Medically reviewed by Jessica Swirble, PharmD
Last updated on 6/18/2024
Drug Information | Side Effects | Use & Dosage | Request a Prescription
Amitriptyline is a prescription medication used to treat major depressive disorder (depression). It is classified as a tricyclic antidepressant medication, which increases serotonin levels in the brain.
Amitriptyline is prescribed to treat major depressive disorder (depression).
Amitriptyline is often prescribed in conjunction with other forms of medication to treat anxiety or depression related to anxiety. It is also commonly prescribed along with other forms of therapy, like psychotherapy (‘talk therapy’).
Amitriptyline belongs to a class of medicines known as tricyclic antidepressants.
Tricyclic antidepressants work by increasing the amount of serotonin in your brain. Your brain naturally produces two neurotransmitters called serotonin and norepinephrine, which can help you stay focused, emotionally stable, happier, and calmer. In patients with major depressive disorder, it is thought that serotonin levels are low, which leads to depression symptoms.
Tricyclic antidepressants block the absorption of serotonin and norepinephrine, which leads to a build-up of these neurotransmitters. The increased concentrations of norepinephrine and serotonin help reduce depression symptoms.
Amitriptyline is available as an oral tablet.
Follow your healthcare provider's instructions regarding dosage and schedule. Do not exceed the prescribed dose or frequency of use without consulting your provider.
Amitriptyline is used to manage depression, anxiety, and chronic pain. The effects can be noticeable within a few weeks, but it may take up to four to six weeks for the full therapeutic effect to occur.
Continue using amitriptyline as prescribed, even if you start feeling better. Regular use according to your prescription is crucial for the management of your condition.
While amitriptyline is primarily used for treating depression. It may be prescribed off-label to treat anxiety and chronic pain, as well as migraines or insomnia (difficulty falling or staying asleep).
Discuss any alternative uses of amitriptyline with your healthcare provider.
Amitriptyline is available in the following dosage forms:
Amitriptyline is a prescription medication. You must have a valid prescription from a licensed healthcare provider to obtain it.