Medically reviewed by Jessica Swirble, PharmD
Last updated on 4/18/2024

Drug Information | Side Effects | Use & Dosage | Request a Prescription

The use of amoxicillin can lead to various side effects in some individuals. These side effects can range from mild to severe and may require medical attention depending on their severity.

Common mild side effects of amoxicillin use include:

• Nausea
  
• Diarrhea
  
• Vomiting
  
• Skin rash or itching
  
  

More severe side effects of amoxicillin use can include:

• Severe diarrhea (with or without blood)
  
• Severe skin reactions (such as blistering or peeling)
  
• Difficulty breathing or swallowing
  
• Hives
  
• Swelling
  
  

If you experience any severe side effects while taking amoxicillin, seek immediate medical attention.

Inform your healthcare provider about any existing medical conditions, allergies, or other medications you are taking before starting treatment with amoxicillin. This includes prescription drugs, over-the-counter medications, and dietary supplements, as they may interact with amoxicillin.

Tell your provider if you are taking these medications or supplements:

• Probenecid
  
• Allopurinol
  
• Anticoagulants (like warfarin)
  
• Birth control pills (amoxicillin may reduce their effectiveness)
  
• Cephalorin antibiotics
  
• Methotrexate (used to treat certain cancers and autoimmune diseases)
  
  

Mention medical conditions such as:

• Kidney disease
  
• Liver disease
  
• Mononucleosis
  
• Allergies (especially to penicillin or other antibiotics)
  
• Asthma
  
• Phenylketonuria (PKU)
  
  

If you are pregnant, planning to become pregnant, or breastfeeding, consult your healthcare provider before using amoxicillin to assess potential risks and benefits.

Amoxicillin can be taken with or without food. Take the medication around the same time every day.

Swallow amoxicillin tablets or capsules whole with a full glass of water.

Limit alcohol consumption while taking amoxicillin, as it may increase the risk of side effects.

Take the full course of treatment, even if you are feeling better. Do not discontinue the use of amoxicillin or increase your dosage without consulting your healthcare provider.

In case of an amoxicillin overdose, seek immediate medical attention. Symptoms may include severe nausea, vomiting, diarrhea, and abdominal cramping. If you experience any of these symptoms, call the poison control helpline at 1-800-222-1222. If an individual has collapsed, is having seizures, or is unresponsive, call 9-1-1 immediately.