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Methylprednisolone

Common Brand Names: Medrol

Drug Information

Medically reviewed by Jessica Swirble, PharmD
Last updated on April 18, 2025

Drug Information | Side Effects | Use & Dosage | Request an Online Prescription

Quick facts:

  • Brand Name: Medrol
  • Generic Name: Methylprednisolone
  • Uses: Treating inflammation, severe allergies, flare-ups of ongoing illnesses, and many other medical problems
  • Drug Class: Corticosteroid
  • Availability: Prescription only
  • Generic Status: Yes
  • Controlled Substance: No

What is methylprednisolone?

Methylprednisolone is a corticosteroid medication that is commonly prescribed to treat a variety of inflammatory conditions and immune system disorders.

What conditions does methylprednisolone treat?

Methylprednisolone is used to treat conditions such as:

  • Allergic reactions
  • Inflammation
  • Adrenal deficiency (low levels of corticosteroids in the body)
  • Multiple sclerosis
  • Asthma
  • Arthritis
  • Lupus
  • Ulcerative colitis (chronic inflammation of the bowels)

It may also be prescribed for other medical conditions as determined by your healthcare provider.

How does methylprednisolone work?

Methylprednisolone, a corticosteroid, is a synthesized version of naturally occurring hormones produced by the adrenal glands. These hormones play a crucial role in regulating various functions in the body. By inhibiting certain immune responses, methylprednisolone helps to prevent your immune system from overreacting to triggers, thereby blocking certain proteins that cause swelling and inflammation. This action can help alleviate uncomfortable symptoms and reduce the potentially harmful effects of inflammation.

How do I take methylprednisolone?

Methylprednisolone is available in the following forms:

  • Oral tablets
  • Injectable forms (Intravenous or intramuscular)

The dosage and frequency of use depend on the condition being treated, its severity, and how you respond to the medication.

Follow your healthcare provider's instructions regarding dosage and schedule. Do not exceed the prescribed dose or frequency of use without consulting your provider.

How long until I feel better?

Methylprednisolone is used to reduce inflammation and suppress the immune system in various conditions. The effects can be felt within a few days. However, how long it takes to feel better depends on the specific condition being treated.

Continue using methylprednisolone as prescribed, even if you start feeling better. Regular use according to your prescription is crucial for the management of symptoms.

Are there any other uses for methylprednisolone?

While methylprednisolone is primarily used for treating inflammation, severe allergies, and autoimmune disorders, healthcare providers may prescribe it off-label for other conditions that involve inflammation.

Discuss any alternative uses of methylprednisolone with your healthcare provider.

Dosage forms of methylprednisolone

Methylprednisolone is available in the following dosage forms:

  • Oral tablets
  • Injectable forms (such as intravenous or intramuscular)

Methylprednisolone is a prescription medication. You will need a valid prescription from a licensed healthcare provider to obtain this medication.

Side Effects and Precautions for Methylprednisolone


Drug Information | Side Effects | Use & Dosage | Request an Online Prescription

What are the side effects of methylprednisolone?

The use of methylprednisolone can lead to various side effects in some individuals.

Common mild side effects of methylprednisolone use include:

  • Increased appetite
  • Weight gain
  • Changes in where fat is located in your body
  • Mood changes (such as irritability or agitation)
  • Trouble sleeping (insomnia)
  • Acne or skin changes
  • Increased sweating
  • Headache
  • Dizziness
  • Nausea or stomach discomfort
  • Changes in menstrual periods

More severe side effects of methylprednisolone use can include:

  • Swelling
  • Low potassium levels
  • Rapid weight gain
  • Muscle pain in the arms, legs, or back
  • Cataracts or glaucoma (eye problems)
  • Vision problems
  • Seizures
  • Black or tarry stools
  • Coughing up blood
  • Vomit that looks like coffee grounds
  • Mental health changes (such as depression or anxiety)
  • Increases in blood pressure
  • Increase in blood sugar levels

If you experience any severe or concerning side effects while taking methylprednisolone, contact your healthcare provider right away.

What should I tell my healthcare provider before using methylprednisolone?

Inform your healthcare provider about any existing medical conditions, allergies, or other medications you are taking before starting treatment with prednisone. This includes prescription drugs, over-the-counter medications, and dietary supplements, as they may interact with methylprednisolone.

Tell your provider if you are taking these medications or have these conditions:

  • Other corticosteroids or immunosuppressants
  • Nonsteroidal anti-inflammatory drugs (NSAIDs)
  • Anticoagulants or antiplatelet drugs
  • Antiarrhythmic medications
  • Blood pressure medications
  • Antibiotics or antifungals
  • HIV/AIDS medications
  • Tuberculosis medications
  • Hepatitis medications

You should also mention medical conditions such as:

  • History of mental health disorders
  • Recent eye infections, glaucoma, or cataracts
  • Liver or kidney disease
  • Intestinal disease
  • Thyroid disease
  • Myasthenia gravis
  • Multiple sclerosis
  • High blood pressure
  • Seizures
  • Diabetes
  • Infections or recent vaccinations
  • Osteoporosis
  • Stomach ulcers

If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of using prednisone with your healthcare provider.

Are there any other special instructions I should follow?

Take methylprednisolone exactly as prescribed by your healthcare provider. Do not exceed the recommended dose or duration of treatment.

Methylprednisolone can be taken with or without food, but taking it with food may help reduce stomach upset. It's important to complete the full course of treatment, even if you feel better, to ensure the medication's effectiveness in managing your condition.

What should I do in case of an overdose?

In case of a methylprednisolone overdose, seek medical attention immediately. Symptoms of overdose may include severe nausea, vomiting, altered mental status, or seizures. If you suspect an overdose, contact the poison control helpline at 1-800-222-1222 or call emergency services.

Proper Use & Dosage Information for Methylprednisolone


Drug Information | Side Effects | Use & Dosage | Request an Online Prescription

What is the typical starting dose for methylprednisolone?

Methylprednisolone is available in the following forms:

  • Oral tablets
  • Injectable forms (Intravenous or intramuscular)

The typical starting dose of methylprednisolone varies depending on the condition being treated, the severity of symptoms, and individual patient factors. It is crucial to follow your healthcare provider's instructions regarding dosage and administration.

For inflammatory or autoimmune conditions:

  • Adults: Doses may range from 4 mg to 48 mg daily, depending on the specific condition.
  • Children: Dosage is based on body weight and must be determined by your doctor.

The dosage may be adjusted based on the response and tolerance to the medication. Your healthcare provider will determine the most appropriate dose based on your medical history and your response to the medication.

Methylprednisolone should be taken as prescribed by your healthcare provider. Do not exceed the recommended dose or duration of treatment without consulting your provider.

If you have any questions about your dosage or need adjustments, contact your healthcare provider for guidance. If you want to talk to a provider right away, consider scheduling an online doctor appointment through a telehealth platform like Sesame.

What should I do if I miss a dose of methylprednisolone?

If you miss a dose of methylprednisolone, take it as soon as you remember unless it is close to the time for your next scheduled dose. In that case, skip the missed dose and continue your regular dosing schedule. Do not double the dose to make up for a missed one.

Take methylprednisolone around the same time every day to maintain an even level of medication in your body.

What should I do if I'm feeling better while taking methylprednisolone?

Continue taking methylprednisolone as prescribed by your healthcare provider, even if you start feeling better. It's important to keep taking the medication as directed to manage your condition effectively.

If you have any concerns or questions about your medication, discuss them with your healthcare provider for medical advice and recommendations.

How should I store methylprednisolone?

Store methylprednisolone according to the instructions provided by your healthcare provider or pharmacist. Keep it at room temperature, away from light and moisture. Ensure the container is tightly closed and out of reach of children.

Do not use expired medication or medications that appear damaged or discolored. If you have any questions about storage, consult your healthcare provider or pharmacist for guidance.

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