Medically reviewed by Jessica Swirble, PharmD
Last updated on 4/18/2024

Drug Information | Side Effects | Use & Dosage | Request a Prescription

Bupropion is available in various strengths, including:

• Oral tablets (75 mg, 100 mg)
  
• Extended-release tablets (150 mg, 300 mg, 450 mg)
  
• Sustained-release tablets (100 mg, 150 mg, 200 mg)
  
  

The typical starting dose of bupropion for depression, seasonal affective disorder (SAD), smoking cessation, and other conditions can vary depending on factors such as the specific condition being treated, your age, other medical conditions, and how you respond to the medication. It's crucial to follow your healthcare provider's instructions regarding dosage and administration carefully.

For most adults with depression or SAD, the typical starting dose of bupropion may be:

• 100 mg taken orally twice daily for immediate-release tablets
  
• 150 mg taken orally once daily for extended-release tablets and sustained-release tablets
  
  

For smoking cessation, the typical starting dose of bupropion may also be:

• 150 mg taken orally once daily for sustained-release tablets
  
  

However, your healthcare provider may start with a lower dose, such as 75 mg for immediate-release tablets, especially for older adults or those with certain medical conditions. The dose may then be gradually increased based on your response and tolerability, up to a maximum of 400 mg (for sustained-release) to 450 mg (for extended-release) per day for depression and 300 mg per day for SAD and smoking cessation.

Bupropion can be taken with or without food, but it's important to take it consistently at the same time each day.

Your healthcare provider will monitor your response to bupropion and may adjust the dose as needed. It's important not to exceed the recommended dose or make changes to your dosage without consulting your healthcare provider.

If you have any questions about your dosage or how to take bupropion, contact your healthcare provider or pharmacist. If you want to talk to a provider right away, consider booking an online doctor appointment on Sesame to discuss your concerns.

If you miss a dose of bupropion, take it as soon as you remember. If it's close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule. Avoid taking a double dose of bupropion to make up for a missed one.

Continue taking bupropion as prescribed by your healthcare provider, even if you start feeling better. Abruptly stopping bupropion can lead to withdrawal symptoms and potential relapse of symptoms. Follow your provider's instructions regarding the duration of treatment.

Store bupropion according to the instructions provided by your healthcare provider or pharmacist. It should be kept at room temperature, away from excessive heat, light, and moisture. Ensure the container is tightly closed and keep the medication out of the reach of children.