Medically reviewed by Jessica Swirble, PharmD
Last updated on 5/24/2024

Drug Information | Side Effects | Use & Dosage | Request a Prescription

The use of acetaminophen can lead to various side effects in some individuals.

Common mild side effects of acetaminophen use include:

• Nausea
  
• Upset stomach
  
• Vomiting
  
• Loss of appetite
  
• Headache
  
• Dizziness or lightheadedness
  
• Sweating
  
  

More severe side effects of acetaminophen use can include:

• Skin rash
  
• Swelling (mainly in the face, hands, ankles, legs, or feet)
  
• Hives
  
• Red, blistering, or peeling skin
  
• Insomnia
  
• Fatigue
  
• Difficulty breathing or swallowing
  
• Severe nausea and vomiting
  
• Yellowing of the skin or eyes, dark urine, pain in the abdomen
  
  

If you experience any severe or concerning side effects while taking acetaminophen, contact your healthcare provider right away.

Inform your healthcare provider about any existing medical conditions, allergies, or other medications you are taking before starting treatment with acetaminophen. This includes prescription drugs, over-the-counter medications, and dietary supplements, as they may interact with acetaminophen.

Tell your provider if you are taking these medications or have these conditions:

• Other pain relievers or fever reducers
  
• Blood thinning medications
  
  

You should also mention medical conditions such as:

• Liver disease or a history of liver problems
  
• Kidney disease
  
• Diabetes
  
• High blood pressure
  
  

People who drink more than three alcoholic drinks a day should not use acetaminophen. Acetaminophen can interact with alcohol in the body, causing potentially serious side effects. If you regularly consume alcohol, talk to a healthcare provider before you take acetaminophen.

If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of using acetaminophen with your healthcare provider.

Take acetaminophen exactly as directed on the package. Do not exceed the recommended dose or duration of treatment.

Acetaminophen can be taken with or without food, but taking it with food may help reduce stomach upset.

In case of an acetaminophen overdose, seek medical attention immediately. Symptoms of overdose may include nausea, vomiting, loss of appetite, confusion, jaundice (yellowing of the skin or eyes), and severe pain in the upper stomach. If you suspect an overdose, contact the poison control helpline at 1-800-222-1222 or call emergency services.