Medically reviewed by Jessica Swirble, PharmD
Last updated on 7/10/2024

Drug Information | Side Effects | Use & Dosage | Request a Prescription

What are the side effects of glipizide ER?

The use of glipizide ER can lead to various side effects in some individuals.

Common mild side effects of glipizide ER use include:

• Dizziness
  
• Drowsiness
  
• Fatigue
  
• Headache
  
• Nausea
  
• Vomiting
  
• Diarrhea
  
• Constipation
  
• Rash
  
• Tremors
  
• Stomach upset
  
  

More severe side effects of glipizide ER use can include:

• Signs of an allergic reaction (like rash, hives, swelling, difficulty breathing or swallowing)
  
• Hypoglycemia (low blood sugar) with symptoms like sweating, dizziness, confusion, or fainting
  
• Unusual weight gain
  
• Yellowing of skin or eyes (jaundice)
  
• Severe stomach or abdominal pain
  
• Persistent nausea or vomiting
  
• Dark urine
  
• Unusual bleeding or bruising
  
  

If you experience any severe or concerning side effects while taking glipizide ER, contact your healthcare provider right away.

What should I tell my healthcare provider before using glipizide ER?

Inform your healthcare provider about any existing medical conditions, allergies, or other medications you are taking before starting treatment with glipizide ER. This includes prescription drugs, over-the-counter medications, and dietary supplements, as they may interact with glipizide ER.

Tell your provider if you are taking these medications or supplements:

• Beta-blockers
  
• ACE inhibitors
  
• Diuretics
  
• Steroids
  
• Thyroid medications
  
• Birth control pills
  
• Antifungal medications
  
• Blood thinners
  
• NSAIDs (Nonsteroidal Anti-Inflammatory Drugs)
  
• Antidepressants
  
  

You should also mention medical conditions such as:

• Heart disease
  
• Liver disease
  
• Kidney disease
  
• Adrenal or pituitary gland disorders
  
• A history of diabetic ketoacidosis
  
• G6PD deficiency
  
• Thyroid disorders
  
  

If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of using glipizide ER with your healthcare provider.

Are there any other special instructions I should follow?

Take glipizide ER exactly as prescribed by your healthcare provider. Do not exceed the recommended dose or duration of treatment.

Glipizide ER should be taken with a meal to reduce the risk of hypoglycemia.

Monitor your blood sugar levels regularly as instructed by your healthcare provider.

Alcohol may increase the effects of glipizide ER and alcohol. Alcohol should be avoided while taking glipizide ER.

Complete the full course of treatment, even if you feel better, to ensure the medication's effectiveness in managing your condition.

What should I do in case of an overdose?
` In case of a glipizide ER overdose, seek medical attention immediately. Symptoms of overdose may include severe dizziness, fainting, confusion, or rapid heartbeat. If you suspect an overdose, contact the poison control helpline at 1-800-222-1222 or call emergency services.