Medically reviewed by Jessica Swirble, PharmD
Last updated on April 17, 2025
Drug Information | Side Effects | Use & Dosage | Request an Online Prescription
Tizanidine is an alpha-2 adrenergic agonist used to manage involuntary muscle spasms and stiffness, commonly associated with neurological disorders and spinal cord injuries. It relaxes tightened muscles, reducing pain and discomfort.
Tizanidine is primarily prescribed for conditions such as:
It may also be used for other muscle spasticity-related conditions as determined by your healthcare provider.
Tizanidine works by stimulating alpha-2 adrenergic receptors in the central nervous system. This action blocks nerve impulses that cause tightened muscles, thereby reducing the severity of muscle spasms and allowing for easier movement.
Tizanidine is typically taken orally in tablet form up to three times a day, depending on the severity of the condition and the doctor's prescription. It should be taken consistently either with or without food, unless directed otherwise by your healthcare provider.
Always follow your healthcare provider’s instructions regarding dosage and schedule. Do not alter the prescribed dose or treatment duration without consulting your provider.
The effectiveness of tizanidine and the time it takes to notice improvement can vary among individuals. Some may experience relief from muscle spasms and reduced stiffness within hours of their first dose, while others might need longer treatment to observe benefits.
Continue taking tizanidine as directed even if symptoms improve. Stopping the medication abruptly can lead to a return of symptoms.
While tizanidine is mainly used for managing muscle spasticity, healthcare providers may prescribe it off-label for other muscle-related conditions, such as:
Consult your healthcare provider for more information on the potential uses of tizanidine.
Tizanidine is available in the following dosage forms:
Generic versions of tizanidine are available, providing cost-effective treatment options.
Tizanidine is a prescription medication. You will need a valid prescription from a licensed healthcare provider to obtain this medication.
The use of tizanidine can lead to various side effects in some individuals.
Common mild side effects of tizanidine use include:
More severe side effects of tizanidine use can include:
If you experience any severe or concerning side effects while taking tizanidine, contact your healthcare provider promptly.
Tell your healthcare provider about any existing medical conditions, allergies, or other medications you are taking before starting treatment with tizanidine. This includes prescription drugs, over-the-counter medications, and dietary supplements, as they may interact with tizanidine.
Tell your provider if you are taking these medications or supplements:
You should also mention medical conditions such as:
If you are pregnant, planning to become pregnant, or breastfeeding, consult your healthcare provider before using tizanidine to assess potential risks and benefits.
Take tizanidine exactly as prescribed by your healthcare provider. The dose may need to be adjusted based on your response to the medication and any side effects you experience.
Tizanidine should be consistently taken with food or consistently without food.
Avoid alcohol while taking tizanidine, as it can increase the sedative effects of the medication and increase the risk of side effects like dizziness or drowsiness.
Do not abruptly stop taking tizanidine, as it can cause severe withdrawal symptoms. Your healthcare provider will gradually decrease your dosage.
Store tizanidine at room temperature, away from moisture and heat. Keep it out of reach of children.
In case of a tizanidine overdose, seek medical attention immediately. Symptoms of overdose may include extreme drowsiness, confusion, slowed heart rate, shallow breathing, fainting, or coma. If you suspect an overdose, contact the poison control helpline at 1-800-222-1222 or call emergency services.
Tizanidine is available in the following forms:
The typical starting dose of tizanidine varies depending on the condition being treated, the severity of symptoms, and individual patient factors. It is important to follow your healthcare provider's instructions regarding dosage and administration.
For muscle spasticity associated with multiple sclerosis, spinal cord injury, or other neurological disorders, the typical starting doses may be:
Your healthcare provider will determine the most appropriate dose based on your medical history, current medications, and response to treatment.
Tizanidine should be taken exactly as prescribed by your healthcare provider. Do not exceed the recommended dose or duration of treatment without consulting your provider.
If you have any questions about your dosage or how to take this medication, contact your healthcare provider or pharmacist. If you want to talk to a provider right away, consider booking an online doctor appointment on Sesame to discuss your concerns.
If you miss a dose of tizanidine, take it as soon as you remember unless it is close to the time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.
Maintain a consistent dosing schedule to ensure the effectiveness of tizanidine in managing your muscle spasticity.
Continue taking tizanidine as prescribed by your healthcare provider, even if you start feeling better. Do not stop the medication abruptly without consulting your provider, as it may lead to a recurrence of symptoms or other complications.
If you have any concerns or questions about your medication, discuss them with your healthcare provider for personalized guidance and recommendations.
Store tizanidine according to the instructions provided by your healthcare provider or pharmacist. Keep it at room temperature, away from moisture, heat, and light. Ensure the container is tightly closed and out of reach of children.
Do not use expired medication or medications that appear damaged or discolored. If you have any questions about storage, consult your healthcare provider or pharmacist for guidance.