Medically reviewed by Jessica Swirble, PharmD
Last updated on 5/24/2024

Drug Information | Side Effects | Use & Dosage | Request a Prescription

The use of aripiprazole can lead to various side effects in some individuals.

Common mild side effects of aripiprazole use include:

• Headache
  
• Anxiety/ Restlessness
  
• Fatigue
  
• Dizziness
  
• Drowsiness
  
• Heartburn
  
• Stomach pain
  
• Nausea
  
• Weight gain
  
• Constipation
  
• Diarrhea
  
• Vomiting
  
• Changes in appetite
  
• Insomnia
  
• Joint pain
  
  

More severe side effects of aripiprazole use can include:

• Symptoms of an allergic reaction (like skin rash, swelling, difficulty breathing or swallowing)
  
• Seizures
  
• Tremors or uncontrollable movements in the face, arms, or legs
  
• Muscle stiffness, fever, sweating, confusion, or feeling faint
  
• Fast or irregular heartbeat
  
• Chills
  
• Weakness
  
• High cholesterol
  
• Unusual bleeding or bruising
  
• Increased thirst or increased urination
  
• High blood sugar
  
• Dry mouth
  
  

If you experience any severe or concerning side effects while taking aripiprazole, contact your healthcare provider right away.

Inform your healthcare provider about any existing medical conditions, allergies, or other medications you are taking before starting treatment with aripiprazole. This includes prescription drugs, over-the-counter medications, and dietary supplements, as they may interact with aripiprazole.

Tell your provider if you are taking these medications or supplements:

• Allergy medications
  
• Strong CYP3A4 Inhibitors (such as clarithromycin)
  
• Strong CYP2D6 inhibitors (such as fluoxetine)
  
• Strong CYP3A4 Inducers (such as carbamazepine)
  
• Blood pressure medications
  
• Benzodiazepines
  
• Seizure medications
  
• Pain medications
  
• Medications for depression
  
• Medications for sleep disorders
  
  

You should also mention medical conditions such as:

• Heart disease
  
• Heart failure
  
• Heart attack
  
• Irregular heartbeat
  
• High or low blood pressure
  
• Stroke
  
• Ministroke
  
• Seizures
  
• Low white blood cell counts
  
• High cholesterol
  
• Balance problems
  
• Conditions that make it difficult for you to swallow
  
  

If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of using aripiprazole with your healthcare provider.

Take aripiprazole exactly as prescribed by your healthcare provider. Do not exceed the recommended dose or length of treatment.

Do not drive a car or operate machinery until you know how aripiprazole affects you.

Do not drink alcohol while using aripiprazole.

This medication can make you more sensitive to extreme temperatures. Talk to your provider if you plan to be in very hot or very cold temperatures. Drink plenty of water and other fluids while taking aripiprazole.

Aripiprazole can be taken with or without food. Taking it with food may help reduce stomach upset. It's important to follow your healthcare provider's instructions and complete the full course of treatment to effectively manage your condition.

In case of an aripiprazole overdose, seek medical attention immediately. Symptoms of overdose may include severe drowsiness, rapid or unusual movements, dizziness, or fainting. If you suspect an overdose, contact the poison control helpline at 1-800-222-1222 or call emergency services.