Medically reviewed by Jessica Swirble, PharmD
Last updated on April 21, 2025
Drug Information | Side Effects | Use & Dosage | Request an Online Prescription
Quick facts:
Topical metronidazole is an antibiotic medication used to treat specific skin conditions, such as rosacea. It belongs to a class of antibiotics known as nitroimidazoles.
Topical metronidazole is prescribed to treat various skin conditions, including:
Topical metronidazole is not effective against viral or fungal infections.
Topical metronidazole works by disrupting the DNA and cellular structure of bacteria, leading to their death and reducing inflammation.
It's important to note that topical metronidazole should not be used for viral or fungal infections.
Topical metronidazole is available in various forms, including creams, gels, and lotions. The dosage and duration of treatment will depend on the type and severity of the condition, as well as your medical condition and response to the medication.
Complete the full course of topical metronidazole as prescribed, even if your symptoms improve before the treatment is finished. Stopping the medication early can cause the infection to reoccur.
Consult your healthcare provider for specific instructions on how to use topical metronidazole properly.
The time it takes to experience symptom relief while using topical metronidazole can vary depending on the type and severity of the condition. Some individuals may notice improvement within a few days, while others may require a longer duration of treatment.
Continue using topical metronidazole as directed by your healthcare provider and complete the full prescribed course to ensure effective treatment.
In addition to its primary use in treating rosacea, topical metronidazole may have off-label uses or be part of combination therapies for certain conditions. Off-label uses may include:
Discuss any alternative uses of topical metronidazole with your healthcare provider. v
Topical metronidazole is available in various dosage forms, including:
Generic versions of topical metronidazole are available under various brand names.
Topical metronidazole is a prescription medication. You will need a valid prescription from a licensed healthcare provider to obtain this drug.
| Side Effects | Use & Dosage | Request an Online Prescription
The use of topical metronidazole has been shown to cause side effects in some patients.
Common mild side effects of topical metronidazole use include:
More severe side effects include:
Seek medical attention immediately if you experience any severe symptoms while using topical metronidazole. If you experience mild side effects that become severe or do not go away after a few days, speak to a healthcare provider right away.
Tell your healthcare provider about any existing medical conditions, allergies, or other medications you are taking before starting treatment with topical metronidazole. This includes prescription drugs, over-the-counter medications, and dietary supplements, as they may interact with this drug.
Tell your provider if you are taking these medications or supplements:
You should also mention medical conditions such as:
If you are pregnant, planning to become pregnant, or breastfeeding, consult your healthcare provider before using topical metronidazole to assess potential risks and benefits.
Your healthcare provider will provide specific instructions regarding the use of topical metronidazole with food, beverages, and other medications. It's essential to follow their guidance to ensure the effectiveness of the treatment and minimize the risk of side effects.
The symptoms of a topical metronidazole overdose include:
If you experience any of these symptoms, call the poison control helpline at 1-800-222-1222. If an individual has collapsed, is having seizures, or is unresponsive, call 9-1-1 immediately.
| Side Effects | Use & Dosage | Request an Online Prescription
Topical metronidazole is available in the following forms:
The typical starting dose of topical metronidazole can vary depending on the condition being treated, the severity of the symptoms, and individual patient factors. It is crucial to follow your healthcare provider's instructions regarding dosage and administration carefully.
For rosacea:
For bacterial vaginosis (vaginal gel):
Your healthcare provider will assess your medical history, current medications, and your condition to determine the most appropriate starting dose and duration of treatment for you.
Topical metronidazole should be used exactly as prescribed by your healthcare provider. Do not exceed the recommended dose or make changes to your medication regimen without consulting your provider.
If you have any questions about your dosage, contact your healthcare provider. If you want to talk to a provider right away, book an online doctor appointment on Sesame to discuss your concerns.
If you miss a dose of topical metronidazole, apply it as soon as you remember. If it's almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not apply a double dose to make up for a missed one.
Do not discontinue or alter your metronidazole dosage without consulting with your healthcare provider. Follow your healthcare provider's instructions regarding dosing and other recommendations for taking metronidazole. It's important to complete the full course of treatment to ensure the infection is fully treated and to prevent resistance.
Store metronidazole as directed by your healthcare provider or pharmacist. Proper storage is essential to maintain the medication's effectiveness. Metronidazole should be stored at room temperature, away from excessive heat, light, and moisture.
Keep the medication out of the reach of children and ensure that the container is tightly closed.