Trazodone

Medically reviewed by Jessica Swirble, PharmD
Last updated on 3/28/2024

Drug Information | Side Effects | Use & Dosage | Request a Prescription

• Brand Name: Desyrel, Oleptro
  
• Generic Name: Trazodone
  
• Uses: Treatment of major depressive disorder (MDD), insomnia, and other off-label conditions
  
• Drug Class: Serotonin antagonist and reuptake inhibitor (SARI)
  
• Availability: Prescription only
  
• Generic Status: Yes
  
• Controlled Substance: No
  
  

Trazodone is a medication primarily used to treat major depressive disorder (MDD) and insomnia. It belongs to the class of antidepressants known as serotonin antagonists and reuptake inhibitors (SARIs). Trazodone works by affecting serotonin levels in the brain, helping to improve mood and sleep patterns.

Trazodone is commonly prescribed to manage symptoms of depression—also known as major depressive disorder (MDD).

Trazodone works by blocking the reuptake of serotonin in the brain. This action helps regulate mood and emotions, contributing to its antidepressant effects. Additionally, trazodone can help insomnia by promoting relaxation and sleep.

It's important to note that trazodone should be taken as prescribed by your healthcare provider and not stopped abruptly, as discontinuation without proper guidance can lead to withdrawal symptoms.

Trazodone is typically taken orally in tablet form, with or without food. The dosage and frequency of administration will be determined by your healthcare provider based on your medical condition and response to treatment. It's crucial to follow the prescribed dosage and instructions carefully.

For insomnia, trazodone is usually taken shortly before bedtime to aid in sleep initiation and maintenance.

Consult your healthcare provider for specific instructions on how to take trazodone properly.

The effects of trazodone on mood and sleep patterns may vary from person to person. Some individuals may experience improvements in depressive symptoms within a few weeks of starting treatment, while others may require several weeks for noticeable changes.

Similarly, trazodone's effectiveness in treating insomnia may be observed shortly after starting treatment, but noticeable results may take time. Consistent use of trazodone as directed by your healthcare provider is essential for achieving desired outcomes.

In addition to treating MDD, trazodone may have other off-label uses, including:

1. Insomnia: Trazodone has sedative properties and may be used to treat insomnia in some patients.

2. Anxiety disorders: Trazodone may be prescribed to manage symptoms of anxiety disorders, such as generalized anxiety disorder (GAD) or panic disorder.

3. Schizophrenia: Trazodone may be prescribed to treat symptoms of schizophrenia.

4. Post-traumatic stress disorder (PTSD): Trazodone might be used as part of a comprehensive treatment plan for individuals with PTSD, helping alleviate sleep disturbances and certain anxiety symptoms.

5. Fibromyalgia: Trazodone may be considered in managing sleep difficulties and associated symptoms in individuals with fibromyalgia.

Discuss any alternative uses of trazodone with your healthcare provider.

Trazodone is available as an oral tablet in various strengths, including 50mg, 100mg, 150mg, and 300mg. The dosage prescribed will depend on the specific condition being treated and individual factors.

Generic versions of trazodone are available under different brand names.

Trazodone is a prescription medication and a valid prescription from a licensed healthcare provider is required to obtain this drug.