Medically reviewed by Jessica Swirble, PharmD
Last updated on 5/16/2024

Drug Information | Side Effects | Use & Dosage | Request a Prescription

The use of azithromycin can lead to various side effects in some individuals.

Common mild side effects of azithromycin use include:

• Diarrhea
  
• Nausea and vomiting
  
• Abdominal pain
  
• Headache
  
  

More severe side effects of azithromycin use can include:

• Allergic reactions (difficulty breathing, rash, hives, itching, swelling)
  
• Jaundice (yellowing of the skin or eyes)
  
• Severe diarrhea (potentially with blood)
  
• Heart palpitations (fast or pounding heartbeats) or chest pain
  
• Hearing problems
  
  

If you experience any severe or concerning side effects while taking azithromycin, contact your healthcare provider right away.

Tell your healthcare provider about any existing medical conditions, allergies, or other medications you are taking before starting treatment with azithromycin. This includes prescription drugs, over-the-counter medications, and dietary supplements, as they may interact with azithromycin.

Tell your provider if you are taking these medications or supplements:

• Antacids that contain aluminum or magnesium
  
• Warfarin
  
• Ergotamine or dihydroergotamine
  
• Antibiotics
  
• Medications for depression or mood disorders
  
• Heart rhythm medications
  
• Nausea medications
  
• Statins (drugs that are used to treat high cholesterol levels)
  
  

You should also mention medical conditions such as:

• Liver disease
  
• Kidney disease
  
• Heart rhythm disorders
  
• Heart problems
  
• Blood infections
  
• Low levels of magnesium or potassium
  
• Myasthenia gravis
  
• Cystic fibrosis
  
• Prolonged QT syndrome
  
  

If you are pregnant, planning to become pregnant, or breastfeeding, consult your healthcare provider before using azithromycin to assess potential risks and benefits.

Take azithromycin exactly as prescribed by your healthcare provider. Do not exceed the recommended dose or duration of treatment.

Azithromycin can be taken with or without food, though taking it with food may reduce stomach upset. It's important to complete the full course of treatment, even if you start feeling better, to prevent the return of antibiotic-resistant bacteria.

In case of an azithromycin overdose, seek medical attention immediately. Symptoms of overdose may include severe nausea, vomiting, diarrhea, or hearing loss. If you suspect an overdose, contact the poison control helpline at 1-800-222-1222 or call emergency services.