Clindamycin

Drug Information

Medically reviewed by Jessica Swirble, PharmD
Last updated on April 2, 2025

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Quick facts

• Brand Name: Cleocin, ClindaMax, Clindesse, Clinda-Derm, Clindagel, Clindets, Evoclin
• Generic Name: Clindamycin
• Uses: Bacterial infections
• Drug Class: Lincosamide antibiotic
• Availability: Prescription only
• Generic Status: Yes
• Controlled Substance: No

What is clindamycin?

Clindamycin is an antibiotic medication classified as a lincosamide antibiotic. It is primarily used to treat various bacterial infections caused by susceptible organisms.

What conditions does clindamycin treat?

Clindamycin is used to treat conditions such as:

• Skin and soft tissue infections: Including acne, cellulitis, abscesses, and wound infections
• Respiratory tract infections: Such as pneumonia and bronchitis
• Blood infections
• Vaginal infections
• Pelvic infections: Including pelvic inflammatory disease (PID)

It may also be prescribed for other bacterial infections as determined by your healthcare provider.

How does clindamycin work?

Clindamycin works by inhibiting bacterial protein synthesis, thereby preventing the growth and spread of bacteria.

How do I take clindamycin?

Clindamycin is usually taken orally as capsules or tablets, or it may be administered intravenously in severe infections. It is also available in topical form.

The dosage and duration of treatment depend on the type and severity of the infection, as well as your response to the medication.

Follow the prescribed dosage and schedule strictly. Do not stop taking clindamycin suddenly without consulting your healthcare provider, as it may lead to the development of antibiotic resistance or a relapse of your infection.

How long until I feel better?

The time it takes to see improvement with clindamycin can vary depending on the type of infection being treated and your overall health condition. In general, you may start to experience relief from symptoms within a few days of starting treatment. However, it's essential to complete the full course of antibiotics as prescribed, even if you start feeling better earlier.

Are there any other uses for clindamycin?

While clindamycin is primarily used for bacterial infections, healthcare providers may sometimes prescribe it off-label for other conditions.

Discuss any alternative uses of clindamycin with your healthcare provider.

Dosage forms of clindamycin

Clindamycin is available in the following dosage forms:

• Oral capsules and tablets: Available in various strengths (e.g., 150mg, 300mg)
• Oral solution (reconstituted)
• Intravenous (IV) injection: For severe infections requiring hospitalization
• Topical: Topical clindamycin is used for acne

Generic versions of clindamycin are available under various brand names.

Clindamycin is a prescription medication. You will need a valid prescription from a licensed healthcare provider to obtain this medication.

Side Effects and Precautions for Clindamycin

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What are the side effects of clindamycin?

The use of clindamycin, whether in oral or topical form, can lead to various side effects in some individuals.

Common mild side effects of clindamycin use include:

• Nausea
• Vomiting
• Diarrhea
• Stomach pain
• Heartburn
• Loss of appetite
• Skin rash or itching (for topical use)
• Dry or peeling skin (for topical use)
• Throat irritation or soreness (for topical use)

More severe side effects of clindamycin use can include:

• Severe diarrhea
• Abdominal pain
• Allergic reactions, such as hives, itching, swelling of the face or throat, difficulty breathing (for both oral and topical use)
• Severe skin reactions, including blistering, peeling, or a severe rash (for both oral and topical use)
• Yellowing of the skin or eyes (jaundice)
• Dark urine
• Unusual tiredness
• Changes in bowel habits, such as bloody or watery stools
• Difficulty swallowing or breathing (for topical use if accidentally ingested)
• Tingling or numbness in the hands or feet
• Unusual vaginal discharge or itching (for topical use)

If you experience any severe side effects while using clindamycin, especially those that indicate an allergic reaction or severe skin reaction, seek medical attention immediately.

What should I tell my healthcare provider before using clindamycin?

Before using clindamycin, it's important to inform your healthcare provider about any existing medical conditions, allergies, or medications you are currently taking. This includes prescription drugs, over-the-counter medications, and dietary supplements, as they may interact with clindamycin.

Tell your provider if you are taking the following medications or supplements:

• Any other antibiotics
• Drugs that impact intestinal health or digestion
• Nonsteroidal anti-inflammatory drugs (NSAIDs)
• Blood thinners (anticoagulants)
• Muscle relaxants
• Herbal supplements like St. John's wort or others

Mention any medical conditions you have, such as:

• Gastrointestinal disorders or history of intestinal issues (like Crohn’s disease or colitis)
• Allergic reactions to antibiotics or related medications
• Blood clotting disorders or history of bleeding complications
• Liver or kidney conditions
• Asthma
• Eczema
• Allergies

If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of using clindamycin with your healthcare provider.

Are there any other special instructions I should follow?

For oral clindamycin:

• Taking clindamycin with food can help reduce the risk of GI distress (like an upset stomach). Talk to your provider about any foods you should avoid while taking clindamycin.

For topical clindamycin:

• Apply topical clindamycin according to the instructions provided by your healthcare provider or pharmacist. Use a thin layer on clean, dry skin.
• Avoid getting topical clindamycin into your eyes, mouth, or nose. If accidental contact occurs, rinse thoroughly with water.

What should I do in case of an overdose?

In case of a clindamycin overdose, seek medical attention immediately. Symptoms of overdose may include severe diarrhea, vomiting, or abdominal pain. If you suspect an overdose, contact the poison control helpline at 1-800-222-1222 or call emergency services.

Proper Use & Dosage Information for Clindamycin

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What is the typical starting dose for clindamycin?

Clindamycin is available in various forms, including:

• Oral capsules (75 mg, 150 mg, 300 mg)
• Oral solution (75 mg/5 mL)
• Topical gel or solution (1%)
• Topical foam or lotion (1%)

The typical starting dose of clindamycin for bacterial infections can vary depending on factors such as the type of infection, its severity, your age, and other medical conditions. It's crucial to follow your healthcare provider's instructions regarding dosage and administration carefully.

For most adults and children with bacterial infections, the typical starting dose of clindamycin may be:

• 150 mg to 300 mg taken orally every 6 to 8 hours for capsules or oral solution.

For topical use, a thin layer of clindamycin gel, solution, foam, or lotion is typically applied to the affected area(s) twice daily.

The dose for pediatric patients is based on weight and the specific infection being treated, and the oral solution is often used for pediatric dosing.

Clindamycin should be taken with a full glass of water to ensure proper absorption. It should be administered with food to minimize stomach upset.

Your healthcare provider will determine the duration of treatment based on the type of infection and your response to the medication. It's important to complete the full course of treatment as prescribed, even if your symptoms improve before the medication is finished.

If you have any questions about your dosage or how to take clindamycin, contact your healthcare provider or pharmacist. If you want to talk to a provider right away, consider booking an online doctor appointment on Sesame to discuss your concerns.

What should I do if I miss a dose of clindamycin?

If you miss a dose of oral clindamycin, take it as soon as you remember. If it's almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

For topical clindamycin, apply it as soon as you remember. If it's almost time for your next application, skip the missed dose and continue with your regular schedule.

What should I do if I'm feeling better while taking clindamycin?

Continue taking oral clindamycin as prescribed by your healthcare provider, even if you start feeling better. Abruptly stopping clindamycin can lead to the recurrence of bacterial infections or antibiotic resistance. Follow your provider's instructions regarding the duration of treatment.

How should I store clindamycin?

Store oral clindamycin according to the instructions provided by your healthcare provider or pharmacist. It should be kept at room temperature, away from moisture, heat, and light. Ensure the container is tightly closed and keep the medication out of the reach of children.

For topical clindamycin, store it at room temperature as well, and keep it tightly closed. Avoid exposing it to extreme temperatures or direct sunlight.