Medically reviewed by Jessica Swirble, PharmD
Last updated on April 2, 2025
Drug Information | Side Effects | Use & Dosage | Request an Online Prescription
Spironolactone is a medication classified as an aldosterone antagonist. It is also classified as a potassium-sparing diuretic. It is used to treat conditions such as high blood pressure (hypertension), heart failure, edema (fluid retention), and certain hormonal imbalances.
Spironolactone is used to treat conditions such as:
It may also be prescribed for other medical conditions as determined by your healthcare provider.
Spironolactone works by blocking the effects of aldosterone, a hormone that regulates salt and water balance in the body. By blocking aldosterone, spironolactone helps the kidneys remove excess fluid and sodium from the body while holding on to potassium.
Spironolactone is usually taken orally with or without food, as directed by your healthcare provider. It should be taken around the same time every day and should either always be taken with food or always without. The dosage and frequency of spironolactone depend on your condition and response to treatment.
Follow the prescribed dosage and schedule strictly. Do not stop taking spironolactone suddenly without consulting your healthcare provider, as it may cause a sudden increase in blood pressure or fluid retention.
The time it takes to feel the full effects of spironolactone can vary depending on the condition being treated. Some people may notice improvement in symptoms such as fluid retention or high blood pressure within a few days to weeks, while others may require longer-term treatment for chronic conditions.
Continue taking spironolactone as prescribed even if you do not immediately feel better. Talk to your healthcare provider if you have any concerns about your treatment.
While spironolactone is primarily used for hypertension, heart failure, and edema, healthcare providers may sometimes prescribe it off-label for other conditions, such as:
Discuss any alternative uses of spironolactone with your healthcare provider.
Spironolactone is available in the following dosage forms:
Generic versions of spironolactone are available under various brand names.
Spironolactone is a prescription medication. You will need a valid prescription from a licensed healthcare provider to obtain this medication.
The use of spironolactone can lead to various side effects in some individuals.
Common mild side effects of spironolactone use include:
More severe side effects of spironolactone use can include:
If you experience any severe side effects while taking spironolactone, seek immediate medical attention.
Inform your healthcare provider about any existing medical conditions, allergies, or other medications you are taking before starting treatment with spironolactone. This includes prescription drugs, over-the-counter medications, and dietary supplements, as they may interact with spironolactone.
Tell your provider if you are taking these medications or supplements:
Mention medical conditions such as:
If you are pregnant, planning to become pregnant, or breastfeeding, consult your healthcare provider before using spironolactone to assess potential risks and benefits.
Take spironolactone exactly as prescribed by your healthcare provider. Do not increase or decrease the dosage without consulting them.
Spironolactone may be prescribed along with daily exercise and a reduced-sodium diet. Avoid taking potassium-based salt substitutes while taking spironolactone.
It's important to monitor your potassium levels regularly while taking spironolactone, especially if you have conditions that can affect potassium balance. Avoid excessive consumption of potassium-rich foods or supplements while on spironolactone, unless advised otherwise by your healthcare provider. This may include bananas, prunes, raisins, apricots, and orange juice.
If you experience symptoms such as excessive thirst, confusion, weakness, irregular heartbeat, or muscle cramps, contact your healthcare provider promptly as they may indicate electrolyte imbalances.
In case of a spironolactone overdose, seek immediate medical attention. Symptoms may include confusion, dizziness, drowsiness, nausea, vomiting, irregular heartbeat, or fainting. If you suspect an overdose, contact the poison control helpline at 1-800-222-1222 or call emergency services.
Spironolactone is available in the following forms:
The typical starting dose of spironolactone varies depending on the condition being treated, the severity of symptoms, and individual patient factors. It is important to follow your healthcare provider's instructions regarding dosage and administration.
For conditions like heart failure, hypertension, or certain hormonal disorders, the typical starting doses may be:
Your healthcare provider will determine the most appropriate dose based on your medical history, current medications, and response to treatment.
Spironolactone should be taken exactly as prescribed by your healthcare provider. Do not exceed the recommended dose or duration of treatment without consulting your provider.
If you have any questions about your dosage or need adjustments, contact your healthcare provider for guidance. If you need immediate medical advice or assistance, consider scheduling an online doctor appointment through a platform like Sesame.
If you miss a dose of spironolactone, take it as soon as you remember. If it's almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Continue taking spironolactone as prescribed by your healthcare provider, even if you start feeling better. Abruptly stopping spironolactone can lead to the worsening of your condition. Follow your provider's instructions regarding the duration of treatment.
Store spironolactone according to the instructions provided by your healthcare provider or pharmacist. It should be kept at room temperature, away from moisture, heat, and light. Ensure the container is tightly closed and keep the medication out of the reach of children.