Medically reviewed by Jessica Swirble, PharmD
Last updated on April 21, 2025
Drug Information | Side Effects | Use & Dosage | Request an Online Prescription
Progesterone is a naturally occurring female sex hormone responsible for regulating ovulation and pregnancy and preventing certain diseases (namely uterine cancer). Progesterone also helps regulate functions such as:
As a hormonal supplement, progesterone is commonly prescribed for women who have passed menopause or women who experience irregular menstruation. Progesterone levels are usually at their highest during pregnancy. It is frequently used in birth control pills for this exact reason – it can actually trick the body into not ovulating. Progesterone levels usually start to decrease after menopause, which can lead to an increased risk of ovarian and uterine cancers.
Progesterone is commonly prescribed as a part of hormone replacement therapy, a treatment that supplements low levels of certain hormones. Low levels of progesterone are diagnosed through a blood test.
Common symptoms of low progesterone include:
Progesterone supplements restore hormonal balance in the body and can help the symptoms listed above.
Progesterone is a naturally occurring hormone in the body. However, progesterone is prescribed for individuals who have been diagnosed with hormonal deficiency - meaning that the ovaries and adrenal glands are not producing enough of the hormone.
Progesterone medication works by supplementing low hormonal levels in the body through an oral tablet. These capsules release progesterone into the body, which restores hormonal balance and reduces the symptoms of low progesterone.
Progesterone is available in the following forms:
Follow your healthcare provider's instructions regarding dosage and schedule. Do not exceed the prescribed dose or frequency of use without consulting your provider.
Progesterone is used for hormone replacement therapy, to manage menstrual disorders, and to support pregnancy in women with infertility. You may notice the effects of progesterone within a few weeks of starting treatment. It may take several months to achieve the full effect, especially for hormone-related conditions.
Continue using progesterone as prescribed, even if you start feeling better. Regular use according to your prescription is crucial for the management of your condition.
While progesterone is primarily used for hormone replacement therapy, menstrual disorders, and to support pregnancy, healthcare providers may prescribe it off-label for other conditions, such as to treat premenstrual syndrome (PMS) or to support early pregnancy in women with recurrent miscarriages.
Discuss any alternative uses of progesterone with your healthcare provider.
Progesterone is available in the following dosage forms:
Progesterone is a prescription medication. You must have a valid prescription from a licensed healthcare provider to obtain it.
The use of progesterone can lead to various side effects in some individuals.
Common mild side effects of progesterone use include:
More severe side effects include:
If you experience any severe or concerning side effects while taking progesterone, contact your healthcare provider right away.
Inform your healthcare provider about any existing medical conditions, allergies, or other medications you are taking before starting treatment with progesterone. This includes prescription drugs, over-the-counter medications, and dietary supplements, as they may interact with progesterone.
Tell your provider if you are taking these medications or supplements:
You should also mention medical conditions such as:
If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of using progesterone with your healthcare provider.
Take progesterone exactly as prescribed by your healthcare provider. Do not exceed the recommended dose or duration of treatment.
Progesterone can cause dizziness or drowsiness. Do not drive or operate machinery until you know how this medication affects you.
Complete the full course of treatment, even if you feel better, to ensure the medication's effectiveness in managing your condition.
In case of a progesterone overdose, seek medical attention immediately. Symptoms of overdose may include severe dizziness, nausea, vomiting, or drowsiness. If you suspect an overdose, contact the poison control helpline at 1-800-222-1222 or call emergency services.
Progesterone is available in the following forms:
The typical starting dose of progesterone varies depending on the condition being treated, the severity of symptoms, and individual patient factors. It is crucial to follow your healthcare provider's instructions regarding dosage and administration.
For hormone replacement therapy in people receiving estrogen therapy:
For menstrual disorders:
For supporting pregnancy in women with infertility:
The dosage may be adjusted based on the response and tolerance to the medication. Your healthcare provider will determine the most appropriate dose based on your medical history and your response to the medication.
Progesterone should be taken as prescribed by your healthcare provider. Do not exceed the recommended dose or duration of treatment without consulting your provider.
If you have any questions about your dosage or need adjustments, contact your healthcare provider for guidance. If you want to talk to a provider right away, consider scheduling an online doctor appointment through a telehealth platform like Sesame.
If you miss a dose of progesterone, take it as soon as you remember unless it is close to the time for your next scheduled dose. In that case, skip the missed dose and continue your regular dosing schedule. Do not double the dose to make up for a missed one.
Take progesterone around the same time every day to maintain a consistent amount of medication in your body.
Continue taking progesterone as prescribed by your healthcare provider, even if you start feeling better. It's important to keep taking the medication as directed to manage your condition effectively.
Do not suddenly stop taking progesterone; this can cause a return of your symptoms.
If you have any concerns or questions about your medication, discuss them with your healthcare provider for medical advice and recommendations.
Store progesterone according to the instructions provided by your healthcare provider or pharmacist. Keep it at room temperature, away from light and moisture. Ensure the container is tightly closed and out of reach of children.
Do not use expired medication or medications that appear damaged or discolored. If you have any questions about storage, consult your healthcare provider or pharmacist for guidance.