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Rosuvastatin

Common Brand Names: Crestor, Ezallor

Drug Information

Medically reviewed by Jessica Swirble, PharmD
Last updated on April 2, 2025

Drug Information | Side Effects | Use & Dosage | Request an Online Prescription

Quick facts

  • Brand Name: Crestor, Ezallor
  • Generic Name: Rosuvastatin
  • Uses: Lowering cholesterol and triglyceride levels in the blood
  • Drug Class: Statin
  • Availability: Prescription only
  • Generic Status: Yes
  • Controlled Substance: No

What is rosuvastatin?

Rosuvastatin is a medication classified as a statin, primarily used to lower cholesterol and triglyceride levels in the blood. It belongs to a class of drugs known for their lipid-lowering effects.

What conditions does rosuvastatin treat?

Rosuvastatin is used to treat conditions such as:

  • High cholesterol: Elevated levels of cholesterol in the blood, including LDL (bad) cholesterol and triglycerides
  • Certain genetic lipid disorders: Like heterozygous hypercholesterolemia
  • Hyperlipidemia: Abnormal lipid levels in the blood
  • Atherosclerosis: Buildup of plaque in the arteries, leading to heart disease and stroke risk
  • Reducing the risk of cardiovascular problems: Used to prevent heart attack or stroke in individuals at high risk

It may also be prescribed for other medical conditions related to lipid management as determined by your healthcare provider.

How does rosuvastatin work?

Rosuvastatin works by inhibiting an enzyme in the liver involved in cholesterol production. By reducing cholesterol synthesis, it helps lower LDL cholesterol levels and triglycerides while increasing HDL (good) cholesterol levels.

Rosuvastatin is prescribed in conjunction with a healthy diet and exercise.

How do I take rosuvastatin?

Rosuvastatin is typically taken orally as a tablet, with or without food, as directed by your healthcare provider.

Ezallor capsules should be swallowed whole. Do not crush or chew Ellazor capsules. If you cannot swallow capsules whole, they can be opened and sprinkled on soft food (like applesauce). Stir the mixture for 10-15 seconds and then swallow the mixture without chewing within 60 minutes.

The dosage and duration of treatment depend on your lipid levels, medical history, and response to the medication.

Follow the prescribed dosage and schedule strictly. Do not stop taking rosuvastatin suddenly without consulting your healthcare provider, as it may affect your lipid levels and increase the risk of cardiovascular events.

How long until I feel better?

The time it takes to see noticeable improvements in cholesterol levels can vary among individuals. Some people may experience changes in lipid levels within a few weeks of starting rosuvastatin, while others may require longer-term treatment for optimal results.

Continue taking rosuvastatin as prescribed even if you do not immediately see changes in your cholesterol levels. Regular monitoring and follow-ups with your healthcare provider are important to assess the effectiveness of the medication.

Are there any other uses for rosuvastatin?

While rosuvastatin is primarily used for lipid management, healthcare providers may sometimes prescribe it off-label for other conditions.

Discuss any alternative uses of rosuvastatin with your healthcare provider.

Dosage forms of rosuvastatin

Rosuvastatin is available in the following dosage forms:

  • Oral tablets: Available in various strengths (e.g., 5mg, 10mg, 20mg, 40mg)
  • Sprinkle powder: Available as a powder to sprinkle over food in patients who cannot swallow oral tablets

Generic versions of rosuvastatin are available under various brand names.

Rosuvastatin is a prescription medication. You will need a valid prescription from a licensed healthcare provider to obtain this medication.

Side Effects and Precautions for Rosuvastatin


Drug Information | Side Effects | Use & Dosage | Request an Online Prescription

What are the side effects of rosuvastatin?

The use of rosuvastatin can lead to various side effects in some individuals.

Common mild side effects of rosuvastatin use include:

  • Headache
  • Dizziness
  • Nausea or stomach discomfort
  • Muscle weakness
  • Muscle pain
  • Joint pain
  • Constipation
  • Diarrhea
  • Fatigue
  • Sleep problems (insomnia)

More severe side effects of rosuvastatin use can include:

  • Muscle pain, tenderness, or weakness (especially with fever or unusual tiredness)
  • Liver problems (such as yellowing of the skin or eyes, dark urine, abdominal pain)
  • Allergic reactions (such as rash, itching, swelling of the face, tongue, or throat, trouble breathing)
  • Pancreatitis (severe stomach pain, nausea, vomiting)
  • Memory problems or confusion
  • High blood sugar levels (hyperglycemia)
  • Low levels of platelets in the blood (thrombocytopenia)

If you experience any severe or concerning side effects while taking rosuvastatin, contact your healthcare provider promptly.

What should I tell my healthcare provider before using rosuvastatin?

Tell your healthcare provider about any existing medical conditions, allergies, or other medications you are taking before starting treatment with rosuvastatin. This includes prescription drugs, over-the-counter medications, and dietary supplements, as they may interact with rosuvastatin.

Tell your provider if you are taking these medications or supplements:

  • Other cholesterol medications
  • Blood thinners (anticoagulants)
  • Antibiotics or antifungals
  • Antacids
  • Chemotherapy medications
  • Heart medications
  • HIV/AIDS medications
  • Hepatitis medications
  • Thyroid medications
  • Diabetes medications
  • Immunosuppressant medications

You should also mention medical conditions such as:

  • High blood pressure
  • Heart disease
  • Kidney or liver problems
  • Diabetes
  • Thyroid disorders
  • Muscle disorders
  • Alcohol use disorder
  • Seizure disorder

If you are pregnant, planning to become pregnant, or breastfeeding, consult your healthcare provider before using rosuvastatin to assess potential risks and benefits.

Patients who are of East Asian descent may need dosage adjustments.

Are there any other special instructions I should follow?

Take rosuvastatin with a full glass of water to ensure proper absorption and minimize the risk of stomach upset.

Avoid consuming grapefruit or grapefruit juice while taking rosuvastatin, as it may interact with the medication.

Follow a healthy diet and exercise routine recommended by your healthcare provider to complement the effects of rosuvastatin in lowering cholesterol levels.

Limit alcohol consumption while taking rosuvastatin, as it can increase the risk of liver problems and interfere with the medication's effectiveness.

What should I do in case of an overdose?

In case of a rosuvastatin overdose, seek medical attention immediately. Symptoms of overdose may include severe muscle pain, weakness, or tenderness, nausea, vomiting, and abdominal pain. If you suspect an overdose, contact the poison control helpline at 1-800-222-1222 or call emergency services.

Proper Use & Dosage Information for Rosuvastatin


Drug Information | Side Effects | Use & Dosage | Request an Online Prescription

What is the typical starting dose of rosuvastatin?

Rosuvastatin is available in the following forms:

  • Oral tablets (5mg-40mg)

Typical starting dose for atherosclerosis:

  • 5mg-40mg taken once a day.

Typical starting dose for homozygous hypercholesterolemia:

  • Adults: 5 mg to 40 mg depending on cholesterol levels and risk factors
  • Children between 7-17: 20mg once a day

Typical starting dose for heterozygous hypercholesterolemia:

  • Adults: 5mg-40mg once a day depending on cholesterol levels and risk factors
  • Children between 7-17: 5mg-20mg once a day

Rosuvastatin is available in oral tablet form and should be taken orally with or without food, as directed by your healthcare provider. It is important to take rosuvastatin around the same time every day for optimal effectiveness.

The dosage of rosuvastatin prescribed for you will depend on various factors such as your cholesterol levels, medical history, and response to the medication.

If you have any questions about your dosage or how to take this medication, contact your healthcare provider or pharmacist. If you want to talk to a provider right away, consider booking an online doctor appointment on Sesame to discuss your concerns.

What should I do if I miss a dose of rosuvastatin?

If you miss a dose of rosuvastatin, take it as soon as you remember unless it's almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

What should I do if I'm feeling better while taking rosuvastatin?

Continue taking rosuvastatin as prescribed by your healthcare provider, even if you start feeling better. Maintaining a consistent treatment regimen is essential to effectively managing cholesterol levels. Do not stop taking rosuvastatin without consulting your provider.

How should I store rosuvastatin?

Store rosuvastatin according to the instructions provided by your healthcare provider or pharmacist. Keep it at room temperature, away from moisture, heat, and light. Ensure the container is tightly closed and out of reach of children.

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