Ozempic (semaglutide) is an injectable medication used to lower blood sugar levels in people with type 2 diabetes. However, it is perhaps even more famous for its off-label use as a weight-loss drug for patients with overweight or obesity who also have weight-related health problems. Semaglutide, the medication in Ozempic, is also the active ingredient in the FDA-approved medication Wegovy. Using Ozempic has been linked to other effects, not all of which are undesirable.

In addition to its ability to lower blood sugar and help with weight management, studies show that Ozempic reduces the risk of heart disease, stroke, and heart attacks. Read on to learn more about the cardiovascular benefits of Ozempic.

Does Ozempic lower blood pressure?

A 2023 review of six studies found that Ozempic significantly reduced blood pressure. These studies were conducted in people with type 2 diabetes and people with obesity who do not have type 2 diabetes. The mean (average) blood pressure of this group was within the normal range. Ultimately, taking Ozempic led to a 5 mmHg reduction in systolic blood pressure and a 2.5 mm Hg reduction in diastolic blood pressure. This effect stayed consistent even at higher doses.

Another review of eight clinical trials involving patients taking either semaglutide or liraglutide (a similar type of medication) found similar results to the 2023 review.

It should be noted that in both studies, the authors do not draw a direct relationship between Ozempic and lowered blood pressure. Weight loss from Ozempic use, along with increased physical activity and reduced salt intake, all contribute to lowered blood pressure.

Its effect on patients with hypertension still needs more research. But, the authors of the review conclude that its effect may be even greater in these people.

Are there other cardiovascular benefits of Ozempic?

The U.S. Food and Drug Administration (FDA) has approved Ozempic to reduce the risk of heart problems (like a heart attack or stroke), or death in patients with type 2 diabetes mellitus (also known as type heart attack, stroke, or death in patients with type 2 diabetes). It is thought to do this primarily by managing blood sugar levels and helping patients lose weight.

Ozempic contains semaglutide, a drug in the GLP-1 receptor agonist family. These diabetes medications work by mimicking glucagon-like peptide-1 (GLP-1), a hormone produced by the endocrine system in response to eating. GLP-1 encourages the pancreas to make insulin, which controls blood glucose (blood sugar) levels. GLP-1 also signals to the brain that you’re full after eating.

By acting like the GLP-1 hormone, semaglutide helps patients with type 2 diabetes control their blood sugar levels. It also helps patients reduce their body weight by making them feel more full after eating (preventing overeating).

Excess body weight (overweight) and high blood sugar levels increase the risk of high blood pressure, heart disease, and cardiovascular events like a heart attack or stroke. Reducing both body weight and blood sugar levels can reduce the risk of heart problems.

How does weight loss help your heart health?

People with overweight or obesity are at a greater risk of many health problems, including the increased risk of high blood pressure, high cholesterol, and heart disease. Excess body weight makes your heart work harder to pump blood throughout the body. In addition, too much cholesterol and fatty tissue in the body causes material (known as arterial plaque) to build up in the arteries. This leads to blood vessels narrowing, making it even harder for oxygen-rich blood to flow to and from the heart.

Losing weight helps reverse plaque buildup from the arteries, making it easier for the heart to send blood throughout the body.

According to the American Heart Association, losing even a little bit of weight goes a long way. Cutting your body weight by 5-10% can reduce your risk of weight-related heart problems. For someone who is 200 pounds, that means losing as little as 10 pounds.

Can I get an Ozempic prescription for high blood pressure?

It is not likely that you will be prescribed Ozempic just to lower your blood pressure, as it is not FDA-approved for treating hypertension. Healthcare providers prescribe Ozempic to patients with type 2 diabetes. They also sometimes prescribe it off-label to patients with overweight or obesity who have other weight-related health problems.

If you have type 2 diabetes and high blood pressure, talk to your healthcare provider about Ozempic. If you do not have type 2 diabetes but are overweight or obese, talk to your provider. Ask about weight loss drugs that might be right for you.

• Obesity is defined as: A body mass index—BMI—of 30 kg/m2 or greater)
  
• Overweight is defined as: A BMI of 27 kg/m2 or greater
  
  

These drugs are expensive. Ozempic costs about $935 per month. Many insurance plans do not cover any part of Ozempic if you do not have type 2 diabetes, meaning you have to pay that entire price out-of-pocket. Because of this, you should discuss alternative options with your healthcare provider to find the best solution for you.

Alternatives to Ozempic include:

1. Wegovy (semaglutide): Wegovy is made by the same company as Ozempic, Novo Nordisk. It contains a higher dose of semaglutide and may be more effective at helping patients lose weight. Wegovy is supplied as a subcutaneous injection pen that should be used once a week.

2. Zepbound (tirzepatide): Zepbound, like Wegovy, is specifically approved as a weight loss medication. It is a more potent form of the type 2 diabetes drug Mounjaro. Zepbound is supplied as a subcutaneous injection pen that is used once a week.

These drugs are only available in their brand-name form. There is no generic version of either drug, and you must have a prescription to get them. Talk to your provider about the benefits and risks of weight loss medication before starting treatment.

Common side effects of Ozempic include:

• Stomach pain
  
• Nausea
  
• Diarrhea
  
• Constipation
  
  

Less common but more severe side effects include:

• Pancreatitis (inflammation of the pancreas)
  
• Low blood sugar (hypoglycemia)
  
• Vision changes
  
• Increased risk of thyroid cancer or tumors
  
• Allergic reactions like skin rash, swelling, breathing difficulties
  
  

If you are looking to manage your blood pressure but do not have type 2 diabetes, your provider may recommend a blood pressure medication to manage your condition.

How Sesame can help

If you’re looking to treat high blood pressure, Sesame can help. Talk to a provider online to discuss your concerns and potential treatment options for your condition. Providers on Sesame can answer your questions while offering medical advice, guidance about lifestyle changes, and prescribing medication if appropriate. If you want to speak to a provider about weight loss, Sesame offers a comprehensive online weight loss program to help you get started on your weight loss journey.

Sesame’s online weight loss program is a subscription that renews every 3 months and includes a video consultation with a weight loss doctor or specialist, a GLP-1 prescription (if appropriate), insurance coordination for medication coverage, and 90 days of unlimited messaging with your provider.

Note that all prescriptions are at the discretion of your healthcare provider.

Sources:

• (2024). Lose Weight and Lower Heart Disease Risk. American Heart Association.
  
• (2024). How Overweight and Obesity Impacts Your Health. CDC.
  
• (2024). Medications Containing Semaglutide Marketed for Type 2 Diabetes or Weight Loss. FDA.
  
• Kennedy C, Hayes P, Salama S, Hennessy M, Fogacci F. The Effect of Semaglutide on Blood Pressure in Patients without Diabetes: A Systematic Review and Meta-Analysis. J Clin Med.
  
• Stewart J, Brown K, Kendrick D, Dyas J; Nottingham Dibetes and Blood Pressure Study Group. Understanding of blood pressure by people with type 2 diabetes: a primary care focus group study. Br J Gen Pract.
  
• Wu W, Tong HM, Li YS, Cui J. The effect of semaglutide on blood pressure in patients with type-2 diabetes: a systematic review and meta-analysis. Endocrine.
  

Sesame content is not intended to be a substitute for professional medical advice, diagnosis or treatment. If you have a medical concern, it is critical to seek the advice of your physician or another qualified health provider with any questions. If you are facing a medical emergency, call 911 or visit the nearest emergency room immediately.

Editorial policy

Sesame's Editorial Team is committed to delivering useful, relevant and reliable health information to our readers. Our editorial policy ensures that all content is thoroughly researched and medically reviewed to maintain high standards of accuracy and integrity. For more details on our commitment and practices, please visit our Editorial Process and Review Standards Policy page.