Medically reviewed by Jessica Swirble, PharmD
Last updated on 4/18/2024

Drug Information | Side Effects | Use & Dosage | Request a Prescription

The use of clindamycin, whether in oral or topical form, can lead to various side effects in some individuals.

Common mild side effects of clindamycin use include:

• Nausea
  
• Vomiting
  
• Diarrhea
  
• Stomach pain
  
• Heartburn
  
• Loss of appetite
  
• Skin rash or itching (for topical use)
  
• Dry or peeling skin (for topical use)
  
• Throat irritation or soreness (for topical use)
  
  

More severe side effects of clindamycin use can include:

• Severe diarrhea
  
• Abdominal pain
  
• Allergic reactions, such as hives, itching, swelling of the face or throat, difficulty breathing (for both oral and topical use)
  
• Severe skin reactions, including blistering, peeling, or a severe rash (for both oral and topical use)
  
• Yellowing of the skin or eyes (jaundice)
  
• Dark urine
  
• Unusual tiredness
  
• Changes in bowel habits, such as bloody or watery stools
  
• Difficulty swallowing or breathing (for topical use if accidentally ingested)
  
• Tingling or numbness in the hands or feet
  
• Unusual vaginal discharge or itching (for topical use)
  
  

If you experience any severe side effects while using clindamycin, especially those that indicate an allergic reaction or severe skin reaction, seek medical attention immediately.

Before using clindamycin, it's important to inform your healthcare provider about any existing medical conditions, allergies, or medications you are currently taking. This includes prescription drugs, over-the-counter medications, and dietary supplements, as they may interact with clindamycin.

Tell your provider if you are taking the following medications or supplements:

• Any other antibiotics
  
• Drugs that impact intestinal health or digestion
  
• Nonsteroidal anti-inflammatory drugs (NSAIDs)
  
• Blood thinners (anticoagulants)
  
• Muscle relaxants
  
• Herbal supplements like St. John's wort or others
  
  

Mention any medical conditions you have, such as:

• Gastrointestinal disorders or history of intestinal issues (like Crohn’s disease or colitis)
  
• Allergic reactions to antibiotics or related medications
  
• Blood clotting disorders or history of bleeding complications
  
• Liver or kidney conditions
  
• Asthma
  
• Eczema
  
• Allergies
  
  

If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of using clindamycin with your healthcare provider.

For oral clindamycin:

• Taking clindamycin with food can help reduce the risk of GI distress (like an upset stomach). Talk to your provider about any foods you should avoid while taking clindamycin.
  
  

For topical clindamycin:

• Apply topical clindamycin according to the instructions provided by your healthcare provider or pharmacist. Use a thin layer on clean, dry skin.
  
• Avoid getting topical clindamycin into your eyes, mouth, or nose. If accidental contact occurs, rinse thoroughly with water.
  
  

In case of a clindamycin overdose, seek medical attention immediately. Symptoms of overdose may include severe diarrhea, vomiting, or abdominal pain. If you suspect an overdose, contact the poison control helpline at 1-800-222-1222 or call emergency services.