inflammation and pain in the joints
  • Osteoarthritis: A degenerative disease in which joint tissue breaks down over time, leading to inflammation, stiffness, and pain
  • Juvenile rheumatoid arthritis: A type of rheumatoid arthritis that occurs in children
  • Ankylosing spondylitis: Arthritis that affects the spine

Celecoxib is also prescribed to reduce pain and discomfort caused by:

  • Menstruation
  • Surgery
  • Dental procedures
  • Musculoskeletal injury

How does celecoxib work?

Celecoxib belongs to a class of drugs known as nonsteroidal anti-inflammatory drugs (NSAIDs). More specifically, it is a COX-2 inhibitor.

These drugs work by blocking the COX-2 enzyme, which promotes the production of prostaglandins—chemicals responsible for pain and inflammation. By inhibiting these enzymes, NSAIDs lower the levels of prostaglandins, subsequently alleviating pain and decreasing inflammation.

How do I take celecoxib?

Celecoxib is available as an oral capsule.

The dosage and frequency of use depend on the condition being treated, its severity, and how you respond to the medication.

Follow your healthcare provider's instructions regarding dosage and schedule. Do not exceed the prescribed dose or frequency of use without consulting your provider.

How long until I feel better?

Celecoxib is used to manage pain, inflammation, and stiffness associated with arthritis, menstrual pain, and other conditions. The effects can be noticeable within a few hours, but it may take several days to feel optimal symptom relief.

Continue using celecoxib as prescribed, even if you start feeling better. Regular use according to your prescription is crucial for the management of symptoms.

Are there any other uses for celecoxib?

While celecoxib is primarily used for treating pain and inflammation, healthcare providers may prescribe it off-label for other conditions.

Discuss any alternative uses of celecoxib with your healthcare provider.

Dosage forms of celecoxib

Celecoxib is available in the following dosage forms:

  • Oral capsules

Celecoxib is a prescription medication. You must have a valid prescription from a licensed healthcare provider to obtain it.

Side Effects and Precautions for Celecoxib


Drug Information | Side Effects | Use & Dosage | Request an Online Prescription

What are the side effects of celecoxib?

The use of celecoxib can lead to various side effects in some individuals.

Common mild side effects of celecoxib use include:

  • Gas
  • Bloating
  • Diarrhea
  • Constipation
  • Nausea
  • Vomiting
  • Dizziness
  • Abdominal pain
  • Altered taste
  • Cold symptoms such as a runny nose or sore throat

More severe side effects of celecoxib use can include:

  • Weight gain
  • Skin rash
  • Hives
  • Swelling in the hands, feet, or ankles
  • Nausea
  • Flu-like symptoms
  • Difficulty breathing or swallowing
  • Changes in heartbeat
  • Chest pain
  • High blood pressure
  • Pale skin
  • Yellowing of the skin or eyes
  • Vomiting
  • Blood in stool

If you experience any severe or concerning side effects while taking celecoxib, contact your healthcare provider right away.

What should I tell my healthcare provider before using celecoxib?

Inform your healthcare provider about any existing medical conditions, allergies, or other medications you are taking before starting treatment with celecoxib. This includes prescription drugs, over-the-counter medications, and dietary supplements, as they may interact with celecoxib.

Tell your provider if you are taking these medications or supplements:

  • ACE inhibitors
  • Angiotensin receptor blockers
  • Beta-blockers
  • Digoxin
  • Diuretics
  • Fluconazole
  • Lithium
  • Methotrexate
  • Blood thinners
  • Other NSAIDs
  • Aspirin or salicylates

You should also mention medical conditions such as:

  • Asthma
  • Nasal polyps
  • Stomach ulcers
  • Heart disease
  • High blood pressure
  • Bleeding disorders
  • Liver disease
  • Kidney disease
  • Alcohol or tobacco use

If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of using celecoxib with your healthcare provider.

Are there any other special instructions I should follow?

Take celecoxib exactly as prescribed by your healthcare provider. Do not exceed the recommended dose or duration of treatment.

Your provider may direct you to avoid alcohol and smoking while taking celecoxib, as they can increase your risk of stomach bleeding.

Complete the full course of treatment, even if you feel better, to ensure the medication's effectiveness in managing your condition.

What should I do in case of an overdose?

In case of a celecoxib overdose, seek medical attention immediately. Symptoms of overdose may include severe stomach pain, nausea, vomiting, drowsiness, or difficulty breathing. If you suspect an overdose, contact the poison control helpline at 1-800-222-1222 or call emergency services.

Proper Use & Dosage Information for Celecoxib


Drug Information | Side Effects | Use & Dosage | Request an Online Prescription

What is the typical starting dose for celecoxib?

Celecoxib is available in the following forms:

  • Oral capsules (50 mg; 100 mg; 200 mg; 400 mg)

The typical starting dose of celecoxib varies depending on the condition being treated, the severity of symptoms, and individual patient factors. It is crucial to follow your healthcare provider's instructions regarding dosage and administration.

For osteoarthritis:

  • Adults: Initial doses typically start at 200 mg once daily or 100 mg twice daily.

For rheumatoid arthritis:

  • Adults: Initial doses typically start at 100 mg to 200 mg twice daily.

For pain or menstrual pain:

  • Adults: Initial doses start at 400 mg, followed by an additional 200 mg if needed on the first day. Subsequently, 200 mg twice daily as needed.

The dosage may be adjusted based on the response and tolerance to the medication. Your healthcare provider will determine the most appropriate dose based on your medical history and your response to the medication.

Celecoxib should be taken as prescribed by your healthcare provider. Do not exceed the recommended dose or duration of treatment without consulting your provider.

If you have any questions about your dosage or need adjustments, contact your healthcare provider for guidance. If you want to talk to a provider right away, consider scheduling an online doctor appointment through a telehealth platform like Sesame.

What should I do if I miss a dose of celecoxib?

If you miss a dose of celecoxib, take it as soon as you remember unless it is close to the time for your next scheduled dose. In that case, skip the missed dose and continue your regular dosing schedule. Do not double the dose to make up for a missed one.

Take celecoxib around the same time every day to maintain a consistent amount of medication in your body.

What should I do if I'm feeling better while taking celecoxib?

Continue taking celecoxib as prescribed by your healthcare provider, even if you start feeling better. It's important to keep taking the medication as directed to manage your condition effectively.

Do not suddenly stop taking celecoxib; this can cause your symptoms to return.

If you have any concerns or questions about your medication, discuss them with your healthcare provider for medical advice and recommendations.

How should I store celecoxib?

Store celecoxib according to the instructions provided by your healthcare provider or pharmacist. Keep it at room temperature, away from light and moisture. Ensure the container is tightly closed and out of reach of children.

Do not use expired medication or medications that appear damaged or discolored. If you have any questions about storage, consult your healthcare provider or pharmacist for guidance.

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