Medically reviewed by Jessica Swirble, PharmD
Last updated on April 18, 2025
Drug Information | Side Effects | Use & Dosage | Request an Online Prescription
Amitriptyline is a prescription medication used to treat major depressive disorder (depression). It is classified as a tricyclic antidepressant medication, which increases serotonin levels in the brain.
Amitriptyline is prescribed to treat major depressive disorder (depression).
Amitriptyline is often prescribed in conjunction with other forms of medication to treat anxiety or depression related to anxiety. It is also commonly prescribed along with other forms of therapy, like psychotherapy (‘talk therapy’).
Amitriptyline belongs to a class of medicines known as tricyclic antidepressants.
Tricyclic antidepressants work by increasing the amount of serotonin in your brain. Your brain naturally produces two neurotransmitters called serotonin and norepinephrine, which can help you stay focused, emotionally stable, happier, and calmer. In patients with major depressive disorder, it is thought that serotonin levels are low, which leads to depression symptoms.
Tricyclic antidepressants block the absorption of serotonin and norepinephrine, which leads to a build-up of these neurotransmitters. The increased concentrations of norepinephrine and serotonin help reduce depression symptoms.
Amitriptyline is available as an oral tablet.
Follow your healthcare provider's instructions regarding dosage and schedule. Do not exceed the prescribed dose or frequency of use without consulting your provider.
Amitriptyline is used to manage depression, anxiety, and chronic pain. The effects can be noticeable within a few weeks, but it may take up to four to six weeks for the full therapeutic effect to occur.
Continue using amitriptyline as prescribed, even if you start feeling better. Regular use according to your prescription is crucial for the management of your condition.
While amitriptyline is primarily used for treating depression. It may be prescribed off-label to treat anxiety and chronic pain, as well as migraines or insomnia (difficulty falling or staying asleep).
Discuss any alternative uses of amitriptyline with your healthcare provider.
Amitriptyline is available in the following dosage forms:
Amitriptyline is a prescription medication. You must have a valid prescription from a licensed healthcare provider to obtain it.
The use of amitriptyline can lead to various side effects in some individuals.
Common mild side effects of amitriptyline use include:
More severe side effects include:
If you experience any severe or concerning side effects while taking amitriptyline, contact your healthcare provider right away.
Inform your healthcare provider about any existing medical conditions, allergies, or other medications you are taking before starting treatment with quetiapine. This includes prescription drugs, over-the-counter medications, and dietary supplements, as they may interact with quetiapine.
Tell your provider if you are taking these medications or supplements:
You should also mention medical conditions such as:
If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of using amitriptyline with your healthcare provider.
Take amitriptyline exactly as prescribed by your healthcare provider. Do not exceed the recommended dose or duration of treatment.
Your provider may direct you to avoid alcohol while taking amitriptyline, as it can increase the risk of side effects.
Amitriptyline can cause drowsiness. Do not drive or operate machinery until you know how this medication affects you.
Complete the full course of treatment, even if you feel better, to ensure the medication's effectiveness in managing your symptoms.
In case of an amitriptyline overdose, seek medical attention immediately. Symptoms of overdose may include severe drowsiness, confusion, hallucinations, rapid heartbeat, seizures, or fainting. If you suspect an overdose, contact the poison control helpline at 1-800-222-1222 or call emergency services.
Amitriptyline is available in the following forms:
The typical starting dose of amitriptyline varies depending on the condition being treated, the severity of symptoms, and individual patient factors. It is crucial to follow your healthcare provider's instructions regarding dosage and administration.
For depression:
The dosage may be adjusted based on the response and tolerance to the medication. Your healthcare provider will determine the most appropriate dose based on your medical history and your response to the medication.
Amitriptyline should be taken as prescribed by your healthcare provider. Do not exceed the recommended dose or duration of treatment without consulting your provider.
If you have any questions about your dosage or need adjustments, contact your healthcare provider for guidance. If you want to talk to a provider right away, consider scheduling an online doctor appointment through a telehealth platform like Sesame.
If you miss a dose of amitriptyline, take it as soon as you remember unless it is close to the time for your next scheduled dose. In that case, skip the missed dose and continue your regular dosing schedule. Do not double the dose to make up for a missed one.
Take amitriptyline around the same time every day to maintain a consistent amount of medication in your body.
Continue taking amitriptyline as prescribed by your healthcare provider, even if you start feeling better. It's important to keep taking the medication as directed to manage your condition effectively.
Do not suddenly stop taking amitriptyline; this can cause withdrawal symptoms and a return of your symptoms.
If you have any concerns or questions about your medication, discuss them with your healthcare provider for medical advice and recommendations.
Store amitriptyline according to the instructions provided by your healthcare provider or pharmacist. Keep it at room temperature, away from light and moisture. Ensure the container is tightly closed and out of reach of children.
Do not use expired medication or medications that appear damaged or discolored. If you have any questions about storage, consult your healthcare provider or pharmacist for guidance.