Medically reviewed by Jessica Swirble, PharmD
Last updated on April 17, 2025
Drug Information | Side Effects | Use & Dosage | Request an Online Prescription
Omeprazole is a proton pump inhibitor used primarily to reduce stomach acid production. It works by blocking a specific system within the stomach lining that secretes acid into the stomach. This helps to prevent and heal acid-related damage to the stomach and esophagus and helps reduce symptoms of heartburn and acid reflux.
Omeprazole is primarily used to treat conditions such as:
It is also used in combination with antibiotics to treat and prevent the recurrence of stomach ulcers caused by Helicobacter pylori.
Omeprazole works by irreversibly blocking the proton pump, a key component in the acid secretion mechanism of the gastric parietal cells in the stomach. This leads to a significant reduction in stomach acid output.
Omeprazole can be taken in different forms, depending on specific needs:
The dosage and duration of treatment depend on the condition being treated, its severity, and your response to the medication.
Follow your healthcare provider's instructions regarding dosage and schedule. Do not exceed the prescribed dose or duration of treatment without consulting your provider.
The effectiveness of omeprazole and the time it takes to notice improvement can vary among individuals. Symptom relief, such as reduced heartburn or acid reflux, can be observed within one to two days of starting the medication, but it may take up to four weeks for full therapeutic benefits, especially for healing ulcers or erosive esophagitis.
Continue taking omeprazole as prescribed even if you start feeling better. Do not abruptly stop the medication without consulting your healthcare provider.
While omeprazole is primarily used for managing acid-related disorders, healthcare providers may sometimes prescribe it off-label for conditions such as:
Discuss any alternative uses of omeprazole with your healthcare provider.
Omeprazole is available in the following dosage forms:
Generic versions of omeprazole are available, providing cost-effective treatment options.
Omeprazole is a prescription medication, although certain dosages and forms may be available over the counter. You will need a valid prescription from a licensed healthcare provider to obtain higher dosage forms of this medication.
The use of omeprazole can lead to various side effects in some individuals.
Common mild side effects of omeprazole use include:
More severe side effects of omeprazole use can include:
If you experience any severe or concerning side effects while taking omeprazole, contact your healthcare provider right away.
Tell your healthcare provider about any existing medical conditions, allergies, or other medications you are taking before starting treatment with omeprazole. This includes prescription drugs, over-the-counter medications, and dietary supplements, as they may interact with omeprazole.
Tell your provider if you are taking these medications or supplements:
You should also mention medical conditions such as:
If you are pregnant, planning to become pregnant, or breastfeeding, consult your healthcare provider before using omeprazole to assess potential risks and benefits.
Take omeprazole exactly as prescribed by your healthcare provider. Do not exceed the recommended dose or duration of treatment.
Omeprazole should be taken before meals, preferably in the morning. Swallow the capsules whole; do not crush, chew, or open them.
Avoid alcohol and foods that may trigger your symptoms. Be mindful of your body’s response to different dietary choices and activities.
Store omeprazole at room temperature, away from moisture and heat. Keep it out of reach of children.
In case of an omeprazole overdose, seek medical attention immediately. Symptoms of overdose may include confusion, drowsiness, blurred vision, fast or pounding heartbeats, nausea, vomiting, sweating, flushing, headache, dry mouth, and a faint feeling. If you suspect an overdose, contact the poison control helpline at 1-800-222-1222 or call emergency services.
Omeprazole is available in the following forms:
The typical starting dose of omeprazole varies depending on the condition being treated, the severity of symptoms, and individual patient factors. It is important to follow your healthcare provider's instructions regarding dosage and administration.
For gastroesophageal reflux disease (GERD), the typical starting dose may be:
The dosage may be adjusted based on the response and tolerance to the medication. Your healthcare provider will determine the most appropriate dose based on your medical history, current medications, and response to the medication.
Omeprazole should be taken exactly as prescribed by your healthcare provider. Do not exceed the recommended dose or duration of treatment without consulting your provider.
If you have any questions about your dosage or need adjustments, contact your healthcare provider for guidance. If you want to talk to a provider right away, consider scheduling an online doctor appointment through a platform like Sesame.
If you miss a dose of omeprazole, take it as soon as you remember unless it is close to the time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.
Maintain a consistent dosing schedule to ensure the effectiveness of omeprazole in managing your condition.
Continue taking omeprazole as prescribed by your healthcare provider, even if you start feeling better. Do not stop the medication abruptly without consulting your provider, as it may lead to a recurrence of symptoms or other complications.
Complete the full course of treatment as directed to minimize the risk of relapse.
If you have any concerns or questions about your medication, discuss them with your healthcare provider for personalized guidance and recommendations.
Store omeprazole according to the instructions provided by your healthcare provider or pharmacist. Keep it at room temperature, away from moisture, heat, and light. Ensure the container is tightly closed and out of reach of children.
Do not use expired medication or medications that appear damaged or discolored. If you have any questions about storage, consult your healthcare provider or pharmacist for guidance.