Medically reviewed by Jessica Swirble, PharmD
Last updated on April 18, 2025
Drug Information | Side Effects | Use & Dosage | Request an Online Prescription
Ezetimibe is a prescription medication used to reduce high cholesterol levels in the blood. It works by blocking the absorption of cholesterol from the intestines, which helps lower LDL ("bad") cholesterol levels and raise HDL ("good") cholesterol levels.
Ezetimibe is typically used to treat high cholesterol and certain other lipids in the blood, such as triglycerides. It can also be used in combination with statins or other medications to treat familial hypercholesterolemia (FH), which is a genetic disorder that causes very high levels of cholesterol in the blood.
High cholesterol can lead to serious health problems, such as heart attacks and strokes. To keep cholesterol under control, ezetimibe is usually prescribed along with lifestyle changes, such as a low-cholesterol, low-saturated fat diet.
Ezetimibe belongs to a class of medications known as cholesterol absorption inhibitors. These drugs work by preventing the absorption of cholesterol in the intestine. This makes it easier for your body to clear LDL cholesterol and other fats from the body.
Ezetimibe is available as an oral tablet.
The dosage and frequency of use depend on the condition being treated, its severity, and how you respond to the medication.
Follow your healthcare provider's instructions regarding dosage and schedule. Do not exceed the prescribed dose or frequency of use without consulting your provider.
Ezetimibe is used to manage high cholesterol. The effects can be noticeable within a few weeks, but it may take up to two weeks for the desired reduction in cholesterol levels to occur.
Continue using ezetimibe as prescribed, even if you start feeling better. Regular use according to your prescription is crucial for the management of your cholesterol levels.
While ezetimibe is primarily used for treating high cholesterol, healthcare providers may prescribe it off-label for other conditions.
Discuss any alternative uses of ezetimibe with your healthcare provider.
Ezetimibe is available in the following dosage forms:
Ezetimibe is a prescription medication. You must have a valid prescription from a licensed healthcare provider to obtain it.
The use of ezetimibe can lead to various side effects in some individuals.
Common mild side effects of ezetimibe use include:
More severe side effects of ezetimibe use can include:
If you experience any severe or concerning side effects while taking ezetimibe, contact your healthcare provider right away.
Inform your healthcare provider about any existing medical conditions, allergies, or other medications you are taking before starting treatment with ezetimibe. This includes prescription drugs, over-the-counter medications, and dietary supplements, as they may interact with ezetimibe.
Tell your provider if you are taking these medications or supplements:
You should also mention medical conditions such as:
If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of using ezetimibe with your healthcare provider.
Take ezetimibe exactly as prescribed by your healthcare provider. Do not exceed the recommended dose or duration of treatment.
Your provider may direct you to maintain a healthy diet and exercise regimen while taking ezetimibe to maximize its effectiveness in lowering cholesterol.
Complete the full course of treatment, even if you feel better, to ensure the medication's effectiveness in managing your condition.
In case of an ezetimibe overdose, seek medical attention immediately. Symptoms of overdose may include severe stomach pain, nausea, vomiting, or dizziness. If you suspect an overdose, contact the poison control helpline at 1-800-222-1222 or call emergency services.
Ezetimibe is available in the following form:
The typical starting dose of ezetimibe varies depending on the condition being treated, the severity of symptoms, and individual patient factors. It is crucial to follow your healthcare provider's instructions regarding dosage and administration.
For high cholesterol:
The dosage may be adjusted based on the response and tolerance to the medication. Your healthcare provider will determine the most appropriate dose based on your medical history and your response to the medication.
Ezetimibe should be taken as prescribed by your healthcare provider. Do not exceed the recommended dose or duration of treatment without consulting your provider.
If you have any questions about your dosage or need adjustments, contact your healthcare provider for guidance. If you want to talk to a provider right away, consider scheduling an online doctor appointment through a telehealth platform like Sesame.
If you miss a dose of ezetimibe, take it as soon as you remember unless it is close to the time for your next scheduled dose. In that case, skip the missed dose and continue your regular dosing schedule. Do not double the dose to make up for a missed one.
Take ezetimibe around the same time every day to maintain a consistent amount of medication in your body.
Continue taking ezetimibe as prescribed by your healthcare provider, even if you start feeling better. It's important to keep taking the medication as directed to manage your condition effectively.
Do not suddenly stop taking ezetimibe; this can cause your cholesterol levels to rise again.
If you have any concerns or questions about your medication, discuss them with your healthcare provider for medical advice and recommendations.
Store ezetimibe according to the instructions provided by your healthcare provider or pharmacist. Keep it at room temperature, away from light and moisture. Ensure the container is tightly closed and out of reach of children.
Do not use expired medication or medications that appear damaged or discolored. If you have any questions about storage, consult your healthcare provider or pharmacist for guidance.