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Get Rybelsus (semaglutide) online prescriptions for weight loss

Book with a specialist through Sesame's weight loss program to see if Rybelsus or another GLP-1 medication is right for you.

The cost of medications is not included in the price of this subscription.

  • Rybelsus (semaglutide) prescriptions available, if appropriate
  • Prescription pickup available at a pharmacy near you
  • Insurance coordination for medication coverage
  • 4.3 on Trustpilot
Sesame’s weight loss program is a 3-month subscription which includes:
  • A video consultation with your chosen provider
  • Semaglutide prescription + refills, if clinically appropriate
  • Insurance coordination for prescription authorization
  • Ongoing support via unlimited messaging, nutrition, and exercise guidance
  • Lab order (if needed)
Not included in this subscription:
  • Cost of medication
  • Cost of lab work (if needed)

Book a visit to get started

Choose from top-rated clinicians to kick off your weight loss journey with a video consultation & unlimited messaging.

Product Overview

Rybelsus (semaglutide)

  • What is Rybelsus (semaglutide)?
    Rybelsus (semaglutide) is a prescription drug used to treat type 2 diabetes. The active ingredient in Rybelsus, semaglutide, belongs to a class of medications known as GLP-1s and works by decreasing your body’s blood glucose level and increasing its response to the hormone insulin to get your type 2 diabetes under control. Not only does semaglutide help manage blood sugar levels, but it can also help patients with type 2 diabetes reduce their risk of heart attack, stroke and death.

    Rybelsus is prescribed in conjunction with other treatment measures such as exercise and dietary changes to help patients lose weight and prevent serious complications caused by diabetes. Rybelsus is prescribed in the form of a tablet to be taken orally. Other brand names for semaglutide include Wegovy and Ozempic, which are prescribed in the form of a subcutaneous injection (an injection under the skin).

    Talk to a healthcare provider to see if Rybelsus is right for you. Note that because Rybelsus is not FDA-approved for weight loss it is unlikely that insurance will cover the drug for weight loss.

  • What are the common side effects of Rybelsus (semaglutide)?
    Rybelsus (semaglutide) has been shown to cause some side effects. Talk to your health care provider if these adverse reactions do not go away within a few days.

  • Common side effects reported from Rybelsus (semaglutide) use include:

    ·Nausea
    ·Vomiting
    ·Diarrhea
    ·Abdominal pain
    ·Constipation
    ·Decreased appetite
    ·Heartburn
    ·Burping

This is not a complete list of all possible side effects caused by Rybelsus (semaglutide).

Providers you can trust. Results you can see.

Billed every three months to match your personalized journey.
3 months
Lose up to 5% of your body weightStart treatment and access close monitoring and support to help you meet your goals.
6 months
Lose up to 10% of your body weightTrack progress with your provider via ongoing care and unlimited messaging. Adjust treatment if needed.
12 months
Lose up to 15% of your body weightStay on track and celebrate your success! Connect with your provider to plan how to maintain a healthy weight.

How it works

Get started

Select your provider

Choose a qualified healthcare professional who specializes in weight management.

As soon as today

Meet with your provider

Talk to your provider about your history, weight goals and treatment plan; they’ll order a lab test if you lack recent metabolic data.

Immediately after your appointment

Provider sends Rx (if appropriate)

If medication is prescribed, your provider will handle insurance paperwork and send the prescription to your pharmacy.

Varies by pharmacy

Start treatment

Begin your prescribed weight loss program with the medication or therapy provided.

Ongoing care

Provider support

Begin your prescribed weight loss program with the medication or therapy provided.


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Frequently asked questions about Rybelsus (semaglutide)

Medically reviewed by:Allison Edwards, MD

Rybelsus is a prescription drug used to treat type 2 diabetes. Semaglutide, the active ingredient in Rybelsus, belongs to a class of medications known as glucagon-like peptide-1 (GLP-1) receptor agonists. It decreases your body’s blood glucose levels and increases its response to the hormone insulin to get your type 2 diabetes under control. Not only does semaglutide help manage blood sugar levels, but it can also help patients with type 2 diabetes reduce their risk of heart attack, stroke, and death.

Rybelsus is prescribed in conjunction with other treatment measures such as exercise and dietary changes to help patients prevent serious complications caused by diabetes. Rybelsus is prescribed in the form of a tablet to be taken orally. Other brand names for semaglutide include Wegovy and Ozempic, which are prescribed in the form of a subcutaneous injection (an injection under the skin).

Rybelsus (semaglutide) is used to treat type 2 diabetes.

In people with diabetes, the body either does not produce enough of the hormone insulin or uses it inefficiently. Insulin is needed to help your body absorb glucose when you eat, so when the body isn’t producing enough insulin, blood glucose levels can become too high (hyperglycemia) or too low (hypoglycemia).

Rybelsus is not used to treat type 1 diabetes – an autoimmune condition in which your body attacks your pancreas with antibodies causing the organ to stop producing insulin. If you have been diagnosed with type 1 diabetes, your health care provider will prescribe a different form of medication and therapy for you.

Rybelsus is classified as an incretin mimetic, a category of anti-diabetes medication that acts like incretin hormones (hormones released by the pancreas to stimulate a decrease in blood glucose levels). Rybelsus binds to incretin receptors and prompts your pancreas to produce more insulin. The insulin then helps your body to break down and metabolize glucose in your blood, which keeps your blood sugar levels in check.

Rybelsus has been shown to cause some mild side effects. If these adverse effects do not go away within a few days, talk to your healthcare provider.

Common side effects include:

  • Nausea
  • Vomiting
  • Diarrhea
  • Abdominal pain
  • Constipation
  • Decreased appetite
  • Heartburn
  • Burping

This is not a complete list of possible adverse effects.

If you experience an unexplained rash, swelling, stomach pain, difficulty breathing, decreased urination, changes in vision, or itchy skin while taking Rybelsus, seek medical attention immediately. These are early signs of a potentially serious adverse reaction to the medication reaction.

Talk to your healthcare provider about any medication you are currently taking, or any medical conditions you have been previously diagnosed with before starting treatment with Rybelsus.

Rybelsus comes in the form of an oral tablet which is typically taken once a day on an empty stomach with a sip of water. You should take the tablet 30 minutes before you eat, drink, or take any other medications. However, you should take the medication exactly as prescribed by your healthcare provider. Do not discontinue or increase your Rybelsus dosage without consulting your provider first. If you begin to experience adverse side effects while taking this medication, like those listed above, inform your provider right away.

You should store your medication in a closed container at room temperature, away from extreme heat, extreme cold, moisture, and direct light, and keep it out of the reach of children.

Semaglutide is currently only available via prescription. This means the use of this drug must be authorized by a licensed health care provider.

Note that all prescriptions are at the discretion of your health care provider. Providers on Sesame cannot prescribe controlled substances.

Providers on Sesame can write a prescription for Rybelsus to be picked up near you – often within the same day. Don’t wait to get your prescription filled. Talk to a provider on Sesame and get your prescription ordered right away for fast and convenient pickup from a pharmacy of your choice.

Sesame does not guarantee insurance coverage for medication. If you are uninsured, please be aware that GLP-1 medications like Ozempic, Wegovy and Rybelsus can be expensive, typically ranging between $950 to $1,600 per month. If you are insured, your provider can assist with insurance pre-authorization paperwork to cover the cost of your medication.

No, there are currently no generic alternatives to Rybelsus (semaglutide). Although there are other semaglutide medications (Wegovy, Ozempic) on the market, all GLP-1 agonist drugs are available only as brand-name products.

If you need assistance with navigating your options, you can schedule a video consult with a provider through Sesame’s weight loss program to discuss the best medication for your needs.

Sesame’s online weight loss program is a subscription that renews every 3 months and includes a video consultation with a weight loss provider, a prescription for semaglutide, liraglutide, tirzepatide, or other weight loss medication if deemed clinically appropriate, assistance with pre-authorization for medication coverage, and 90 days of unlimited messaging with your provider.

Sesame does not accept insurance in order to keep prices low and transparent, which means that the cost of the weight program will not be covered by insurance. It's important to note that the cost of medication is not included in this program, and Sesame does not guarantee medication pricing or insurance coverage for medication.

In addition, most insurance companies will not cover the off-label use of prescription drugs. That means you will likely not be able to get insurance coverage if you are prescribed:

  • Ozempic
  • Rybelsus
  • Mounjaro
  • Victoza

If you are uninsured, please be aware that GLP-1 medications like Wegovy can be expensive, typically ranging between $950 to $1,600 per month. If you are insured, your provider can assist with insurance pre-authorization paperwork to cover the cost of your medication.

Your provider may order a metabolic panel if you do not have recent metabolic testing data available. If this is the case, the price of your lab test is not included in the program cost.

Certain GLP-1 therapies such as semaglutide (the active ingredient in Ozempic and Wegovy), liraglutide (the active ingredient in Saxenda and Victoza), and tirzepatide (the active ingredient in Mounjaro and Zepbound) may increase the likelihood of developing thyroid gland tumors, including medullary thyroid carcinoma (MTC), a type of thyroid cancer. This conclusion is based on studies where laboratory animals given semaglutide, liraglutide and tirzepatide developed tumors. However, it is not yet confirmed whether semaglutide, liraglutide and tirzepatide pose the same risk to humans.

It’s important to inform your doctor if you or any family member has ever had MTC or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2), a condition leading to tumors in multiple glands. If this is the case, your doctor will likely advise against taking GLP-1 medications such as semaglutide, tirzepatide or liraglutide.

If you are prescribed a GLP-1 medication such as Ozempic, Wegovy, Mounjaro or Saxenda and exhibit any of the following symptoms, you should contact your provider immediately:

  • A lump or swelling in the neck
  • Hoarseness
  • Difficulty swallowing
  • Shortness of breath

Before taking GLP-1 medications, you should also discuss the following with your provider:

  • Allergies: Inform your doctor and pharmacist of any allergies you have to semaglutide (including under brand names Ozempic, Rybelsus, Wegovy) or similar medications such as tirzepatide (Mounjaro, Zepbound), dulaglutide (Trulicity), exenatide (Bydureon, Byetta), liraglutide (Saxenda, Victoza, or in Xultophy), and lixisenatide (Adlyxin, or in Soliqua).
  • Personal and family medical history: Be sure to disclose if you have a history of conditions like pancreatitis, diabetic retinopathy, gallbladder disease, or kidney disease. Inform your doctor about recent episodes of diarrhea, nausea, or vomiting, or any inability to consume liquids, which could lead to dehydration.
  • Current Medications and Supplements: Provide a comprehensive list of all medicines and supplements you are currently taking, including prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products. This is crucial as GLP-1 medications can alter how your body absorbs oral medications.
  • Pregnancy and Breastfeeding: Inform your doctor if you are pregnant, breastfeeding, or planning to become pregnant soon.
  • Surgical procedures: In the event of surgery, including dental procedures, inform the medical or dental professional that you are on GLP-1 medication.

It's essential to thoroughly discuss these risks with your healthcare provider and consider your personal and family medical history when deciding whether to use these medications. Your doctor can provide guidance on the best course of action based on your specific health situation.

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