Medically reviewed by Jessica Swirble, PharmD
Last updated on 6/6/2024

Drug Information | Side Effects | Use & Dosage | Request a Prescription

The use of ezetimibe can lead to various side effects in some individuals.

Common mild side effects of ezetimibe use include:

• Headache
  
• Dizziness
  
• Diarrhea
  
• Sore throat
  
• Runny nose
  
• Sneezing
  
• Joint pain
  
• Fatigue
  
• Abdominal pain
  
  

More severe side effects of ezetimibe use can include:

• Hives
  
• Rash
  
• Itching
  
• Difficulty breathing or swallowing
  
• Swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
  
• Hoarseness
  
• Upset stomach
  
• Extreme tiredness
  
• Unusual bleeding or bruising
  
• Lack of energy
  
• Loss of appetite
  
• Pain in the upper right part of the stomach
  
• Yellowing of the skin or eyes
  
• Flu-like symptoms
  
• Muscle pain or weakness
  
• Fever
  
• Chills
  
• Pale or fatty stools
  
• Chest pain
  
  

If you experience any severe or concerning side effects while taking ezetimibe, contact your healthcare provider right away.

Inform your healthcare provider about any existing medical conditions, allergies, or other medications you are taking before starting treatment with ezetimibe. This includes prescription drugs, over-the-counter medications, and dietary supplements, as they may interact with ezetimibe.

Tell your provider if you are taking these medications or supplements:

• Cyclosporine
  
• Fenofibric acid
  
• Gemfibrozil
  
• Cholestyramine
  
• Colesevelam
  
• Blood thinning medication
  
  

You should also mention medical conditions such as:

• Liver disease
  
• Kidney disease
  
  

If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of using ezetimibe with your healthcare provider.

Take ezetimibe exactly as prescribed by your healthcare provider. Do not exceed the recommended dose or duration of treatment.

Your provider may direct you to maintain a healthy diet and exercise regimen while taking ezetimibe to maximize its effectiveness in lowering cholesterol.

Complete the full course of treatment, even if you feel better, to ensure the medication's effectiveness in managing your condition.

In case of an ezetimibe overdose, seek medical attention immediately. Symptoms of overdose may include severe stomach pain, nausea, vomiting, or dizziness. If you suspect an overdose, contact the poison control helpline at 1-800-222-1222 or call emergency services.