Medically reviewed by Jessica Swirble, PharmD
Last updated on March 28, 2025
Drug Information | Side Effects | Use & Dosage | Request an Online Prescription
Trazodone is a medication primarily used to treat major depressive disorder (MDD) and insomnia. It belongs to the class of antidepressants known as serotonin antagonists and reuptake inhibitors (SARIs). Trazodone works by affecting serotonin levels in the brain, helping to improve mood and sleep patterns.
Trazodone is commonly prescribed to manage symptoms of depression—also known as major depressive disorder (MDD).
Trazodone works by blocking the reuptake of serotonin in the brain. This action helps regulate mood and emotions, contributing to its antidepressant effects. Additionally, trazodone can help insomnia by promoting relaxation and sleep.
It's important to note that trazodone should be taken as prescribed by your healthcare provider and not stopped abruptly, as discontinuation without proper guidance can lead to withdrawal symptoms.
Trazodone is typically taken orally in tablet form, with or without food. The dosage and frequency of administration will be determined by your healthcare provider based on your medical condition and response to treatment. It's crucial to follow the prescribed dosage and instructions carefully.
For insomnia, trazodone is usually taken shortly before bedtime to aid in sleep initiation and maintenance.
Consult your healthcare provider for specific instructions on how to take trazodone properly.
The effects of trazodone on mood and sleep patterns may vary from person to person. Some individuals may experience improvements in depressive symptoms within a few weeks of starting treatment, while others may require several weeks for noticeable changes.
Similarly, trazodone's effectiveness in treating insomnia may be observed shortly after starting treatment, but noticeable results may take time. Consistent use of trazodone as directed by your healthcare provider is essential for achieving desired outcomes.
In addition to treating MDD, trazodone may have other off-label uses, including:
Insomnia: Trazodone has sedative properties and may be used to treat insomnia in some patients.
Anxiety disorders: Trazodone may be prescribed to manage symptoms of anxiety disorders, such as generalized anxiety disorder (GAD) or panic disorder.
Schizophrenia: Trazodone may be prescribed to treat symptoms of schizophrenia.
Post-traumatic stress disorder (PTSD): Trazodone might be used as part of a comprehensive treatment plan for individuals with PTSD, helping alleviate sleep disturbances and certain anxiety symptoms.
Fibromyalgia: Trazodone may be considered in managing sleep difficulties and associated symptoms in individuals with fibromyalgia.
Discuss any alternative uses of trazodone with your healthcare provider.
Trazodone is available as an oral tablet in various strengths, including 50mg, 100mg, 150mg, and 300mg. The dosage prescribed will depend on the specific condition being treated and individual factors.
Generic versions of trazodone are available under different brand names.
Trazodone is a prescription medication and a valid prescription from a licensed healthcare provider is required to obtain this drug.
The use of trazodone has been shown to cause side effects in some patients.
Common mild side effects of trazodone use include:
More severe side effects include:
Seek medical attention immediately if you experience any severe symptoms while taking trazodone. If you experience mild side effects that become severe or do not go away after a few days, speak to a healthcare provider right away.
Tell your healthcare provider about any existing medical conditions, allergies, or other medications you are taking before starting treatment with trazodone. This includes prescription drugs, over-the-counter medications, and dietary supplements, as they may interact with this drug.
Tell your provider if you are taking these medications or supplements:
You should also mention medical conditions such as:
If you are pregnant, planning to become pregnant, or breastfeeding, consult your healthcare provider before using trazodone to assess potential risks and benefits.
Talk to your healthcare provider about the use of this drug with food, beverages, alcohol, and tobacco.
Avoid consuming alcohol while taking trazodone, as it can increase drowsiness and impair cognitive function.
Do not drink grapefruit juice or consume grapefruit while using trazodone.
Inform healthcare providers performing surgeries or procedures that you are taking trazodone, as it may interact with anesthesia and other medications used during these interventions.
Be cautious when driving or operating machinery, as trazodone can cause drowsiness and affect alertness.
Attend regular follow-up appointments with your healthcare provider to monitor treatment progress, adjust dosages if needed, and address any concerns or side effects.
Your healthcare provider will provide specific instructions regarding the use of trazodone with food, beverages, and other medications. It's essential to follow their guidance to ensure the effectiveness of the treatment and minimize the risk of side effects.
The symptoms of a trazodone overdose include:
If you experience any of these symptoms, call the poison control helpline at 1-800-222-1222. If an individual has collapsed, is having seizures, or is unresponsive, call 9-1-1 immediately.
Trazodone is available in various forms:
The typical starting dose of trazodone can vary depending on the specific condition being treated, the patient's age, medical history, and other individual factors. It is essential to follow your healthcare provider's instructions regarding dosage and administration carefully.
For the treatment of depression in adults, the typical starting doses may be:
For the treatment of insomnia, the typical starting dose may be:
Your healthcare provider will assess your medical history, current medications, and the nature of your condition to determine the most appropriate starting dose for you.
Trazodone should be taken exactly as prescribed by your healthcare provider. Do not exceed the recommended dose or make changes to your medication regimen without consulting your provider.
If you have any questions about your dosage, contact your healthcare provider. If you want to talk to a provider right away, book an online doctor appointment on Sesame to discuss your concerns.
If you miss a dose, take it as soon as you remember it. If it's almost time for another dose of trazodone, skip the missed dose and take your next dose as scheduled. Do not take or apply a double dose of trazodone.
Do not stop or alter your trazodone dosage without consulting your healthcare provider. Abruptly discontinuing trazodone can lead to withdrawal symptoms and recurrence of depressive symptoms or insomnia. Follow-up appointments with your healthcare provider are essential for monitoring your progress and making any necessary dosage adjustments.
Store trazodone as directed by your healthcare provider or pharmacist. Proper storage is essential to maintain the medication's effectiveness. Trazodone should be stored at room temperature, away from excessive heat, light, and moisture.
Keep the medication out of the reach of children and ensure that the container is tightly closed.