As with all prescription medications, inform your prescribing doctor about any medical conditions you have and any medications and supplements you are currently taking before starting treatment with nabumetone. This drug can interact with other medicines and substances, leading to potentially serious side effects.
You should tell your provider if you are taking:
Other NSAIDs: Concurrent use of multiple NSAIDs, including ibuprofen, aspirin, or other similar drugs, can increase the risk of gastrointestinal bleeding and ulcers.
Anticoagulants (Blood Thinners): Combining nabumetone with anticoagulants like warfarin may increase the risk of bleeding due to the potential for platelet dysfunction.
Corticosteroids: The risk of gastrointestinal bleeding and ulcers may increase when taking corticosteroids alongside nabumetone.
Antiplatelet Drugs: Using antiplatelet medications like clopidogrel along with nabumetone can raise the risk of bleeding.
SSRIs and SNRIs: Selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) can increase the risk of bleeding when taken with nabumetone.
ACE Inhibitors and ARBs: Angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs) may reduce the antihypertensive effects of these medications when combined with nabumetone.
Diuretics: Diuretics, such as loop diuretics or thiazides, can reduce kidney function, potentially leading to kidney problems when used with nabumetone.
Methotrexate: The combination of nabumetone and methotrexate can increase the risk of methotrexate toxicity, affecting the bone marrow, liver, and gastrointestinal tract.
Lithium: Nabumetone can increase lithium levels in the blood, potentially leading to lithium toxicity.
Cyclosporine and Tacrolimus: Taking nabumetone with immunosuppressants like cyclosporine and tacrolimus can increase the risk of kidney damage.
This is not a complete list of all drugs that interact with nabumetone. Make a comprehensive list of all medicines and supplements that you take before starting treatment with this drug.
You should also tell your healthcare provider about any medical conditions you manage. Nabumetone can increase your risk of heart attack or stroke. Nabumetone can also increase your risk of stomach bleeding or ulcers. Caution should be advised in those with asthma.
Avoid alcohol use with this medication.
Let your doctor know if you are pregnant or plan on becoming pregnant before starting treatment with nabumetone. If you become pregnant while taking this medication, stop taking it and inform your healthcare provider immediately.