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Fluoxetine

Common Brand Names: Prozac

Drug Information

Medically reviewed by Jessica Swirble, PharmD
Last updated on April 17, 2025

Drug Information | Side Effects | Use & Dosage | Request an Online Prescription

Quick Facts

  • Brand Name: Prozac
  • Generic Name: Fluoxetine
  • Uses: Treating depression, obsessive-compulsive disorder (OCD), bulimia nervosa, and panic disorder
  • Drug Class: Selective Serotonin Reuptake Inhibitor (SSRI)
  • Availability: Prescription only
  • Generic Status: Yes
  • Controlled Substance: No

What is fluoxetine?

Fluoxetine is a medication used to treat depression, certain eating disorders, obsessive-compulsive disorder, and panic disorder. It belongs to a class of drugs known as selective serotonin reuptake inhibitors (SSRIs), which increase serotonin levels in the brain.

What conditions does fluoxetine treat?

Fluoxetine is prescribed for mental health conditions like:

  • Major depressive disorder (depression)
  • Eating disorders (primarily bulimia nervosa)
  • Obsessive-compulsive disorder
  • Panic disorder and panic attacks

How does fluoxetine work?

Fluoxetine belongs to a class of drugs called selective serotonin reuptake inhibitors. These drugs work by blocking the reuptake of serotonin, a neurotransmitter that plays a crucial role in stabilizing mood. By blocking the reuptake of serotonin, these drugs increase levels of serotonin in the brain.

How do I take fluoxetine?

Fluoxetine is available in various forms:

  • Oral capsules: Available in immediate and delayed-release forms
  • Oral tablets
  • Oral solution (liquid)

The dosage and length of treatment depend on the condition being treated, its severity, and how you tolerate the medication.

Follow your healthcare provider's instructions regarding dosage and schedule. Do not exceed the prescribed dose or duration of treatment without consulting your provider.

How long until I feel better?

The effectiveness of fluoxetine and the time it takes to notice improvement can vary among individuals. In the treatment of depression, it may take several weeks to feel the full benefit of the medication.

Continue taking fluoxetine as prescribed even if you start feeling better. Do not abruptly stop the medication, as it may lead to a return of symptoms or withdrawal-like effects.

Are there any other uses for fluoxetine?

While fluoxetine is primarily used for treating depression, obsessive-compulsive disorder, bulimia nervosa, and panic disorder, healthcare providers may sometimes prescribe it off-label for other conditions related to mood or anxiety.

Discuss any alternative uses of fluoxetine with your healthcare provider.

Side Effects and Precautions for Fluoxetine


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What are the side effects of fluoxetine?

The use of fluoxetine can lead to various side effects in some individuals.

Common mild side effects of fluoxetine use include:

  • Insomnia
  • Nervousness/ restlessness
  • Headache
  • Difficulty concentrating
  • Nausea
  • Diarrhea
  • Dizziness
  • Heartburn
  • Uncontrollable shaking
  • Loss of appetite
  • Weight loss
  • Stuffy nose
  • Sexual dysfunction in men and women
  • Dry mouth

More severe side effects of fluoxetine use can include:

  • Severe skin reactions, such as rash or hives
  • Allergic reactions (like rash, itching, swelling of the face, tongue, or throat, trouble breathing)
  • Liver problems (symptoms may include yellowing of the skin or eyes, itching, right-sided upper belly pain)
  • Abnormal bleeding
  • Suicidal thoughts or behaviors, especially in young adults and adolescents
  • Serotonin syndrome (symptoms include high fever, agitation, confusion, trembling, sweating, rapid heartbeat)
  • Severe neurological disturbances (like seizures and manic episodes)
  • Changes in vision

If you experience any severe or concerning side effects while taking fluoxetine, contact your healthcare provider right away.

What should I tell my healthcare provider before using fluoxetine?

Tell your healthcare provider about any existing medical conditions, allergies, or other medications you are taking before starting treatment with pantoprazole. This includes prescription drugs, over-the-counter medications, and dietary supplements, as they may interact with fluoxetine.

Tell your provider if you are taking these medications or supplements:

  • MAOI medications
  • Benzodiazepines
  • Antibiotics
  • Antipsychotic medication
  • Anticonvulsant medications
  • NSAID medications
  • Antiplatelet medications
  • Heart rhythm medications

You should also mention medical conditions such as:

  • Liver disease
  • Diabetes
  • Glaucoma
  • Seizures or epilepsy
  • Prolonged QT interval
  • Heart problems
  • High blood pressure
  • Bipolar disorder
  • Electroconvulsive therapy
  • Osteoporosis

If you are pregnant, planning to become pregnant, or breastfeeding, consult your healthcare provider before using fluoxetine to assess potential risks and benefits.

Are there any other special instructions I should follow?

Take fluoxetine exactly as prescribed by your healthcare provider. Do not exceed the recommended dose or duration of treatment.

Fluoxetine can impair your thinking or behavior. It can also cause drowsiness (especially when taken with alcohol). Do not operate heavy machinery or vehicles until you know how fluoxetine affects you.

Take fluoxetine around the same time every day (preferably in the morning). Fluoxetine can be taken with or without food.

What should I do in case of an overdose?

In case of a fluoxetine overdose, seek medical attention immediately. Symptoms of overdose may include severe dizziness, confusion, changes in heartbeat, fever, fainting, unconsciousness, and seizures. If you suspect an overdose, contact the poison control helpline at 1-800-222-1222 or call emergency services.

Proper Use & Dosage Information for Fluoxetine


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What is the typical starting dose for fluoxetine?

Fluoxetine is available in the following forms:

  • Oral capsules (including delayed-release capsules)
  • Oral tablets
  • Oral solution

The typical starting dose of fluoxetine varies depending on the condition being treated, the severity of symptoms, and individual patient factors. It is crucial to follow your healthcare provider's instructions regarding dosage and administration.

For depression:

  • Oral capsules and tablets: The typical starting dose is 20 mg once daily, taken in the morning. Depending on the response and tolerance, the dosage may be adjusted after several weeks.

For obsessive-compulsive disorder:

  • Oral capsules and tablets: Start with 20 mg once daily. The dose may be gradually increased up to a maximum of 80 mg daily, based on response and tolerance.

For bulimia nervosa:

  • Oral capsules and tablets: The recommended starting dose is 60 mg once daily.

For panic disorder:

  • Oral capsules and tablets: The typical starting dose is 10 mg per day, which may be increased to 20 mg after one week. Further adjustments can be made based on response to the medication.

The dosage may be adjusted based on the response and tolerance to the medication. Your healthcare provider will determine the most appropriate dose based on your medical history, current medications, and response to the medication.

Fluoxetine should be taken exactly as prescribed by your healthcare provider. Do not exceed the recommended dose or duration of treatment without consulting your provider.

If you have any questions about your dosage or need adjustments, contact your healthcare provider for guidance. If you want to talk to a provider right away, consider scheduling an online doctor appointment through a telehealth platform like Sesame.

What should I do if I miss a dose of fluoxetine?

If you miss a dose of fluoxetine, take it as soon as you remember unless it is close to the time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.

Take fluoxetine around the same time every day to ensure effectiveness.

What should I do if I'm feeling better while taking fluoxetine?

Continue taking lamotrigine as prescribed by your healthcare provider, even if you start feeling better. Do not stop the medication abruptly without consulting your provider, as it may lead to a return of symptoms.

If you have any concerns or questions about your medication, discuss them with your healthcare provider for medical advice and recommendations.

How should I store fluoxetine?

Store fluoxetine according to the instructions provided by your healthcare provider or pharmacist. Keep it at room temperature, away from light and moisture. Ensure the container is tightly closed and out of reach of children.

Do not use expired medication or medications that appear damaged or discolored. If you have any questions about storage, consult your healthcare provider or pharmacist for guidance.

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