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Product Overview

Divalproex DR (generic Depakote DR)

  • What is Divalproex DR?
    Divalproex delayed-release (generic Depakote ER) is a prescription medicine used to treat a range of conditions, including certain types of seizures, manic phases in people with bipolar disorder, and migraine headache prevention.

    Looking for a safe, effective way to manage symptoms caused by these conditions? Talk to your doctor about whether divalproex may be right for you.

  • What are the most common side effects of divalproex DR?
    While adverse reactions to divalproex are uncommon, some patients who take the drug may experience mild side effects, including stomach pain, nausea, diarrhea, dry or sore mouth, swollen gums, shakes in parts of your body, unusual eye movements, tiredness, headache, weight gain, thinning hair, and irregular menstrual periods.

    Get immediate medical attention if you experience any unusual bruises or bleeding; severe or persistent nausea, vomiting, or stomach pain; suicidal or harmful thoughts; yellowing of your skin or eyes; or any signs of an allergic reaction (such as swelling of the face, mouth or tongue; rash; hives; itching; or difficulty breathing or swallowing).

    This is not a complete list of side effects. If you are concerned about additional side effects, please contact your provider directly.

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Medically Reviewed by Dr. Allison Edwards, MD

Frequently asked questions about divalproex DR

Divalproex delayed-release is a prescription medicine used to treat a range of conditions, including certain types of seizures, manic phases in people with bipolar disorder, and migraine headaches. It belongs to a class of medications called anticonvulsants and works by restoring the balance of certain natural substances (known as neurotransmitters) in the brain.

The delayed-release capsules release the medication once it has reached the intestine to prevent damage to the stomach.

Divalproex is used by itself or with other medications to treat certain types of seizures. It may also be used for the treatment of mania (episodes of frenzied, abnormally excited mood) associated with bipolar disorder and to help prevent migraine headaches. While it is effective at preventing migraines, it does not relieve headaches that have already begun.

Divalproex prevents seizures by reducing electrical activity in your brain.

Researchers do not entirely understand how this medicine works for treating bipolar disorder or migraines, but it is thought to help balance certain chemicals in your brain that affect how the nerves transmit signals. Divalproex is safe and effective in treating these conditions.

Like all medications, divalproex can cause side effects. However, not everyone gets them and the effects are usually mild and go away as your body gets used to the medication. The most common side effects include stomach pain, nausea, diarrhea, dry or sore mouth, swollen gums, shakes in parts of your body, unusual eye movements, tiredness, headache, weight gain, thinning hair, and irregular menstrual periods. Talk to your doctor if any of these are severe or do not go away.

Get immediate medical attention if you experience any unusual bruises or bleeding; severe or persistent nausea, vomiting, or stomach pain; suicidal or harmful thoughts; yellowing of your skin or eyes; or any signs of allergic reaction (such as swelling of the face, mouth or tongue; rash; hives; itching; or difficulty breathing or swallowing).

Talk to your doctor about your medical history - particularly if you have ever had episodes of confusion or loss of ability to think and understand, difficulty coordinating your movements, HIV, cytomegalovirus (CMV), or have ever been in a coma. Inform your doctor of all known allergies and of all medications, supplements, and herbal products that you take. Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding.

This is not a complete list of side effects or precautions. For more information please visit the National Institutes of Health’s DailyMed webpage for divalproex DR.

Divalproex tablets reach peak levels about 4 hours after taking them. Because the delayed-release tablets have a coating that causes them to be digested in the intestines instead of the stomach, it may take slightly longer to reach a peak. If you’re taking divalproex to prevent seizures or manic episodes, it may take several weeks of regular dosing before you experience its full effect.

The starting dosage is based on the medical condition you’re treating as well as your age, weight, and response to treatment. Your doctor may start you on a low dose and gradually increase it over a few days or weeks. Follow the instructions on the packaging label carefully. Use Divalproex only as directed.

Divalproex is effective at controlling conditions but will not cure them. You should keep using this medication even if you feel well. Do not stop taking it without consulting your doctor.

Divalproex DR is currently only available via prescription. This means the use of this drug must be authorized by a licensed health care provider.

Providers on Sesame can write a prescription – or refill an existing one – during a virtual or in-person visit. Depending on the medication, you can arrange for same-day pickup at a pharmacy near you. Book an online consultation with a real, licensed provider on Sesame today to determine whether or not divalproex DR is right for you.

Note that all prescriptions are at the discretion of your health care provider. Providers on Sesame cannot prescribe controlled substances.

Yes! Talk to a provider on Sesame and get your online doctor prescription or refill ordered right away for fast and convenient pickup from a pharmacy of your choice.

Note that all prescriptions are at the discretion of your clinician.

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