Common Brand Names: Aleve, Naprosyn
Medically reviewed by Jessica Swirble, PharmD
Last updated on April 18, 2025
Drug Information | Side Effects | Use & Dosage | Request an Online Prescription
Naproxen (Naprosyn) is a prescription medication that is used to manage pain and symptoms related to musculoskeletal conditions. These conditions include osteoarthritis, rheumatoid arthritis, ankylosing spondylitis (arthritis that affects the spine), juvenile arthritis (arthritis in children), tendonitis, bursitis, and acute gout. It may also be prescribed to treat pain caused by menstruation.
Non-prescription (over-the-counter) naproxen (Aleve) is used to reduce symptoms of colds, fevers, headaches, and other forms of non-urgent pain.
Naproxen does not cure these conditions. Instead, it helps to relieve symptoms and manage discomfort associated with these conditions.
Prescription naproxen is used to treat pain and inflammation associated with conditions such as:
Over-the-counter naproxen is used to treat pain caused by conditions such as:
Naproxen belongs to a class of medications called nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs work by blocking enzymes called cyclooxygenases (COX), specifically COX-1 and COX-2, which play a pivotal role in producing prostaglandins—chemicals responsible for pain and inflammation. By inhibiting these enzymes, NSAIDs lower the levels of prostaglandins, subsequently alleviating pain and decreasing inflammation.
Naproxen is available as an oral tablet, oral suspension, and extended-release tablet.
Follow your healthcare provider's instructions regarding dosage and schedule. Do not exceed the prescribed dose or frequency of use without consulting your provider.
Naproxen is used to manage pain, inflammation, and stiffness caused by conditions such as arthritis, muscle aches, and menstrual cramps. The effects can be noticeable within a few hours, but optimal relief for chronic conditions may take a few days.
Continue using naproxen as prescribed, even if you start feeling better. Regular use according to your prescription is crucial for the management of your condition.
While naproxen is primarily used to treat pain, inflammation, and stiffness, healthcare providers may prescribe it off-label for other conditions, such as migraines.
Discuss any alternative uses of naproxen with your healthcare provider.
Naproxen is available in the following dosage forms:
Naproxen is available both by prescription and over the counter. To obtain the prescription form, you must have a valid prescription from a licensed healthcare provider.
The use of naproxen can lead to various side effects in some individuals.
Common mild side effects of naproxen use include:
More severe side effects include:
If you experience any severe or concerning side effects while taking naproxen, contact your healthcare provider right away.
Inform your healthcare provider about any existing medical conditions, allergies, or other medications you are taking before starting treatment with naproxen. This includes prescription drugs, over-the-counter medications, and dietary supplements, as they may interact with naproxen.
Tell your provider if you are taking these medications or supplements:
You should also mention medical conditions such as:
If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of using naproxen with your healthcare provider.
Take naproxen exactly as prescribed by your healthcare provider. Do not exceed the recommended dose or duration of treatment.
Your provider may direct you to take naproxen with food or milk to reduce stomach upset.
Naproxen can cause dizziness. Do not drive or operate machinery until you know how this medication affects you.
Complete the full course of treatment, even if you feel better, to ensure the medication's effectiveness in managing your symptoms.
In case of a naproxen overdose, seek medical attention immediately. Symptoms of overdose may include severe stomach pain, nausea, vomiting, drowsiness, or difficulty breathing. If you suspect an overdose, contact the poison control helpline at 1-800-222-1222 or call emergency services.
Naproxen is available in the following forms:
The typical starting dose of naproxen varies depending on the condition being treated, the severity of symptoms, and individual patient factors. It is crucial to follow your healthcare provider's instructions regarding dosage and administration.
For pain and inflammation:
For arthritis:
The dosage may be adjusted based on the response and tolerance to the medication. Your healthcare provider will determine the most appropriate dose based on your medical history and your response to the medication.
Naproxen should be taken as prescribed by your healthcare provider. Do not exceed the recommended dose or duration of treatment without consulting your provider.
If you have any questions about your dosage or need adjustments, contact your healthcare provider for guidance. If you want to talk to a provider right away, consider scheduling an online doctor appointment through a telehealth platform like Sesame.
If you miss a dose of naproxen, take it as soon as you remember unless it is close to the time for your next scheduled dose. In that case, skip the missed dose and continue your regular dosing schedule. Do not double the dose to make up for a missed one.
Take naproxen around the same time every day to maintain a consistent amount of medication in your body.
Continue taking naproxen as prescribed by your healthcare provider, even if you start feeling better. It's important to keep taking the medication as directed to manage your condition effectively.
Do not suddenly stop taking naproxen without consulting your healthcare provider.
If you have any concerns or questions about your medication, discuss them with your healthcare provider for medical advice and recommendations.
Store naproxen according to the instructions provided by your healthcare provider or pharmacist. Keep it at room temperature, away from light and moisture. Ensure the container is tightly closed and out of reach of children.
Do not use expired medication or medications that appear damaged or discolored. If you have any questions about storage, consult your healthcare provider or pharmacist for guidance.