Tofacitinib is a prescription medication primarily used to treat autoimmune conditions, including rheumatoid arthritis and ulcerative colitis. It belongs to the drug class known as Janus kinase (JAK) inhibitors and is available under the brand name Xeljanz. No generic version exists.

Tofacitinib targets the underlying causes of autoimmune diseases, helping reduce inflammation and improve the quality of life for individuals with these conditions.

Please note that you will need a prescription from a licensed healthcare provider to obtain this medication.

Tofacitinib is commonly prescribed for the treatment of the following autoimmune conditions:

Rheumatoid Arthritis: Rheumatoid arthritis is a chronic inflammatory disorder that affects the joints, causing pain, swelling, and stiffness. Tofacitinib helps to reduce inflammation and slow down the progression of the disease, providing relief to those with rheumatoid arthritis.

Psoriatic Arthritis: A form of inflammatory arthritis that affects some people who have psoriasis, a chronic skin condition. It causes painful swollen joints and itchy, painful skin rashes. Tofacitinib can improve joint pain and swelling and can improve skin symptoms.

Ulcerative Colitis: Ulcerative colitis is an inflammatory bowel disease that leads to inflammation and ulcers in the colon and rectum. Tofacitinib can help manage symptoms and reduce inflammation in individuals with ulcerative colitis.

Ankylosing Spondylitis: Ankylosing Spondylitis (AS) is a chronic and progressive autoimmune disorder that primarily affects the spine and sacroiliac joints, causing inflammation and stiffness. It is characterized by the gradual fusion of the vertebrae in the spine, leading to a loss of flexibility and mobility.

While using tofacitinib, some individuals may experience side effects, although not everyone will.

Mild side effects may include:

• Headache
  
• Stuffy or runny nose
  
• Diarrhea
  
• High blood pressure
  
• Rash
  
• Elevated cholesterol levels
  
• Upper respiratory tract infections
  
  

More severe side effects are rare but may include:

• Stomach pain
  
• Signs of an allergic reaction (swelling, difficulty breathing, hives, skin rash)
  
• Yellowing skin or eyes
  
• Loss of appetite
  
• Vomiting
  
• Dark colored urine
  
  

It's important to promptly report any side effects or concerns to your healthcare provider.

Before starting treatment with tofacitinib, inform your healthcare provider about any existing medical conditions, allergies, or other medications you are taking, including prescription drugs, over-the-counter medications, and dietary supplements, as they may interact with tofacitinib.

Specifically, discuss any history of:

• Infections
  
• Liver problems
  
• Gastrointestinal issues
  
• Blood disorders
  
• Heart attack, stroke, or blood clots
  
• Heart problems
  
• Cancer
  
• Weakened immune system
  
• Smoking
  
  

Tofacitinib has a black box warning about serious risks associated with this medication. It can increase your risk of serious infections such as pneumonia. Those who have a weakened immune system and those on higher doses are at greater risk. It can also increase your risk of getting blood clots, certain cancers, and other immune system problems. There is also an increased risk of stroke, heart attack, or death, especially in those over 50 with risk factors for heart disease.

If you are pregnant, planning to become pregnant, or breastfeeding, consult your healthcare provider before using tofacitinib to assess potential risks and benefits.

The recommended dosage of tofacitinib may vary depending on the specific condition being treated, individual factors, and your healthcare provider's guidance. It is typically taken orally in tablet form. It comes as an immediate-release tablet and an extended-release tablet.

For rheumatoid arthritis, the usual dosing regimen often involves taking 5 mg tablets twice daily. The initial dosage may vary for ulcerative colitis and ankylosing spondylitis, and your healthcare provider will adjust it based on your response.

Follow your healthcare provider's instructions regarding dosing and other recommendations for taking tofacitinib. Do not discontinue or alter your dosage without consulting your doctor, as this can affect the medication's effectiveness.

Store tofacitinib as directed by your healthcare provider or pharmacist. Proper storage is essential to maintain the medication's effectiveness. Typically, tofacitinib should be stored at room temperature, away from excessive heat, light, and moisture.

Keep the medication out of the reach of children and ensure that the container is tightly closed.

Tofacitinib is available by prescription only. A licensed healthcare provider must authorize the use of this medication.

Looking for a prescription? Providers on Sesame can assess your eligibility and prescribe tofacitinib if it's appropriate for your medical condition and needs. You can arrange for pickup at your pharmacy, depending on the medication. Book an online consultation with a licensed provider on Sesame today to determine whether tofacitinib might be right for you.

Providers on Sesame are unable to prescribe controlled substances.

Providers on Sesame can help you get a prescription for tofacitinib, which you can pick up at a nearby pharmacy. Don't wait to get your prescription filled—talk to a provider on Sesame today to streamline the process for convenient pickup from a pharmacy of your choice.

Note that all prescriptions are at the discretion of your healthcare provider.