Sesame Logo
5 min read

Do Prescription Medications Expire? Here's What You Need to Know.

Published on April 12, 2022
5 min read
Allison Edwards, MD, Medical Director
Medically reviewed by
Sesame Staff
Written by

Did you know that each year 600+ million prescriptions go unused?

Open your medicine cabinet and chances are, you’ll find some expired medication. These leftover pills aren’t just a little old. They can actually be dangerous.

Friday, April 15 is National Clean Out Your Medicine Cabinet Day - a reminder to open your cabinet and get rid of unused medications. We talked to Sesame’s Medical Director Dr. Allison Edwards about old prescriptions, the potential hazards of expired pills and more.

Question: For medications, should the expiration date be strictly followed, or does the effectiveness of the medication just weaken after the expiration date?

Dr. Edwards: Expiration dates on medicines have been mandated for decades and serve as the date at which the medication is guaranteed – by its manufacturer – to have its full effect. There have been interesting studies done over the years that show that even years out – sometimes decades! – medicines retain a significant amount of their potency. This is not true of temperature-sensitive medicines, like insulin, but the average shelf-stable medicine, whether over-the-counter or prescription, is likely potent beyond its expiration date so long as it hasn’t been subjected to wild fluctuations in temperature or humidity.

Question: Does the expiration matter more if it’s a prescription vs. an over the counter medication?

Dr. Edwards: Expiration dates are similarly reliable – or unreliable! – for both prescription and over the counter medicines.

Question: At what point should over the counter medications be disposed of?

Dr. Edwards: You can likely keep a medication for a bit beyond its expiration date, but you have to know that anything kept beyond its expiration date may slowly be losing potency as it ages. So long as you keep your medicines in a cool, dry place, though, they should stay potent for quite some time. That said, things that are liquid or cream – or items that must be refrigerated – should probably adhere to expiration dates more closely.

Question: What’s the best way to dispose of expired medications?

Dr. Edwards: The DEA hosts a drug take back twice a year, which is a great time to safely dispose of any medications you have on hand, even controlled medications! The next one is on April 30th. The EPA also has an outline of the best ways to dispose of drugs here

Related posts

PregnancyJuly 9, 2024
When Do You Ovulate? Key Signs and Tracking Tips

Understanding ovulation and when it happens is key to planning or preventing pregnancy. Read on to learn how you can better estimate your fertile window and time of ovulation.

Read moreChevron Right Icon
HealthcareDecember 21, 2022
Children's Medicine Shortage: What You Need to Know

A children's medicine shortage is hitting stores just as flu season starts. Hear from Sesame's Medical Director, Allison Edwards, about steps you can take to protect your child.

Read moreChevron Right Icon
HealthcareDecember 6, 2023
How to Spend Your FSA Funds

To help you get the most out of your healthcare plan, we’ve compiled a list of 15 helpful, healthy ways to use those last bits of FSA funds.

Read moreChevron Right Icon
Weight LossAugust 19, 2025
The Semaglutide Shortage Is Ending: What’s Next For Compounded Drugs?

The FDA ended the semaglutide shortage on Feb 21, 2025. Learn key deadlines for compounded semaglutide, GLP-1 alternatives and more.

Read moreChevron Right Icon
NauseaSeptember 11, 2024
Fastest Acting Nausea Medications: OTC & Prescription

Nausea can make you feel miserable and keep you from daily activities. Fortunately, there are lots of medications that can provide nausea relief.

Read moreChevron Right Icon
PainJuly 1, 2025
Muscle Relaxers: Best Over-The-Counter and Rx Options

Learn about the best over-the-counter muscle relaxers and prescription muscle relaxers. Find out what the differences are and what might work best for you.

Read moreChevron Right Icon
Woman spraying SPF sunscreen on shoulders
SkinSeptember 17, 2025
SPF 30 vs 50: Is there a real difference in strength?

Is there really a difference between SPF 30 and SPF 50? And how can you get the most protection out of your sunscreen? Read on to learn more about SPF strength differences and how to protect your skin from the sun’s harmful rays.

Read moreChevron Right Icon
MedicationAugust 13, 2024
What is a Compounding Pharmacy? Questions & Answers

In this article, we’ll investigate the differences between types of pharmacies and what role compounded medications play in our national healthcare system.

Read moreChevron Right Icon
MedicationApril 29, 2024
Can You Pick Up a Prescription for Someone Else?

There are a number of reasons why you might need someone else to pick up your prescription for you. It’s possible to have someone get your medication from a pharmacy. Here’s what you need to know about having someone else pick up a prescription for you!

Read moreChevron Right Icon
Join our mailing list for exclusive promos, curated health content & more.
FacebookXLinkedIn
© 2025 Sesame, Inc. All rights reserved.