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Generic Endep®

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Product Overview

Amitriptyline (generic Endep)

  • What is amitriptyline?
    Amitriptyline (generic Endep) is a prescription drug used to treat symptoms of depression or to help with pain. It increases the amounts of the substances in your brain that regulate your mood.

    Talk to your doctor about any medication you are currently taking before starting treatment with amitriptyline. Be sure to tell your doctor if you have a history of glaucoma, arrhythmia, bipolar disorder, epilepsy, or schizophrenia.

  • What are common side effects of amitriptyline?
    While adverse reactions to amitriptyline are rare, some patients who take the drug may experience mild side effects including constipation, drowsiness, dry mouth, urinary retention problems, blurred vision, weight gain, and changing blood sugar levels.

    Rare, more serious adverse events have been known to occur, such as slow or difficult speech, dizziness or faintness, weakness or numbness of an arm or a leg, chest pain, irregular heartbeat, severe skin rash or hives, swelling of the face and tongue, yellowing of the skin or eyes, muscle spasms, uncontrollable shaking of a part of the body, fainting, unusual bleeding or bruising, seizures, or hallucination. If you are experiencing any of these side effects, call your doctor right away or head to the emergency room.

    This is not a complete list of side effects. To learn more about adverse effects you may experience while taking amitriptyline, please visit the National Institutes of Health’s DailyMed webpage.

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Have more questions?

Frequently asked questions about amitriptyline

What is amitriptyline?

Amitriptyline hydrochloride (generic for brand names Elavil & Endep) is a prescription medication used to treat symptoms of depression. It may also produce sedative effects. Amitriptyline balances neurotransmitters, chemicals naturally produced in the brain, to stabilize your mood and alleviate some symptoms of depressive disorder. Unlike some antidepressant medications that focus on releasing serotonin, amitriptyline does not work to stimulate the central nervous system.

What is amitriptyline used to treat?

The Food and Drug Administration (FDA) has approved the prescription of amitriptyline to relieve symptoms of depression and treat major depressive disorder (MDD). Amitriptyline is more effective in treating MDD than other forms of depression.

How does amitriptyline work?

While doctors do not fully understand how amitriptyline works, it has been shown to increase levels of neurotransmitters, such as serotonin and norepinephrine, in the brain. An increase of these chemicals has been shown to improve mood, sleep, alleviate symptoms of pain, and calm anxiety. Amitriptyline is approved by the FDA to relieve symptoms of depression and major depressive disorder. Amitriptyline will not cure depression, or make symptoms completely disappear, but it can help maintain mental health and aid with sleep, as it can cause drowsiness.

In addition to its use as an antidepressant drug, amitriptyline has been used by health care providers to treat symptoms of neuralgia and neuropathic pain (types of nerve pain). Though it has been used to treat instances of nerve pain, this is not amitriptyline's primary usage. Talk to your doctor about treatment options before using amitriptyline as a nerve pain therapeutic.

What are the most common side effects of amitriptyline?

Amitriptyline has been approved by the FDA to relieve symptoms of depression and is commonly prescribed to patients because its mental health benefits outweigh its potential adverse side effects. Common side effects of amitriptyline include constipation, drowsiness, dry mouth, urinary retention problems, blurred vision, weight gain, and changing blood sugar levels. Talk to your doctor about any medication you are currently taking before starting treatment with amitriptyline. Amitriptyline is not recommended for patients currently taking an SSRI (e.g.: paroxetine, fluoxetine), antihistamine (e.g.: cimetidine), or anticholinergic (e.g.: quinidine) medication. In addition, tell your doctor if you are taking an herbal remedy for depression (like St. John's Wort), as drug interactions between these chemicals can cause adverse effects.

Be sure to tell your doctor if you have a health history of glaucoma, arrhythmia, bipolar disorder, epilepsy, or schizophrenia, as symptoms of these conditions may be heightened by amitriptyline therapy.

Finally, tell your doctor if you are currently pregnant or breastfeeding. Amitriptyline can be excreted into breast milk and may produce adverse effects in nursing children.

This is not a complete list of side effects associated with amitriptyline. For more information on adverse effects you may experience while taking amitriptyline, please visit the National Institutes of Health’s DailyMed webpage.

How long does it take for amitriptyline to work?

It may take a few weeks before you feel the effects of amitriptyline start to work. Do not stop taking amitriptyline without consulting your doctor. Even if you don't feel its effects, or start to feel better, it is important that you maintain consistency with your dosage. If you suddenly stop taking amitriptyline, you may experience withdrawal symptoms. Because of this, doctors will usually start to decrease dosing as patients begin to feel better. If you feel that your symptoms of depression are worsening, talk to your doctor right away.

Do not take a double dose after a missed dose of amitriptyline. Either take your missed dose when you remember or wait until your next dose. An overdose of amitriptyline can lead to toxicity in the body.

What is the typical starting dose of amitriptyline?

Doctors will commonly prescribe a low 75 mg per day dosage of amitriptyline for adults starting treatment. Amitriptyline may be taken anywhere from 1-4 times daily and should be taken at the same times every day. Some doctors recommend ingesting the daily dosage in the late afternoon or evening, as amitriptyline commonly causes drowsiness.

If necessary, dosage for adults may increase up to 150 mg per day. Young adults and adolescent patients will usually receive a prescription at a lower dosage, starting around 30 mg per day. It is common for younger patients to take 10 mg doses 3 times a day. A larger 20 mg dosage may be prescribed to be taken before bed.

Do not exceed your doctor's ordered dosage, or double a dose if you have a missed dose. Follow your doctor's orders and take only the prescribed amount of amitriptyline on the schedule laid out by your doctor.

Can I get amitriptyline online?

Yep! Now with Sesame Rx, you can get prescription medication mailed right to your front door starting at just $5/ month- without insurance. Doctors on Sesame can write a new prescription or refill an existing one during your in-person or video visit. After that, you can schedule a prescription medication delivery to your home. Don't stress about health care, use Sesame Rx to get quality care and convenient prescription deliveries all at clear and affordable prices.