Colesevelam is a prescription medication used to lower cholesterol levels and improve glycemic control in individuals with type 2 diabetes. It is available under the brand name Welchol.

Generic versions are also available. Colesevelam belongs to the drug class known as bile acid sequestrants, which bind to bile acids in the intestines, ultimately reducing cholesterol absorption and improving blood sugar control.

Please note that you will need a prescription from a licensed healthcare provider to obtain this medication.

Colesevelam is prescribed to manage the following medical conditions:

High Cholesterol: It is used to lower elevated levels of LDL cholesterol, also known as "bad" cholesterol, in adults with primary hyperlipidemia (high cholesterol).

Even though cholesterol plays a critical role in healthy cell function, this type of cholesterol can build up when produced in excess. When extra cholesterol accumulates, it turns into plaque. This plaque coats the walls of arteries and blood vessels, making it harder for blood to flow throughout the body.

This restricted blood flow can lead to complications such as:

• Heart disease
  
• Stroke
  
• Peripheral artery disease (PAD)
  
• Chest pain (angina)
  
• Heart attack
  
• High blood pressure
  
• Reduced blood flow to organs
  
• Increased risk of blood clots
  
  

Type 2 Diabetes: Colesevelam is also used to improve glycemic control in adults with type 2 diabetes when used as an adjunct to diet and exercise.

Type 2 diabetes is a chronic metabolic disorder characterized by elevated blood glucose levels, also called “blood sugar.” It is a complex condition with multiple causes, and its development involves a combination of genetic, lifestyle, and environmental factors.

While using colesevelam, some individuals may experience side effects, although not everyone will.

Mild side effects may include:

• Constipation
  
• Upset stomach or indigestion
  
• Heartburn
  
• Nausea
  
• Gas
  
• Diarrhea
  
• Weakness
  
• Muscle pain
  
  

More severe side effects include:

• Severe abdominal pain
  
• Vomiting
  
• Pancreatitis
  
• Severe constipation or bowel blockage
  
  

It's important to inform your healthcare provider if you experience any side effects or have concerns about taking this medication.

Before starting treatment with colesevelam, inform your healthcare provider about any existing medical conditions, allergies, or other medications you are taking, including prescription drugs, over-the-counter medications, and dietary supplements, as they may interact with colesevelam.

Specifically, discuss any history of:

• Bowel obstructions
  
• Swallowing difficulties
  
• Gastroparesis (a condition that affects stomach emptying)
  
• High triglyceride levels
  
• Vitamin deficiencies
  
• Hypertriglyceridemia-induced pancreatitis
  
• Phenylketonuria (PKU), as colesevelam may contain phenylalanine
  
  

Colesevelam can bind with other medications that you may take. Other medication should be taken at least 4 hours before colesevelam.

If you are pregnant, planning to become pregnant, or breastfeeding, consult your healthcare provider before using colesevelam to assess potential risks and benefits.

The recommended dosage of colesevelam may vary depending on the specific medical condition being treated, individual factors, and your healthcare provider's guidance. It is typically taken orally in tablet or powder form.

For high cholesterol, the usual dose is taken once or twice daily with meals. For type 2 diabetes, the dosing regimen may vary based on your healthcare provider's instructions.

For powdered colesevelam, mix the medication with 8 ounces of water or fruit juice.

Follow your healthcare provider's instructions regarding dosing and other recommendations for taking colesevelam. Do not discontinue or alter your dosage without consulting your doctor, as this can affect the medication's effectiveness.

Store colesevelam as directed by your healthcare provider or pharmacist. Proper storage is essential to maintain the medication's effectiveness. Typically, colesevelam should be stored at room temperature, away from excessive heat, light, and moisture.

Keep the medication out of the reach of children and ensure that the container is tightly closed.

Colesevelam is available by prescription only. A licensed healthcare provider must authorize the use of this medication.

Looking for a prescription? Providers on Sesame can assess your eligibility and prescribe colesevelam if it's appropriate for your medical condition and needs. You can arrange for pickup at your pharmacy, depending on the medication. Book an online consultation with a licensed provider on Sesame today to determine whether colesevelam might be right for you.

Providers on Sesame are unable to prescribe controlled substances.

Note that all prescriptions are at the discretion of your healthcare provider. Sesame cannot guarantee that you will be provided a prescription after a video or in-person appointment.

Providers on Sesame can assist you with obtaining a prescription for colesevelam, which you can pick up at a nearby pharmacy. Don't wait to get your prescription filled—talk to a provider on Sesame today to streamline the process for convenient pickup from a pharmacy of your choice.

Note that all prescriptions are at the discretion of your healthcare provider.