Medically reviewed by Jessica Swirble, PharmD
Last updated on 5/24/2024

Drug Information | Side Effects | Use & Dosage | Request a Prescription

The use of clonidine can lead to various side effects in some individuals.

Common mild side effects of clonidine use include:

• Dry mouth
  
• Dizziness/ lightheadedness
  
• Drowsiness
  
• Constipation
  
• Headache
  
• Nausea
  
• Fatigue
  
• Abdominal pain
  
  

More severe side effects of clonidine use can include:

• Skin rash
  
• Hives
  
• Swelling
  
• Difficulty breathing or swallowing
  
• Hoarseness
  
• Severe chest pain
  
• A very slow heart rate
  
• Withdrawal syndrome (high blood pressure)
  
  

If you experience any severe or concerning side effects while taking clonidine, contact your healthcare provider right away.

Inform your healthcare provider about any existing medical conditions, allergies, or other medications you are taking before starting treatment with clonidine. This includes prescription drugs, over-the-counter medications, and dietary supplements, as they may interact with clonidine.

Tell your provider if you are taking these medications or supplements:

• Other blood pressure medications
  
• Antidepressants
  
• Sedatives or medications for anxiety
  
• Sleeping pills
  
• Heart rhythm medications
  
• Opioid medications or treatments for opioid withdrawal
  
• Nonsteroidal anti-inflammatory drugs (NSAIDs)
  
• Anticoagulants or antiplatelet drugs
  
  

You should also mention medical conditions such as:

• History of heart disease or stroke
  
• Recent heart attacks
  
• Kidney disease
  
• Severe coronary artery disease
  
• Mental health conditions like depression
  
  

If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of using clonidine with your healthcare provider.

Take clonidine exactly as prescribed by your healthcare provider. Do not exceed the recommended dose or duration of treatment.

Clonidine can be taken with or without food, but taking it with food may help reduce stomach upset. It's important to complete the full course of treatment, even if you feel better, to ensure the medication's effectiveness in managing your condition.

In case of a clonidine overdose, seek medical attention immediately. Symptoms of overdose may include severe drowsiness, slow heart rate, severe dizziness, or fainting. If you suspect an overdose, contact the poison control helpline at 1-800-222-1222 or call emergency services.