Medically reviewed by Jessica Swirble, PharmD
Last updated on 4/19/2024

Drug Information | Side Effects | Use & Dosage | Request a Prescription

The use of doxycycline can lead to various side effects in some individuals. These side effects can range from mild to severe and may require medical attention depending on their severity.

Common mild side effects of doxycycline use include:

• Stomach upset or pain
  
• Nausea
  
• Mild diarrhea
  
• Loss of appetite
  
• Skin rash or itching
  
• Headache
  
• Vaginal rash or itching
  
• Changes in skin color
  
  

More severe side effects of doxycycline use can include:

• Severe headache or blurred vision
  
• Severe skin reactions (such as blistering or peeling)
  
• Skin rash with a fever
  
• Abnormal bleeding or bruising
  
• Sore throat
  
• Severe diarrhea
  
• Joint pain
  
• Signs of a serious allergic reaction (e.g., swelling of the face or throat, difficulty breathing)
  
  

If you experience any severe side effects while taking doxycycline, seek immediate medical attention.

Tell your healthcare provider about any existing medical conditions, allergies, or other medications you are taking before starting treatment with doxycycline. This includes prescription drugs, over-the-counter medications, and dietary supplements, as they may interact with this drug.

Tell your provider if you are taking these medications or supplements:

• Acitretin
  
• Anticoagulants
  
• Penicillin antibiotics
  
• Other antibiotics
  
• Retinoids
  
• Birth control pills
  
• Methotrexate
  
• Digoxin
  
• Proton pump inhibitors
  
  

You should also mention medical conditions such as:

• Liver disease
  
• Kidney disease
  
• Lupus
  
• Diabetes
  
• Increased pressure in your skull
  
• Asthma
  
  

If you are pregnant, planning to become pregnant, or breastfeeding, consult your healthcare provider before using doxycycline to assess potential risks and benefits.

Take doxycycline with a full glass of water to prevent irritation of the esophagus.

Avoid lying down for at least 30 minutes after taking the medication to prevent throat irritation and ensure proper absorption.

Do not take doxycycline with dairy products, calcium supplements, antacids, zinc, or iron supplements, as they can interfere with its absorption.

Limit exposure to sunlight and ultraviolet (UV) light while taking doxycycline, as it can increase the risk of sunburn.

Use effective contraception methods while taking doxycycline, as it may reduce the effectiveness of hormonal birth control pills.

In case of a doxycycline overdose, symptoms may include severe nausea, vomiting, diarrhea, and dizziness. If you experience any of these symptoms, call the poison control helpline at 1-800-222-1222. If an individual has collapsed, is having seizures, or is unresponsive, call 9-1-1 immediately.