New

Get Rybelsus (semaglutide) online prescriptions for weight loss

Rybelsus is used to treat Type 2 diabetes and is also prescribed off-label for weight loss. See if Rybelsus or another GLP-1 medication is right for you.

Rybelsus prescriptions available, if appropriate

Get started
  • Rybelsus (semaglutide) prescriptions available, if appropriate
  • Prescription pickup available at a pharmacy near you
  • Insurance coordination for medication coverage
  • 4.5 on Trustpilot
Sesame’s weight loss program is a month-to-month subscription for individuals who are looking to lose or manage their weight with semaglutide or another weight loss medication. It includes:
  • Medical history review and lifestyle assessment
  • Initial video consult
  • Ongoing care for weight loss and management
  • Unlimited messaging with provider
  • Prescription, if recommended
  • Order for lab(s) relevant to weight loss treatment/diagnoses (excludes NJ, NY, and RI)
  • Cost of lab(s) relevant to weight loss treatment/diagnoses (excludes NJ, NY, and RI)
  • Insurance coordination for prescription authorization
Not included in this subscription:
  • Cost of medication
  • Controlled substance prescription

See how Sesame can help support your health goals.

Choose your own provider

Find the right fit by selecting a board-certified Sesame provider who speaks to you.

Medications made easy

Medication delivered straight to your door or preferred pharmacy.

Support from actual humans

Close clinical supervision focused on sustainable, long-term changes to:

Living with Type 2 diabetes and looking to manage your weight? Sesame can help.

Pick a Sesame provider who’s right for you.

Here's how Success by Sesame works:

1
Tell us about your weight loss history & goals

Answer a few questions to help us personalize your weight loss program, then choose your Sesame provider.

2
Meet with your Sesame provider

Talk to your provider about your medical history and weight loss goals in a video consult. They'll tailor a treatment plan and order a lab test if metabolic data is needed.

3
Begin treatment

Your provider will prescribe a weight loss medication that's right for you (if appropriate). Sesame will send the medication to your door or preferred pharmacy.

4
Ongoing support

Achieve your weight loss goals with unlimited messaging with your chosen provider and follow up visits as needed to monitor progress and adjust treatment.

Let's get started
Product Overview

Rybelsus (semaglutide)

  • What is Rybelsus (semaglutide)?
    Rybelsus (semaglutide) is a prescription drug used to treat type 2 diabetes. The active ingredient in Rybelsus, semaglutide, belongs to a class of medications known as GLP-1s and works by decreasing your body’s blood glucose level and increasing its response to the hormone insulin to get your type 2 diabetes under control. Not only does semaglutide help manage blood sugar levels, but it can also help patients with type 2 diabetes reduce their risk of heart attack, stroke and death.

    Rybelsus is prescribed in conjunction with other treatment measures such as exercise and dietary changes to help patients lose weight and prevent serious complications caused by diabetes. Rybelsus is prescribed in the form of a tablet to be taken orally. Other brand names for semaglutide include Wegovy and Ozempic, which are prescribed in the form of a subcutaneous injection (an injection under the skin).

    Talk to a healthcare provider to see if Rybelsus is right for you. Note that because Rybelsus is not FDA-approved for weight loss it is unlikely that insurance will cover the drug for weight loss.

  • What are the common side effects of Rybelsus (semaglutide)?
    Rybelsus (semaglutide) has been shown to cause some side effects. Talk to your health care provider if these adverse reactions do not go away within a few days.

  • Common side effects reported from Rybelsus (semaglutide) use include:

    ·Nausea
    ·Vomiting
    ·Diarrhea
    ·Abdominal pain
    ·Constipation
    ·Decreased appetite
    ·Heartburn
    ·Burping

This is not a complete list of all possible side effects caused by Rybelsus (semaglutide).

Your provider will help you stay on track.

In 3 monthsMaterial Arrow Forward Icon
Lose 5%of your body weight
In 6 monthsMaterial Arrow Forward Icon
Lose 10%of your body weight
In 12 monthsMaterial Arrow Forward Icon
Lose 15%of your body weight

Results may vary. Milestones are based on semaglutide clinical trial averages.

See how much weight you can lose

Patients love Sesame

Enter your email to get 20% off your first appointment.

Email address


Frequently asked questions about Rybelsus (semaglutide)

Medically reviewed by:Allison Edwards, MD

Rybelsus is a prescription drug used to treat type 2 diabetes. Semaglutide, the active ingredient in Rybelsus, belongs to a class of medications known as glucagon-like peptide-1 (GLP-1) receptor agonists. It decreases your body’s blood glucose levels and increases its response to the hormone insulin to get your type 2 diabetes under control. Not only does semaglutide help manage blood sugar levels, but it can also help patients with type 2 diabetes reduce their risk of heart attack, stroke, and death.

Rybelsus is prescribed in conjunction with other treatment measures such as exercise and dietary changes to help patients prevent serious complications caused by diabetes. Rybelsus is prescribed in the form of a tablet to be taken orally. Other brand names for semaglutide include Wegovy and Ozempic, which are prescribed in the form of a subcutaneous injection (an injection under the skin).

Rybelsus (semaglutide) is used to treat type 2 diabetes.

In people with diabetes, the body either does not produce enough of the hormone insulin or uses it inefficiently. Insulin is needed to help your body absorb glucose when you eat, so when the body isn’t producing enough insulin, blood glucose levels can become too high (hyperglycemia) or too low (hypoglycemia).

Rybelsus is not used to treat type 1 diabetes – an autoimmune condition in which your body attacks your pancreas with antibodies causing the organ to stop producing insulin. If you have been diagnosed with type 1 diabetes, your health care provider will prescribe a different form of medication and therapy for you.

Rybelsus is classified as an incretin mimetic, a category of anti-diabetes medication that acts like incretin hormones (hormones released by the pancreas to stimulate a decrease in blood glucose levels). Rybelsus binds to incretin receptors and prompts your pancreas to produce more insulin. The insulin then helps your body to break down and metabolize glucose in your blood, which keeps your blood sugar levels in check.

Rybelsus has been shown to cause some mild side effects. If these adverse effects do not go away within a few days, talk to your healthcare provider.

Common side effects include:

  • Nausea
  • Vomiting
  • Diarrhea
  • Abdominal pain
  • Constipation
  • Decreased appetite
  • Heartburn
  • Burping

This is not a complete list of possible adverse effects.

If you experience an unexplained rash, swelling, stomach pain, difficulty breathing, decreased urination, changes in vision, or itchy skin while taking Rybelsus, seek medical attention immediately. These are early signs of a potentially serious adverse reaction to the medication reaction.

Talk to your healthcare provider about any medication you are currently taking, or any medical conditions you have been previously diagnosed with before starting treatment with Rybelsus.

Rybelsus comes in the form of an oral tablet which is typically taken once a day on an empty stomach with a sip of water. You should take the tablet 30 minutes before you eat, drink, or take any other medications. However, you should take the medication exactly as prescribed by your healthcare provider. Do not discontinue or increase your Rybelsus dosage without consulting your provider first. If you begin to experience adverse side effects while taking this medication, like those listed above, inform your provider right away.

You should store your medication in a closed container at room temperature, away from extreme heat, extreme cold, moisture, and direct light, and keep it out of the reach of children.

Semaglutide is currently only available via prescription. This means the use of this drug must be authorized by a licensed health care provider.

Note that all prescriptions are at the discretion of your health care provider. Providers on Sesame cannot prescribe controlled substances.

Providers on Sesame can write a prescription for Rybelsus to be picked up near you – often within the same day. Don’t wait to get your prescription filled. Talk to a provider on Sesame and get your prescription ordered right away for fast and convenient pickup from a pharmacy of your choice.

Sesame does not guarantee insurance coverage for medication. If you are uninsured, please be aware that GLP-1 medications like Ozempic, Wegovy and Rybelsus can be expensive, typically ranging between $950 to $1,600 per month. If you are insured, your provider can assist with insurance pre-authorization paperwork to cover the cost of your medication.

No, there are currently no generic alternatives to Rybelsus (semaglutide), although there are other semaglutide medications (Wegovy, Ozempic) on the market.

If you need assistance with navigating your options, you can schedule a video consult with a provider through Sesame’s weight loss program to discuss the best medication for your needs.

Sesame's weight loss program subscription pricing starts at just $89 per month for patients who do not require medication or will purchase their own medication from their preferred pharmacy. This is a good option for eligible Sesame patients who have insurance coverage for name-brand GLP-1 medications, such as Wegovy, Zepbound or Saxenda.

It's important to note that brand-name GLP-1 medications like Wegovy, Zepbound or Saxenda can be expensive without insurance coverage, typically ranging between $950 to $1,600 per month out-of-pocket. If you are insured, your provider can assist with insurance pre-authorization paperwork to help reduce the cost of your medication.

Sesame also offers a weight loss program subscription that includes medication for just $249 per month. This option includes the price of pre-measured, high-quality injectable compounded semaglutide at cost for those who are prescribed it, along with free home delivery.

Note that providers on Sesame set their own prices, which means that some providers may offer the service at a higher price.

Certain GLP-1 therapies such as semaglutide (the active ingredient in Ozempic, Rybelsus, and Wegovy), liraglutide (the active ingredient in Saxenda and Victoza), and tirzepatide (the active ingredient in Mounjaro and Zepbound) may increase the likelihood of developing thyroid gland tumors, including MTC, a type of thyroid cancer. This conclusion is based on studies where laboratory animals given semaglutide, liraglutide, tirzepatide and other GLP-1 medications developed tumors. However, it is not yet confirmed if these medications pose the same risk to humans. You can find additional information about the risks of FDA-approved medications that contain semaglutide here.

It’s important to inform your doctor if you or any family member has ever had MTC or MEN. If this is the case, your doctor will likely advise against taking GLP-1 medications.

If you are prescribed a GLP-1 medication and exhibit any of the following symptoms, you should contact your provider immediately:

  • A lump or swelling in the neck
  • Hoarseness
  • Difficulty swallowing
  • Shortness of breath
  • Severe abdominal pain

Before taking GLP-1 medications, you should also discuss the following with your provider:

Allergies: Inform your doctor and pharmacist of any allergies you have to semaglutide (including under brand names Ozempic, Rybelsus, Wegovy) or similar medications such as tirzepatide (Mounjaro, Zepbound), dulaglutide (Trulicity), exenatide (Bydureon BCise, Byetta), liraglutide (Saxenda, Victoza, or in Xultophy) and lixisenatide (Adlyxin, or in Soliqua).

Personal and family medical history: Be sure to disclose if you have a history of medical conditions like pancreatitis, diabetic retinopathy, gallbladder disease or kidney disease. Inform your doctor about recent episodes of diarrhea, nausea, vomiting or any inability to consume liquids, which could lead to dehydration.

Current medications and supplements: Provide a comprehensive list of all medicines and supplements you are currently taking, including prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products. This is crucial as GLP-1 medications can alter how your body absorbs oral medications.

Pregnancy and breastfeeding: Inform your doctor if you are pregnant, breastfeeding, or planning to become pregnant soon.

Surgical procedures: In the event of surgery, including dental procedures, inform the medical or dental professional that you are on GLP-1 medication.

It's essential to thoroughly discuss these risks with your healthcare provider and consider your personal and family medical history when deciding whether to use these medications. Your doctor can provide guidance on the best course of action based on your specific health situation.

  1. Home
  2. Medication
  3. Rybelsus