Get a amitriptyline (generic Endep) prescriptions online for preventative migraines or depression.

Get a same-day amitriptyline (generic Endep) online prescription and pick up medication at your local pharmacy today. Preventing migraines or managing depression has never been this easy.

Local same-day pharmacy pick up
Prescription available at provider's discretion
Discounts on thousands of generic drugs
Thumb Up Icon95% patient satisfaction
Money Icon$25,000,000+ saved by patients
4.3 onTrustpilot logo
Trophy IconNamed Best Overall Telehealth byHealthline logo
Quote IconAs someone without insurance, Sesame was really great. – Dominic
Not sure? Keep in touch to learn more about Sesame.
Email address
Product Overview

Amitriptyline (generic Endep)

  • What is amitriptyline?
    Amitriptyline (generic Endep) is a prescription drug used to treat symptoms of depression or to help with pain. It increases the amounts of the substances in your brain that regulate your mood.

    Talk to your doctor about any medication you are currently taking before starting treatment with amitriptyline. Be sure to tell your doctor if you have a history of glaucoma, arrhythmia, bipolar disorder, epilepsy, or schizophrenia.

  • What are common side effects of amitriptyline?
    While adverse reactions to amitriptyline are rare, some patients who take the drug may experience mild side effects including constipation, drowsiness, dry mouth, urinary retention problems, blurred vision, weight gain, and changing blood sugar levels.

    Rare, more serious adverse events have been known to occur, such as slow or difficult speech, dizziness or faintness, weakness or numbness of an arm or a leg, chest pain, irregular heartbeat, severe skin rash or hives, swelling of the face and tongue, yellowing of the skin or eyes, muscle spasms, uncontrollable shaking of a part of the body, fainting, unusual bleeding or bruising, seizures, or hallucination. If you are experiencing any of these side effects, call your doctor right away or head to the emergency room.

    This is not a complete list of side effects. To learn more about adverse effects you may experience while taking amitriptyline, please visit the National Institutes of Health’s DailyMed webpage.

Patients Love Sesame

Medically Reviewed By Dr. Allison Edwards, MD

Frequently asked questions about amitriptyline

Amitriptyline hydrochloride (generic for brand names Elavil & Endep) is a prescription medication used to treat symptoms of depression. It may also produce sedative effects. Amitriptyline balances neurotransmitters, chemicals naturally produced in the brain, to stabilize your mood and alleviate some symptoms of depressive disorder. Unlike some antidepressant medications that focus on releasing serotonin, amitriptyline does not work to stimulate the central nervous system.

The Food and Drug Administration (FDA) has approved the prescription of amitriptyline to relieve symptoms of depression and treat major depressive disorder (MDD). Amitriptyline is more effective in treating MDD than other forms of depression.

While doctors do not fully understand how amitriptyline works, it has been shown to increase levels of neurotransmitters, such as serotonin and norepinephrine, in the brain. An increase of these chemicals has been shown to improve mood, sleep, alleviate symptoms of pain, and calm anxiety. Amitriptyline is approved by the FDA to relieve symptoms of depression and major depressive disorder. Amitriptyline will not cure depression, or make symptoms completely disappear, but it can help maintain mental health and aid with sleep, as it can cause drowsiness.

In addition to its use as an antidepressant drug, amitriptyline has been used by health care providers to treat symptoms of neuralgia and neuropathic pain (types of nerve pain). Though it has been used to treat instances of nerve pain, this is not amitriptyline's primary usage. Talk to your doctor about treatment options before using amitriptyline as a nerve pain therapeutic.

Amitriptyline has been approved by the FDA to relieve symptoms of depression and is commonly prescribed to patients because its mental health benefits outweigh its potential adverse side effects. Common side effects of amitriptyline include constipation, drowsiness, dry mouth, urinary retention problems, blurred vision, weight gain, and changing blood sugar levels. Talk to your doctor about any medication you are currently taking before starting treatment with amitriptyline. Amitriptyline is not recommended for patients currently taking an SSRI (e.g.: paroxetine, fluoxetine), antihistamine (e.g.: cimetidine), or anticholinergic (e.g.: quinidine) medication. In addition, tell your doctor if you are taking an herbal remedy for depression (like St. John's Wort), as drug interactions between these chemicals can cause adverse effects.

Be sure to tell your doctor if you have a health history of glaucoma, arrhythmia, bipolar disorder, epilepsy, or schizophrenia, as symptoms of these conditions may be heightened by amitriptyline therapy.

Finally, tell your doctor if you are currently pregnant or breastfeeding. Amitriptyline can be excreted into breast milk and may produce adverse effects in nursing children.

This is not a complete list of side effects associated with amitriptyline. For more information on adverse effects you may experience while taking amitriptyline, please visit the National Institutes of Health’s DailyMed webpage.

It may take a few weeks before you feel the effects of amitriptyline start to work. Do not stop taking amitriptyline without consulting your doctor. Even if you don't feel its effects, or start to feel better, it is important that you maintain consistency with your dosage. If you suddenly stop taking amitriptyline, you may experience withdrawal symptoms. Because of this, doctors will usually start to decrease dosing as patients begin to feel better. If you feel that your symptoms of depression are worsening, talk to your doctor right away.

Do not take a double dose after a missed dose of amitriptyline. Either take your missed dose when you remember or wait until your next dose. An overdose of amitriptyline can lead to toxicity in the body.

Doctors will commonly prescribe a low 75 mg per day dosage of amitriptyline for adults starting treatment. Amitriptyline may be taken anywhere from 1-4 times daily and should be taken at the same times every day. Some doctors recommend ingesting the daily dosage in the late afternoon or evening, as amitriptyline commonly causes drowsiness.

If necessary, dosage for adults may increase up to 150 mg per day. Young adults and adolescent patients will usually receive a prescription at a lower dosage, starting around 30 mg per day. It is common for younger patients to take 10 mg doses 3 times a day. A larger 20 mg dosage may be prescribed to be taken before bed.

Do not exceed your doctor's ordered dosage, or double a dose if you have a missed dose. Follow your doctor's orders and take only the prescribed amount of amitriptyline on the schedule laid out by your doctor.

Amitriptyline is currently only available via prescription. This means the use of this drug must be authorized by a licensed health care provider.

Providers on Sesame can write a prescription – or refill an existing one – during a virtual or in-person visit. Depending on the medication, you can arrange for same-day pickup at a pharmacy near you. Book an online consultation with a real, licensed provider on Sesame today to determine whether or not amitriptyline is right for you.

Note that all prescriptions are at the discretion of your health care provider. Providers on Sesame cannot prescribe controlled substances.

Yes! Talk to a provider on Sesame and get your online doctor prescription or refill ordered right away for fast and convenient pickup from a pharmacy of your choice.

Note that all prescriptions are at the discretion of your clinician.

  1. HomeChevron Right
  2. MedicationChevron Right
  3. Amitriptyline