Get a esomeprazole prescription online for GI conditions

Get convenient and affordable esomeprazole prescriptions available for same-day pickup at your local pharmacy. Talk to a health care provider on Sesame to start treatment right away.

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Product Overview

Esomeprazole (generic for Nexium)

  • What is esomeprazole?
    Esomeprazole is a medication that is prescribed to treat conditions caused by too much acid in the stomach. Esomeprazole is also available over the counter as a treatment for frequent heartburn in adults.

    Talk to your health care provider about whether or not esomeprazole is right for you.

  • What are the common side effects of esomeprazole?
    Esomeprazole has been shown to cause some side effects. Talk to your health care provider if these adverse reactions do not go away within a few days.


Common side effects reported from esomeprazole use include:

  • Constipation
  • Nausea
  • Headache
  • Constipation
  • Dizziness

This is not a complete list of all possible side effects caused by esomeprazole.

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Medically Reviewed By Dr. Allison Edwards, MD

Frequently asked questions about esomeprazole

Esomeprazole is a medication that is prescribed to treat conditions caused by too much acid in the stomach. This includes gastroesophageal reflux disease (GERD), duodenal and gastric ulcers, and erosive esophagitis (damage to the esophagus caused by stomach acid), among other illnesses. In addition, esomeprazole may be prescribed to patients taking nonsteroidal anti-inflammatory drugs (NSAIDs) as a preventative measure against stomach ulcers and stomach irritation that can be caused by NSAID use.

Esomeprazole is also available over the counter as a treatment for frequent heartburn in adults.

Esomeprazole is available in two strengths. Nonprescription (over-the-counter) esomeprazole is widely available as a treatment for frequent heartburn in adults. Heartburn is characterized by a burning pain in the chest that often occurs at night or after eating. Experiencing these symptoms twice a week or more is considered frequent heartburn.

Prescription-strength esomeprazole is used for the treatment of conditions caused by too much stomach acid in the body. This includes gastroesophageal reflux disease (GERD), duodenal and gastric ulcers, and erosive esophagitis, among others.

GERD, or gastroesophageal reflux disease, is a digestive disorder that primarily affects the lower esophageal sphincter (LES), the ring of muscle between the esophagus and stomach. This muscle opens when food enters your stomach and closes to keep it there. Stomach acid flowing the wrong way through this muscle causes a burning sensation in your chest (heartburn) accompanied by other symptoms such as difficulty swallowing, coughing and regurgitation of food or sour liquid. GERD can cause additional complications such as narrowing of the esophagus, ulcers in the lining of the esophagus, inflammation and infection (if contents from your stomach make their way into your lungs).

Duodenal and gastric ulcers are small sores that develop in the stomach or intestines. The most common cause of these sores is a bacterial infection. These forms of ulcers are not caused by stress, spicy foods, or stress. Duodenal and gastric ulcers can cause symptoms such as stomach pain, bloating, heartburn, and nausea.

Erosive esophagitis occurs when the tissue lining the esophagus is damaged. This is usually caused by acid reflux. Erosive esophagitis is a painful condition that can make it hard to swallow. When left untreated, this damage can cause a narrowing of the esophagus and frequent chest pain.

Esomeprazole belongs to a classification of medication known as proton pump inhibitors. These drugs work by inhibiting the production of acid made by glands in the stomach lining. By reducing levels of stomach acid in your gastroesophageal system, esomeprazole helps prevent and treat symptoms of GERD, ulcers, and erosive esophagitis.

The use of esomeprazole may cause side effects. Talk to your health care provider if these adverse reactions do not go away within a few days or become severe.

Common side effects reported when taking esomeprazole include:

  • Constipation
  • Headache
  • Dizziness
  • Nausea
  • Diarrhea

This is not a complete list of adverse effects – though these are the most common. Seek medical attention right away if you experience symptoms such as swelling, difficulty breathing, rash, changes in heartbeat, or severe diarrhea while taking esomeprazole.

As with all prescription medication, be sure to inform the prescribing doctor about any medical conditions you have been previously diagnosed with and any medication/ supplements you are currently taking before taking esomeprazole. Esomeprazole can interact with other forms of medication and substances, causing potentially serious side effects. In addition, let your doctor know if you are planning to become pregnant, are pregnant, or are currently breastfeeding before starting treatment with this medication.

Esomeprazole is commonly supplied as an oral capsule or liquid suspension. For GERD, erosive esophagitis and ulcers, 20-40 mg of prescription-strength esomeprazole should be taken once a day. The duration of your treatment (how long you take the medication) varies depending on the condition being treated.

For GERD and erosive esophagitis, esomeprazole should be taken once a day for 4-8 weeks. Your doctor may adjust your dosage as needed, and the course of treatment can last up to 6 months.

As a preventative measure against stomach ulcers caused by NSAID use, 20-40 mg of esomeprazole should be taken once a day for up to 6 months. Your doctor may adjust your dosage as needed.

As a treatment for heartburn, 20 mg of over-the-counter esomeprazole should be taken once a day for 14 days. Talk to a health care provider if symptoms do not subside after 2 weeks.

Do not discontinue or increase your dosage of esomeprazole without first consulting your doctor. Take the medication exactly as prescribed, and inform your doctor if you begin to experience any side effects while taking the medication. Importantly, esomeprazole should be taken for the shortest duration possible to prevent long-term poor outcomes and side effects.

As a treatment for frequent heartburn, certain dosages of esomeprazole are available over the counter. Talk to a health care provider before starting treatment with over-the-counter esomeprazole to discuss the dosage that’s best for you.

Good news! If deemed clinically appropriate, providers on Sesame can write a prescription for esomeprazole to be picked up near you – often within the same day! Simply talk to a clinician and get your online doctor prescription or refill ordered right away for fast and convenient pickup from a pharmacy of your choice.

Note that all prescriptions are at the discretion of your healthcare provider.

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