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Sulfamethoxazole-trimethoprim
Common Brand Names: Bactrim, Septra, Sulfatrim
Side Effects & Precautions
Medically reviewed by Jessica Swirble, PharmD
Last updated on 4/2/2024
Drug Information | Side Effects | Use & Dosage| Request a Prescription
The use of sulfamethoxazole-trimethoprim has been shown to cause side effects in some patients.
Common mild side effects of sulfamethoxazole-trimethoprim use include:
- Nausea
- Vomiting
- Diarrhea
- Loss of appetite
- Skin rash
- Itching
- Headache
- Dizziness
- Fatigue/ tiredness
More severe side effects include:
- Severe skin reactions
- Severe stomach pain
- Joint pain
- Liver damage or jaundice
- Blood disorders
- Irregular heartbeat
- Kidney problems (such as acute kidney injury)
- Severe allergic reactions (such as swelling, difficulty breathing, hives)
Seek medical attention immediately if you experience any severe symptoms while taking sulfamethoxazole-trimethoprim. If you experience mild side effects that become severe or do not go away after a few days, speak to a healthcare provider right away.
Tell your healthcare provider about any existing medical conditions, allergies, or other medications you are taking before starting treatment with sulfamethoxazole-trimethoprim. This includes prescription drugs, over-the-counter medications, and dietary supplements, as they may interact with this drug.
Tell your provider if you are taking these medications or supplements:
- ACE inhibitors (e.g., benazepril, captopril, enalapril)
- Angiotensin receptor blockers (e.g., losartan, valsartan)
- Diuretics ('water pills')
- Methotrexate
- Warfarin
- Phenytoin
- Sulfonylureas (e.g., glipizide, glyburide)
- Digoxin
- Cyclosporin
- Cannabis
You should also mention medical conditions such as:
- Kidney disease
- Liver disease
- Blood disorders
- Allergies to sulfa drugs or trimethoprim
- Asthma or other respiratory conditions
- HIV/ AIDS
- Alcoholism
- Thyroid disorders
- Electrolyte imbalances
If you are pregnant, planning to become pregnant, or breastfeeding, consult your healthcare provider before using sulfamethoxazole-trimethoprim to assess potential risks and benefits.
You can follow your regular diet while taking sulfamethoxazole-trimethoprim. Talk to your healthcare provider about the use of this drug with food, beverages, alcohol, and tobacco.
Your healthcare provider will provide specific instructions regarding the use of sulfamethoxazole-trimethoprim with food, beverages, and other medications. It's essential to follow their guidance to ensure the effectiveness of the treatment and minimize the risk of side effects.
The symptoms of a sulfamethoxazole-trimethoprim overdose include:
- Nausea
- Vomiting
- Dizziness
- Confusion
- Yellowing of the skin or eyes (jaundice)
- Dark urine
- Difficulty breathing
If you experience any of these symptoms, call the poison control helpline at 1-800-222-1222. If an individual has collapsed, is having seizures, or is unresponsive, call 9-1-1 immediately.