Medically reviewed by Jessica Swirble, PharmD
Last updated on April 18, 2025
Drug Information | Side Effects | Use & Dosage | Request an Online Prescription
Hydroxychloroquine is a medication used to treat malaria. It may also be used as a preventative measure when other methods have failed. In addition to its use as an anti-malarial medication, hydroxychloroquine may be prescribed as a treatment for rheumatoid arthritis and both chronic discoid lupus erythematosus (chronic inflammation of the skin) and systemic lupus erythematosus (chronic inflammation of the body) in adults.
As an antimalarial medication, hydroxychloroquine is prescribed for the treatment of malaria and as a preventative measure against malaria in parts of the world where chloroquine resistance has not been reported.
In addition to its use as a treatment for malaria, hydroxychloroquine is also indicated for use in adults as a treatment for inflammatory conditions such as rheumatoid arthritis, chronic discoid lupus erythematosus (CLE), and systemic lupus erythematosus (SLE).
Hydroxychloroquine targets the parasitic organism in red blood cells that causes malaria. By killing this pathogen, hydroxychloroquine effectively treats uncomplicated malaria infections. If the disease has become severe or has caused complications, hydroxychloroquine may not be able to treat these conditions. In this case, further medical treatment may be required.
As a treatment for CLE, SLE, and rheumatoid arthritis, hydroxychloroquine works by limiting certain functions of the immune system - which reduces inflammatory responses that cause the symptoms of these conditions.
Hydroxychloroquine is available as an oral tablet. It should be taken with food or milk to minimize stomach upset.
Follow your healthcare provider's instructions regarding dosage and schedule. Do not exceed the prescribed dose or frequency of use without consulting your provider.
Hydroxychloroquine is used to manage malaria, lupus, and rheumatoid arthritis. The effects can be noticeable within a few weeks, but it may take several months to achieve the full therapeutic effect, especially for autoimmune conditions.
Continue using hydroxychloroquine as prescribed, even if you start feeling better. Regular use according to your prescription is crucial for the management of your condition.
While hydroxychloroquine is primarily used for treating malaria, lupus, and rheumatoid arthritis, healthcare providers may prescribe it off-label for other conditions, such as certain skin disorders.
Discuss any alternative uses of hydroxychloroquine with your healthcare provider.
Hydroxychloroquine is available in the following dosage forms:
Hydroxychloroquine is a prescription medication. You must have a valid prescription from a licensed healthcare provider to obtain it.
The use of hydroxychloroquine can lead to various side effects in some individuals.
Common mild side effects of hydroxychloroquine use include:
More severe side effects include:
If you experience any severe or concerning side effects while taking hydroxychloroquine, contact your healthcare provider right away.
Inform your healthcare provider about any existing medical conditions, allergies, or other medications you are taking before starting treatment with hydroxychloroquine. This includes prescription drugs, over-the-counter medications, and dietary supplements, as they may interact with hydroxychloroquine.
Tell your provider if you are taking these medications or supplements:
You should also mention medical conditions such as:
If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of using hydroxychloroquine with your healthcare provider.
Take hydroxychloroquine exactly as prescribed by your healthcare provider. Do not exceed the recommended dose or duration of treatment.
Hydroxychloroquine can cause dizziness or vision changes. Do not drive or operate machinery until you know how this medication affects you.
Complete the full course of treatment, even if you feel better, to ensure the medication's effectiveness in managing your condition.
In case of a hydroxychloroquine overdose, seek medical attention immediately. Symptoms of overdose may include headache, drowsiness, visual disturbances, or convulsions. If you suspect an overdose, contact the poison control helpline at 1-800-222-1222 or call emergency services.
Hydroxychloroquine is available in the following form:
The typical starting dose of hydroxychloroquine varies depending on the condition being treated, the severity of symptoms, and individual patient factors. It is crucial to follow your healthcare provider's instructions regarding dosage and administration.
For malaria:
For lupus:
For rheumatoid arthritis:
The dosage may be adjusted based on the response and tolerance to the medication. Your healthcare provider will determine the most appropriate dose based on your medical history and your response to the medication.
Hydroxychloroquine should be taken as prescribed by your healthcare provider. Do not exceed the recommended dose or duration of treatment without consulting your provider.
If you have any questions about your dosage or need adjustments, contact your healthcare provider for guidance. If you want to talk to a provider right away, consider scheduling an online doctor appointment through a telehealth platform like Sesame.
If you miss a dose of hydroxychloroquine, take it as soon as you remember unless it is close to the time for your next scheduled dose. In that case, skip the missed dose and continue your regular dosing schedule. Do not double the dose to make up for a missed one.
Take hydroxychloroquine around the same time every day to maintain a consistent amount of medication in your body.
Continue taking hydroxychloroquine as prescribed by your healthcare provider, even if you start feeling better. It's important to keep taking the medication as directed to manage your condition effectively.
Do not suddenly stop taking hydroxychloroquine; this can cause a return of your symptoms.
If you have any concerns or questions about your medication, discuss them with your healthcare provider for medical advice and recommendations.
Store hydroxychloroquine according to the instructions provided by your healthcare provider or pharmacist. Keep it at room temperature, away from light and moisture. Ensure the container is tightly closed and out of reach of children.
Do not use expired medication or medications that appear damaged or discolored. If you have any questions about storage, consult your healthcare provider or pharmacist for guidance.