Mild side effects have been reported from acamprosate use. Talk to your doctor if these symptoms become severe or do not go away after a few days.
Mild side effects reported from acamprosate use include:
- Diarrhea
- Gas
- Loss of appetite
- Dry mouth
- Dizziness
- Nausea
- Anxiety
- Insomnia
- Sweating
In addition to these physical side effects, some people taking acamprosate may experience psychological side effects such as agitation, confusion, or depression. Other possible side effects could include increased heart rate or blood pressure and chest pain or tightness. While these symptoms are usually mild and short-lived they may be more pronounced in certain individuals depending on their health status or other medications being taken in conjunction with acamprosate. If any of these side effects occur it is important to contact a doctor for medical advice as soon as possible.
More serious side effects of acamprosate use include:
- Feelings of depression or sadness
- Suicidal thoughts
- Burning, tingling, or numbness in the hands, feet, arms, or legs
- Rash
If you begin to feel chest tightness or experience a rash, seek medical attention right away. These are signs of a potentially life-threatening allergic reaction.
Acamprosate has been shown to alter mood in sudden and unexpected ways. If you begin to experience feelings of sadness, isolation, depression, or suicidal thoughts, talk to a health care provider right away.
Tell your doctor about any prescription drugs or supplements you are taking before starting treatment with acamprosate. Let your doctor know if you are currently taking other drugs for alcohol use disorder (such as naltrexone or disulfiram). Additionally, talk to your doctor about any medical conditions you are managing before starting treatment.
Acamprosate may affect your thinking and decision-making. Do not operate heavy machinery or drive a car until you have tried the medication and learned how it does or does not affect you.
Finally, let your doctor know if you are pregnant or plan on becoming pregnant before starting treatment with acamprosate. If you become pregnant while taking acamprosate, inform your health care provider immediately. Do not take acamprosate if you are currently breastfeeding.