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Dexamethasone

Common Brand Names: Decadron

Drug Information

Medically reviewed by Jessica Swirble, PharmD
Last updated on April 18, 2025

Drug Information | Side Effects | Use & Dosage | Request an Online Prescription

Quick facts:

  • Brand Name: Decadron
  • Generic Name: Dexamethasone
  • Uses: Treatment for inflammation, allergic reactions, certain types of arthritis, and other medical conditions
  • Drug Class: Corticosteroid
  • Availability: Prescription only
  • Generic Status: Yes
  • Controlled Substance: No

What is dexamethasone?

Dexamethasone is a corticosteroid, a medicated form of the naturally occurring hormones produced by the adrenal glands (two small glands located above your kidneys). These glands produce corticosteroids that regulate inflammation, metabolism, stress responses, blood pressure, and blood sugar levels. Dexamethasone is specifically used to treat inflammation and inflammatory conditions in various body parts.

What is dexamethasone used to treat?

Dexamethasone is used to treat inflammation and inflammatory conditions in various parts of the body.

This includes:

  • Rheumatoid arthritis
  • Osteoarthritis
  • Gout
  • Bursitis
  • Tendinitis
  • Lupus
  • Inflammatory bowel disease
  • Allergic rhinitis
  • Asthma symptoms
  • Psoriasis
  • Eczema

This is not a complete list of all conditions that dexamethasone is used to treat.

How does dexamethasone work?

Dexamethasone is classified as a corticosteroid. It is the synthesized version of naturally occurring hormones produced by the adrenal glands, which help regulate several functions in the body. Corticosteroid medications stop your immune system from overreacting to triggers by blocking specific proteins that cause swelling and inflammation.

How do I take dexamethasone?

Dexamethasone is available in the following forms:

  • Oral tablets
  • Oral solution
  • Topical creams/ointments
  • Ophthalmic (eye) drops

The dosage and frequency of use depend on the condition being treated, its severity, and how you respond to the medication.

Follow your healthcare provider's instructions regarding dosage and schedule. Do not exceed the prescribed dose or frequency of use without consulting your provider.

How long until I feel better?

The time it takes to feel better can vary depending on the condition being treated and individual response to the medication. Some people may start noticing improvements within a few hours, while for others, it might take several days.

Continue using dexamethasone as prescribed, even if you start feeling better. Regular use according to your prescription is crucial for effectively managing your condition.

Are there any other uses for dexamethasone?

While dexamethasone is primarily used for treating inflammation, allergic reactions, and certain types of arthritis, healthcare providers may prescribe it off-label for other conditions, such as severe asthma attacks, or as part of chemotherapy treatment.

Discuss any alternative uses of dexamethasone with your healthcare provider.

Dosage forms of dexamethasone

Dexamethasone is available in the following dosage forms:

  • Oral tablets
  • Oral solution
  • Topical creams/ointments
  • Ophthalmic (eye) drops

Dexamethasone is a prescription medication. You will need a valid prescription from a licensed healthcare provider to obtain this medication.

Side Effects and Precautions for Dexamethasone


Drug Information | Side Effects | Use & Dosage | Request an Online Prescription

What are the side effects of dexamethasone?

The use of dexamethasone can lead to various side effects in some individuals.

Common mild side effects of dexamethasone use include:

  • Stomach irritation/ upset stomach
  • Nausea
  • Vomiting
  • Dizziness
  • Fatigue
  • Anxiety
  • Irritability
  • Nervousness/ restlessness
  • Acne
  • Increased hunger
  • Increased blood sugar
  • High blood pressure

More severe side effects of dexamethasone use can include:

  • Swelling in the face, ankles, or legs
  • Skin rash/ hives
  • Difficulty breathing
  • Wheezing
  • Weight gain
  • Muscle weakness
  • Osteoporosis
  • Black or tarry stools
  • Infections
  • Cataracts and glaucoma

If you experience any severe or concerning side effects while taking dexamethasone, contact your healthcare provider right away.

What should I tell my healthcare provider before using dexamethasone?

Inform your healthcare provider about any existing medical conditions, allergies, or other medications you are taking before starting treatment with dexamethasone. This includes prescription drugs, over-the-counter medications, and dietary supplements, as they may interact with dexamethasone.

Tell your provider if you are taking these medications or supplements:

  • Anticoagulants
  • Arthritis medications
  • Nonsteroidal anti-inflammatory drugs (NSAIDs)
  • Hormone therapy
  • Diuretics
  • Oral contraceptives (birth control pills)
  • Heart rhythm medications
  • Immunosuppressant medications

You should also mention medical conditions such as:

  • Kidney or liver disease
  • Intestinal conditions
  • Heart disease
  • Diabetes
  • Thyroid conditions
  • High blood pressure
  • Mental health conditions
  • Myasthenia gravis
  • Osteoporosis
  • Herpes infection of the eye
  • Seizures
  • Tuberculosis
  • Stomach ulcers
  • Glaucoma or cataracts

If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of using dexamethasone with your healthcare provider.

Are there any other special instructions I should follow?

Take dexamethasone exactly as prescribed by your healthcare provider. Do not exceed the recommended dose or length of treatment.

You may be asked to eat a low-salt, high-potassium, and high-protein diet while taking dexamethasone.

Dexamethasone should be taken with food or milk to help reduce stomach upset. To ensure the medication's effectiveness, it's important to complete the full course of treatment, especially if it's part of a scheduled regimen for conditions like inflammation or autoimmune disorders.

What should I do in case of an overdose?

In case of a dexamethasone overdose, seek medical attention immediately. Symptoms of overdose may include severe drowsiness, rapid weight gain, swelling, or severe dizziness. If you suspect an overdose, contact the poison control helpline at 1-800-222-1222 or call emergency services.

Proper Use & Dosage Information for Dexamethasone


Drug Information | Side Effects | Use & Dosage | Request an Online Prescription

What is the typical starting dose for dexamethasone?

Dexamethasone is available in the following forms:

  • Oral tablets
  • Oral solution
  • Topical creams/ointments
  • Ophthalmic (eye) drops

The typical starting dose of dexamethasone varies depending on the condition being treated, the severity of symptoms, and individual patient factors. It is crucial to follow your healthcare provider's instructions regarding dosage and administration.

For inflammatory and autoimmune conditions:

  • Adults: 0.75 to 9 mg per day, depending on the specific condition and tolerance to treatment.
  • Children: Dosage is based on body weight and must be determined by your doctor.

The dosage may be adjusted based on the response and tolerance to the medication. Your healthcare provider will determine the most appropriate dose based on your medical history and your response to the medication.

Dexamethasone should be taken as prescribed by your healthcare provider. Do not exceed the recommended dose or duration of treatment without consulting your provider.

If you have any questions about your dosage or need adjustments, contact your healthcare provider for guidance. If you want to talk to a provider right away, consider scheduling an online doctor appointment through a telehealth platform like Sesame.

What should I do if I miss a dose of dexamethasone?

If you miss a dose of dexamethasone, take it as soon as you remember unless it is close to the time for your next scheduled dose. In that case, skip the missed dose and continue your regular dosing schedule. Do not double the dose to make up for a missed one.

Take dexamethasone around the same time every day to maintain an even level of medication in your body.

What should I do if I'm feeling better while taking dexamethasone?

Continue taking dexamethasone as prescribed by your healthcare provider, even if you start feeling better. It's important to keep taking the medication as directed to manage your condition effectively.

If you have any concerns or questions about your medication, discuss them with your healthcare provider for medical advice and recommendations.

How should I store dexamethasone?

Store dexamethasone according to the instructions provided by your healthcare provider or pharmacist. Keep it at room temperature, away from light and moisture. Ensure the container is tightly closed and out of reach of children.

Do not use expired medication or medications that appear damaged or discolored. If you have any questions about storage, consult your healthcare provider or pharmacist for guidance.

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