Sesame Logo

Get a doxepin prescription online for depression and more

  • Same-day prescriptions
  • Local pharmacy pick-up
  • Rx discount card available

Speak to a provider on Sesame to discuss if doxepin is right for you. Doxepin is a tricyclic antidepressant (TCA) approved to treat major depressive disorder (MDD), anxiety, and insomnia (at low doses).

This medication can help you:

  • Improve your sleep
  • Relieve depression symptoms
  • Reduce anxiety associated with mood disorders

Get a prescription now

Why get a doxepin prescription online through Sesame?

Get a prescription today

Browse top-rated providers, available now.

See a doctor or provider today to discuss a new prescription or refill.

About doxepin

Learn more about doxepin, what it's used to treat, and how you can get a doxepin prescription today.
Get a prescription today

How to get a doxepin prescription online through Sesame?

1
Book a visit with your choice of provider

Find quality providers and specialists at a time that works for you. Read reviews, check prices, and book a same-day video visit for a transparent, upfront fee.

2
Meet with your provider

Connect with your provider during a face-to-face video visit and discuss your medical history, sleep patterns, or mood symptoms. Your provider will establish a personalized treatment plan.

3
Pick up your prescription as soon as today

Your provider will send your prescription directly to your chosen local pharmacy if it is clinically appropriate for you.

1
Book a visit with your choice of provider

Find quality providers and specialists at a time that works for you. Read reviews, check prices, and book a same-day video visit for a transparent, upfront fee.

2
Meet with your provider

Connect with your provider during a face-to-face video visit and discuss your medical history, sleep patterns, or mood symptoms. Your provider will establish a personalized treatment plan.

3
Pick up your prescription as soon as today

Your provider will send your prescription directly to your chosen local pharmacy if it is clinically appropriate for you.

Book a visit today

How doxepin may affect you

Learn about potential side effects and when to seek medical care.

See if this medication is right for you

Patients love Sesame

Frequently asked questions

About doxepin prescriptions

Avatar image
Medically reviewed by:Jessica Swirble, PharmD
Doxepin is a prescription-only medication and not available over the counter. You can, however, consult a provider online. If appropriate, your provider can write you a prescription for doxepin to be picked up at your local pharmacy.
Yes, at low doses like 3 mg and 6 mg, doxepin is FDA-approved to treat insomnia caused by trouble staying asleep throughout the night. Unlike many traditional sleeping pills, low-dose doxepin is not habit-forming.
No, doxepin is not a controlled substance. Its potential for abuse, physical dependence, and addiction is low compared to traditional sleep medications like benzodiazepines.
There are several classes of medications used to treat anxiety and depression. Among them are selective serotonin reuptake inhibitors (SSRIs like sertraline or escitalopram), serotonin-norepinephrine reuptake inhibitors (SNRIs like duloxetine or venlafaxine), and tricyclic antidepressants (TCAs like higher-dose doxepin or amitriptyline). Your provider will determine the best option based on your symptoms.

The recommended dose for adult insomnia patients is 3 mg to 6 mg taken once a day within 30 minutes of bedtime. For elderly patients (65 and older) or those with hepatic impairment (reduction or loss of regular liver function), the recommended starting dose is 3 mg once a day.

Prescribed for depression or anxiety, starting doses typically range from 25 mg to 75 mg per day.

For insomnia, the daily dose should not exceed 6 mg. Taking higher doses increases the risk of drowsiness and grogginess the next day.
When taken for insomnia, the most common side effects are grogginess, nausea, upper respiratory tract infections, dry mouth, dizziness, and mild fatigue. If you take doxepin within 3 hours of a high-fat meal, its effectiveness may be delayed and next-day sleepiness increased.
Doxepin interacts with monoamine oxidase inhibitors (MAOIs), which is why you should not take these two medications within 14 days of each other. It also interacts with alcohol, sedating antihistamines, and other central nervous system (CNS) depressants, which increase sedation. Cimetidine can increase doxepin levels in the blood, and combining doxepin with heart rhythm medications can increase the risk of heart problems.
Do not take doxepin if you have untreated narrow-angle glaucoma, severe sleep apnea, severe urinary retention, or a known allergy to dibenzoxepines. Tell your provider if you have a history of depression or suicidal thoughts, liver disease, or heart conditions, or if you are pregnant or breastfeeding.
If you take doxepin for sleep and miss your bedtime dose, skip it and take your normal prescribed dose the next night. Never double up on tablets. If you take doxepin for depression or anxiety, take it as soon as you remember and only skip it if it's close to your next dose.
Taking too much doxepin can lead to severe CNS depression, extreme sleepiness, low blood pressure, seizures, confusion, hallucinations, rapid or irregular heart rate, or coma. Seek emergency medical care immediately if you suspect an overdose.
Store your doxepin tablets at room temperature between 68°F and 77°F. Keep them protected from excessive heat, light, and moisture, and store them out of reach of children and pets.

Other medications

Duloxetine dr
Paroxetine
Bupropion xl
Effexor
Bupropion sr
Citalopram
Lurasidone
Phenelzine
Imipramine
Find a doctor or provider
Sesamecare logo
Sesame is accredited by Better Business BureauVerify LegitScript Approval
© 2026 Sesame, Inc. All rights reserved.