Medically reviewed by Jessica Swirble, PharmD
Last updated on 4/20/2024

Drug Information | Side Effects | Use & Dosage | Request a Prescription

The use of fluticasone, whether in inhalant or nasal spray form, can lead to various side effects in some individuals.

Common mild side effects of fluticasone use include:
For Inhalant Form:

• Throat irritation
  
• Hoarseness
  
• Dry mouth or throat
  
• Cough
  
• Headache
  
• Fatigue
  
• Nausea
  
• Nosebleeds (epistaxis)
  
• Oral thrush
  
  

For Nasal Spray Form:

• Nasal irritation or dryness
  
• Sneezing
  
• Nosebleeds (epistaxis)
  
• Throat irritation or soreness
  
• Headache
  
  

More severe side effects of fluticasone use can include:

• Allergic reactions: Such as rash, itching, swelling of the face, lips, or throat, difficulty breathing
  
• Eye problems: Including glaucoma, cataracts, blurred vision
  
• Increased risk of infections: Due to the suppression of the immune system
  
• Adrenal insufficiency: Especially with long-term use or high doses
  
  

If you experience any severe side effects while using fluticasone, especially those that indicate an allergic reaction or serious eye problems, seek medical attention immediately.

Before using fluticasone, it's important to inform your healthcare provider about any existing medical conditions, allergies, or medications you are currently taking. This includes prescription drugs, over-the-counter medications, and dietary supplements, as they may interact with fluticasone.

Tell your provider if you are taking the following medications or supplements:

• Other corticosteroids
  
• Immunosuppressants
  
• Antifungal medications
  
• HIV/AIDS medications
  
• Beta-blockers
  
• Herbal supplements like St. John's wort or others
  
  

Additionally, mention any medical conditions you have, such as:

• Allergies, especially to corticosteroids
  
• Eye problems, including glaucoma or cataracts
  
• Infections, especially tuberculosis or herpes simplex in the eye
  
• Liver or kidney problems
  
• Diabetes
  
• Pregnancy, planning to become pregnant, or breastfeeding
  
  

Discuss with your healthcare provider any specific instructions or precautions related to your use of fluticasone.

For both inhalant and nasal spray forms of fluticasone:

• Follow the instructions provided with your medication regarding dosage and administration.
  
• Rinse your mouth with water after using inhalant fluticasone to reduce the risk of throat irritation or oral yeast infections.
  
• Use nasal spray fluticasone as directed, aiming away from the center of your nose and avoiding contact with your eyes.
  
• Clean the inhaler or nasal spray device regularly as instructed.
  
  

In case of an overdose of fluticasone, seek medical attention immediately. Symptoms may include severe throat irritation, worsening of side effects, or signs of adrenal insufficiency. If you suspect an overdose, contact the poison control helpline at 1-800-222-1222 or call emergency services.