Medically reviewed by Jessica Swirble, PharmD
Last updated on 5/24/2024

Drug Information | Side Effects | Use & Dosage | Request a Prescription

• Brand Name: Zofran
  
• Generic Name: Ondansetron
  
• Uses: Treatment for nausea and vomiting caused by chemotherapy, radiation therapy, and surgery
  
• Drug Class: Serotonin 5-HT3 receptor antagonist
  
• Availability: Prescription only
  
• Generic Status: Yes
  
• Controlled Substance: No
  
  

Ondansetron is a prescription medication used to treat nausea and vomiting caused by surgery, chemotherapy, and radiation treatment.

Ondansetron is used to treat nausea and vomiting caused by surgery, cancer chemotherapy, and radiation treatment.

Ondansetron does not treat underlying causes of nausea and vomiting but reduces these symptoms.

Ondansetron blocks the action of serotonin, a natural chemical in the body that can cause nausea and vomiting. By blocking serotonin receptors in the brain and gut, ondansetron prevents the transmission of nausea signals.

Ondansetron is available in the following forms:

• Oral tablets
  
• Orally disintegrating tablets (ODTs)
  
• Oral solution
  
• Injectable forms
  
  

The dosage and frequency of use depend on the condition being treated, its severity, and how you respond to the medication.

Follow your healthcare provider's instructions regarding dosage and schedule. Do not exceed the prescribed dose or frequency of use without consulting your provider.

You may start feeling better within a few hours of taking ondansetron. It is typically used before, during, and after medical procedures to manage symptoms.

Continue using ondansetron as prescribed, even if you start feeling better. Regular use according to your prescription is crucial for the effective prevention of nausea and vomiting.

While ondansetron is primarily used for preventing nausea and vomiting caused by medical treatments, healthcare providers may prescribe it off-label for other types of nausea and vomiting, such as that associated with gastroenteritis.

Discuss any alternative uses of ondansetron with your healthcare provider.

Ondansetron is available in the following dosage forms:

• Oral tablets
  
• Orally disintegrating tablets (ODTs)
  
• Oral solution
  
• Injectable forms
  
  

Ondansetron is a prescription medication. You will need a valid prescription from a licensed healthcare provider to obtain this medication.