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Common Brand Names: Protonix

Side Effects & Precautions

Medically reviewed by Jessica Swirble, PharmD
Last updated on 5/14/2024

Drug Information | Side Effects | Use & Dosage | Request a Prescription

What are the side effects of pantoprazole?

The use of pantoprazole can lead to various side effects in some individuals.

Common mild side effects of pantoprazole use include:

  • Headache
  • Diarrhea
  • Nausea
  • Abdominal pain
  • Vomiting
  • Gas
  • Dizziness
  • Joint pain

More severe side effects of pantoprazole use can include:

  • Severe stomach pain
  • Watery and bloody diarrhea
  • Changes in heartbeat
  • Lightheadedness
  • Dizziness
  • Seizures
  • Blood in urine
  • Increased or decreased urination
  • Muscle cramps
  • Muscle spasms
  • Tremors
  • Skin rash on the face or cheeks

If you experience any severe or concerning side effects while taking pantoprazole, contact your healthcare provider right away.

What should I tell my healthcare provider before using pantoprazole?

Tell your healthcare provider about any existing medical conditions, allergies, or other medications you are taking before starting treatment with pantoprazole. This includes prescription drugs, over-the-counter medications, and dietary supplements, as they may interact with pantoprazole.

Tell your provider if you are taking these medications or supplements:

  • HIV medications
  • Chemotherapy medications
  • Clopidogrel
  • Methotrexate
  • Ketoconazole
  • Posaconazole
  • Cefuroxime
  • St. John’s-Wort

You should also mention medical conditions such as:

  • Liver disease
  • Osteoporosis or low bone mineral density
  • Low potassium, calcium, or magnesium levels
  • Lupus
  • Vitamin B12 deficiency

If you are pregnant, planning to become pregnant, or breastfeeding, consult your healthcare provider before using pantoprazole to assess potential risks and benefits.

Are there any other special instructions I should follow?

Take pantoprazole exactly as prescribed by your healthcare provider. Do not exceed the recommended dose or duration of treatment.

Pantoprazole can impair your ability to absorb certain vitamins and minerals. Be aware of any symptoms of deficiencies, such as muscle cramps or irregular heartbeat, which could suggest low magnesium levels.

Take pantoprazole at the same time every day, usually in the morning before eating. Pantoprazole should be taken on an empty stomach about 30 to 60 minutes before meals.

What should I do in case of an overdose?

In case of a pantoprazole overdose, seek medical attention immediately. Symptoms of overdose may include confusion, dizziness, blurred vision, dry mouth, flushing, headache, nausea, and sweating. If you suspect an overdose, contact the poison control helpline at 1-800-222-1222 or call emergency services.