Some of the most common side effects associated with cefixime include diarrhea
stomach pain, gas, heartburn, nausea, and vomiting.
This is not a complete list of adverse effects – though these are among the most common. Seek medical attention right away if you experience symptoms such as watery or bloody stools, stomach cramps, or fever during treatment, rash, itching, hives, difficulty breathing or swallowing, wheezing, swelling of the face, throat, tongue, lips, and eyes, or a return of sore throat, fever, chills, or other signs of infection while taking cefixime.
Cefixime can impact the readings of certain blood sugar tests for diabetes, so be sure to use Clinistix or TesTape (not Clinitest) during urine tests.
As with all prescription medication, be sure to inform the prescribing doctor about any medical conditions you have been previously diagnosed with, as well as any medication/ supplements you are currently taking before starting treatment with cefixime. Cefixime can interact with other forms of medication and substances, causing potentially serious side effects. Be sure to let your doctor know if you’re taking any other cephalosporin antibiotics such as cefaclor (Ceclor), cefadroxil cefazolin (Ancef, Kefzol), cefdinir, cefditoren (Spectracef), cefepime (Maxipime), cefotaxime (Claforan), cefotetan, cefoxitin (Mefoxin), cefpodoxime, cefprozil, ceftaroline (Teflaro), ceftazidime (Fortaz, Tazicef, in Avycaz), ceftibuten (Cedax), ceftriaxone (Rocephin), cefuroxime (Zinacef), or cephalexin (Keflex), as these may impact your treatment’s effectiveness.
You should also let your doctor know if you are taking any anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven), or carbamazepine (Carbatrol, Epito, Equetro, Tegretol, Teril), as these medications can interact with cefixime and cause potentially dangerous or life-threatening side effects.
In addition, let your doctor know if you are pregnant or plan on becoming pregnant before starting treatment with this medication.